Stage Information for Endometrial Cancer
The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) and the American Joint Committee on Cancer (AJCC) have designated staging to define endometrial cancer; the FIGO system is most commonly used.[1,2]
Carcinosarcomas should be staged as carcinoma. FIGO stages are further subdivided by the histologic grade of the tumor, for example, stage IC G2.
|aAdapted from FIGO Committee on Gynecologic Oncology.|
|bEither G1, G2, or G3 (G = grade).|
|cEndocervical glandular involvement only should be considered as stage I and no longer as stage II.|
|dPositive cytology has to be reported separately without changing the stage.|
|Ib||Tumor confined to the corpus uteri.|
|IAb||No or less than half myometrial invasion.|
|IBb||Invasion equal to or more than half of the myometrium.|
|IIb||Tumor invades cervical stroma but does not extend beyond the uterus.c|
|IIIb||Local and/or regional spread of the tumor.|
|IIIAb||Tumor invades the serosa of the corpus uteri and/or adnexae.d|
|IIIBb||Vaginal and/or parametrial involvement.d|
|IIICb||Metastases to pelvic and/or para-aortic lymph nodes.d|
|IIIC1b||Positive pelvic nodes.|
|IIIC2b||Positive para-aortic lymph nodes with or without positive pelvic lymph nodes.|
|IVb||Tumor invades bladder and/or bowel mucosa, and/or distant metastases.|
|IVAb||Tumor invasion of bladder and/or bowel mucosa.|
|IVBb||Distant metastases, including intra-abdominal metastases and/or inguinal lymph nodes.|
Even if it no longer influences staging, retrospective data based on the Surveillance, Epidemiology, and End Results Program suggest that positive peritoneal cytology is an independent risk factor in patients with early-stage endometrial cancer.
- Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105 (2): 103-4, 2009. [PUBMED Abstract]
- Corpus uteri. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 403-18.
- Garg G, Gao F, Wright JD, et al.: Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer. Gynecol Oncol 128 (1): 77-82, 2013. [PUBMED Abstract]