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Breast Cancer Treatment (PDQ®)

Health Professional Version
Last Modified: 07/11/2014

Cellular Classification of Breast Cancer

The following is a list of breast cancer histologic classifications.[1] Infiltrating or invasive ductal cancer is the most common breast cancer histologic type and comprises 70% to 80% of all cases.

  • Carcinoma, NOS (not otherwise specified).

  • Ductal.
    • Intraductal (in situ).
    • Invasive with predominant intraductal component.
    • Invasive, NOS.
    • Comedo.
    • Inflammatory.
    • Medullary with lymphocytic infiltrate.
    • Mucinous (colloid).
    • Papillary.
    • Scirrhous.
    • Tubular.
    • Other.

  • Lobular.
    • In situ.
    • Invasive with predominant in situ component.
    • Invasive.[2]

  • Nipple.
    • Paget disease, NOS.
    • Paget disease with intraductal carcinoma.
    • Paget disease with invasive ductal carcinoma.

  • Other.
    • Undifferentiated carcinoma.

The following are tumor subtypes that occur in the breast but are not considered to be typical breast cancers:

  • Phyllodes tumor.[3,4]
  • Angiosarcoma.
  • Primary lymphoma.
References
  1. Breast. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 347-76. 

  2. Yeatman TJ, Cantor AB, Smith TJ, et al.: Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg 222 (4): 549-59; discussion 559-61, 1995.  [PUBMED Abstract]

  3. Chaney AW, Pollack A, McNeese MD, et al.: Primary treatment of cystosarcoma phyllodes of the breast. Cancer 89 (7): 1502-11, 2000.  [PUBMED Abstract]

  4. Carter BA, Page DL: Phyllodes tumor of the breast: local recurrence versus metastatic capacity. Hum Pathol 35 (9): 1051-2, 2004.  [PUBMED Abstract]