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Childhood Hematopoietic Cell Transplantation (PDQ®)

  • Posted: 02/15/2012
  • Updated: 04/08/2014

Table 8. Chronic Graft-versus-Host Disease (GVHD) Symptoms in the Mouth and GI Tracta

Organ or Site Diagnosticb Distinctivec Other Featuresd Common (Seen with Both Acute and Chronic GVHD)  
MouthLichen-type featuresXerostomiaGingivitis
Hyperkeratotic plaquesMucoceleMucositis
Restriction of mouth opening from sclerosisPseudomembraneseErythema
Mucosal atrophyPain
Ulcerse
GI TractEsophageal webExocrine pancreatic insufficiencyAnorexia
Strictures or stenosis in the upper to mid third of the esophaguseNausea
Vomiting
Diarrhea
Weight loss
Failure to thrive (infants and children)
Total bilirubin, alkaline phosphatase >2 × ULNe
ALT or AST >2 × ULNe

ALT = alanine aminotransferase; AST = aspartate aminotransferase; GI = gastrointestinal; ULN = upper limit of normal.
Refer to Table 7 footers for definitions of a through e.