Table 2. Cardiovascular Late Effects
| Predisposing Therapy | Potential Cardiovascular Effects | Health Screening |
| DOE = dyspnea on exertion; SOB = shortness of breath. | ||
| Anthracyclines (daunorubicin, doxorubicin, idarubicin, epirubicin); mitoxantrone | Cardiomyopathy; arrhythmias; subclinical left ventricular dysfunction | History: SOB, DOE, orthopnea, chest pain, palpitations |
| Cardiovascular exam | ||
| Echocardiogram or other modality to evaluate left ventricular systolic function | ||
| Electrocardiogram | ||
| Laboratory: lipid profile, consider troponin or brain natriuretic peptide (BNP) level | ||
| Radiation impacting the heart | Congestive heart failure; cardiomyopathy; pericarditis/pericardial fibrosis; valvular disease; atherosclerotic heart disease/myocardial infarction; arrhythmia | History: SOB, DOE, orthopnea, chest pain, palpitations |
| Cardiovascular exam: signs of heart failure, arrhythmia, valve dysfunction | ||
| Echocardiogram or other modality to evaluate left ventricular systolic function | ||
| Electrocardiogram | ||
| Laboratory: lipid profile | ||
| Radiation impacting vascular structures | Carotid or subclavian artery disease | History: transient/permanent neurological events |
| Blood pressure | ||
| Cardiovascular exam: peripheral pulses, presence of bruits | ||
| Neurological exam | ||
| Carotid ultrasound | ||
| Laboratory: lipid profile | ||
| Plant alkaloids (vinblastine, vincristine) | Vasospastic attacks (Raynaud’s phenomena); autonomic dysfunction (e.g., monotonous pulse) | History: vasospasms of hands, feet, nose, lips, cheeks, or earlobes related to stress or cold temperatures |
| Exam of affected area | ||
| Electrocardiogram | ||
| Platinum agents (cisplatin, carboplatin) | Dyslipidemia | Fasting lipid profile |
