 |
|
|
Table 2: Comparison of Pediatric PEB and JEB Chemotherapy Dosing Schedules
|
Regimen
|
Bleomycin
|
Etoposide
|
Cisplatin
|
Carboplatin
|
References
|
| Pediatric PEB (every 21 days) |
15 units/m², day 1 |
100 mg/m², days 1–5 |
20 mg/m², days 1–5 |
|
[6,7] |
| Pediatric JEB (every 21–28 days) |
15 mg/m², day 1 |
120 mg/m², days 1–3 |
|
600 mg/m² or 6 mg/mL/min., day 2 |
[8] |
|
|
|
|
|
|
|
|
|
|
|
|
References
-
Rogers PC, Olson TA, Cullen JW, et al.: Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol 22 (17): 3563-9, 2004.
[PUBMED Abstract]
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Cushing B, Giller R, Cullen JW, et al.: Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol 22 (13): 2691-700, 2004.
[PUBMED Abstract]
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Mann JR, Raafat F, Robinson K, et al.: The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18 (22): 3809-18, 2000.
[PUBMED Abstract]
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