Changes to This Summary (12/03/2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that a prospective trial of the combination of tamoxifen and sulindac reported few side effects, although asymptomatic ovarian cysts were common in girls. This combination showed relatively little activity, as measured by rates of response and progression-free survival (cited Skapek et al. as reference 29 and level of evidence 2Diii).
Revised text to state that chemotherapy and interferon have had some benefit in isolated cases of hemangioendothelioma associated with Kasabach-Merritt syndrome.
Added Fernandez-Pineda et al. as reference 165.
Added text to state that angiosarcomas have also been described in previously benign hemangiomas and hemangioendotheliomas. Also revised text about a study of five girls with liver angiosarcoma, their presentation and progression, and author recommendations for liver ultrasound surveillance and liver transplantation.
Added text to state that data on liver transplantation for localized angiosarcoma are limited.
Added text to state that chemotherapy may be effective for the treatment of angiosarcoma.
This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.