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Childhood Hematopoietic Cell Transplantation (PDQ®)

  • Posted: 02/15/2012
  • Updated: 06/20/2014

Table 1. Level of Human Leukocyte Antigen (HLA) Typing Currently Used for Different Hematopoietic Stem Cell Sourcesa,b

 Class I Antigens  Class II Antigens 
Stem Cell Source HLA A HLA B HLA C HLA DRB1 HLA DQB1 HLA DPB1
Matched Sibling BM/PBSCs AntigenAntigenOptionalAllele
Matched Sibling/Other Related Donorc BM/PBSCs AlleleAlleleAlleleAlleleOptionalOptional
Unrelated Donor BM/PBSCs AlleleAlleleAlleleAlleleOptionalOptional
Unrelated Cord Blood Antigen (Allele Optional)Antigen (Allele Optional)Allele OptionalAlleleOptionalOptional

BM = bone marrow; PBSC = peripheral blood stem cells.
aHLA antigen: A serologically defined, low-resolution method of defining an HLA protein. Differs from allele-level typing half of the time. Designated by the first two numbers (i.e., HLA B 35:01—antigen is HLA B 35).
bHLA allele: A higher resolution method of defining unique HLA proteins by typing their gene through sequencing or other DNA-based methods that detect unique differences. Designated by at least four numbers (i.e., HLA B 35:01).
cParent, cousin, etc., with a phenotypic match or near-complete HLA match.