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Childhood Rhabdomyosarcoma Treatment (PDQ®)
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Table 2: IRS Group Surgicopathologic Grouping System

Group  Definition 
I  [Note: Approximately 13% of all patients are in this Group.] A localized tumor that is completely removed with pathologically clear margins and no regional lymph node involvement.
II  [Note: Approximately 20% of all patients are in this Group.] A localized tumor that is grossly removed with: (A) microscopic disease at the margin, (B) involved, grossly removed regional lymph nodes, or (C) both A and B.
III  [Note: Approximately 48% of all patients are in this Group.] A localized tumor with gross residual disease after incomplete removal or biopsy only.
IV  [Note: Approximately 18% of all patients are in this Group.] Distant metastases are present at diagnosis.


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