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Childhood Rhabdomyosarcoma Treatment (PDQ®)

  • Updated: 11/26/2013

Table 3. Soft Tissue Sarcoma Committee of the Children's Oncology Group: Surgical-pathologic Group System

Group Incidence Definition 
IApproximately 13%Localized tumor, completely removed with microscopically clear margins and no regional lymph node involvement. Lymph node biopsy or sampling is encouraged if lymph nodes are clinically or radiographically suspicious.
IIApproximately 20%Localized tumor, completely removed with: (a) microscopic disease at the margin, (b) regional disease with involved, grossly removed regional lymph nodes without microresidual disease, or (c) regional disease with involved nodes, grossly removed but with microscopic residual and/or histologic involvement of the most distal node from the primary tumor.
IIIApproximately 48%Localized tumor, incompletely removed with gross, residual disease after: (a) biopsy only, or (b) gross major resection of the primary tumor (>50%).
IVApproximately 18%Distant metastases are present at diagnosis. This category includes: (a) radiographically identified evidence of tumor spread, and (b) positive tumor cells in cerebral spinal fluid, pleural, or peritoneal fluids, or implants in these regions.