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Hairy Cell Leukemia Treatment (PDQ®)

  • Last Modified: 10/24/2014

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General Information About Hairy Cell Leukemia

Prognostic Factors
Diagnosis



Prognostic Factors

Hairy cell leukemia is an indolent, low-grade, B-cell lymphoma usually characterized by the following:

  • Circulating B-cells with cytoplasmic projections ("hairy" appearance).
  • Splenomegaly.
  • Absent lymphadenopathy.
  • Pancytopenia.
  • Monocytopenia.
Diagnosis

In addition to the B-cell antigens CD19, CD20, and CD22, the cells coexpress CD11c, CD25, and CD103. The BRAF-V600E mutation is a hairy cell leukemia–defining genetic lesion that can be used diagnostically.[1,2] The decision to treat is based on symptomatic cytopenias, massive splenomegaly, or the presence of other complications. About 10% of all patients will never require therapy.

References
  1. Tiacci E, Schiavoni G, Forconi F, et al.: Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation. Blood 119 (1): 192-5, 2012.  [PUBMED Abstract]

  2. Naik RR, Saven A: My treatment approach to hairy cell leukemia. Mayo Clin Proc 87 (1): 67-76, 2012.  [PUBMED Abstract]