Changes to This Summary (08/23/2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that hairy cell leukemia is an indolent, low-grade, B-cell lymphoma usually characterized by circulating B-cells with cytoplasmic projections, splenomegaly, absent lymphadenopathy, pancytopenia, and monocytopenia.
Added text to state that in addition to the B-cell antigens CD19, CD20, and CD22, the cells coexpress CD11c, CD25, and CD103. Also added that the BRAF-V600E mutation is a hairy cell leukemia–defining genetic lesion that can be used diagnostically (cited Tiacci et al. and Naik et al. as references 1 and 2, respectively).
This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.