In English | En español
Questions About Cancer? 1-800-4-CANCER

Late Effects of Treatment for Childhood Cancer (PDQ®)

  • Posted: 04/23/2004
  • Updated: 10/27/2014

Table 4. Oral/Dental Late Effects

Predisposing Therapy Oral/Dental Effects Health Screening/Interventions 
CT = computed tomography; GVHD = graft-versus-host disease; MRI = magnetic resonance imaging.
Any chemotherapy; radiation impacting oral cavityDental developmental abnormalities; tooth/root agenesis; microdontia; root thinning/shortening; enamel dysplasiaDental evaluation and cleaning every 6 months
Regular dental care including fluoride applications
Consultation with orthodontist experienced in management of irradiated childhood cancer survivors
Baseline panorex before dental procedures to evaluate root development
Radiation impacting oral cavityMalocclusion; temporomandibular joint dysfunctionDental evaluation and cleaning every 6 months
Regular dental care including fluoride applications
Consultation with orthodontist experienced in management of irradiated childhood cancer survivors
Baseline panorex before dental procedures to evaluate root development
Radiation impacting oral cavity; hematopoietic cell transplantation with history of chronic GVHDXerostomia/salivary gland dysfunction; periodontal disease; dental caries; oral cancer (squamous cell carcinoma)Dental evaluation and cleaning every 6 months
Supportive care with saliva substitutes, moistening agents, and sialogogues (pilocarpine)
Regular dental care including fluoride applications
Radiation impacting oral cavity (≥40 Gy)OsteoradionecrosisHistory: impaired or delayed healing after dental work
Exam: persistent jaw pain, swelling or trismus
Imaging studies (x-ray, CT scan and/or MRI) may assist in making diagnosis
Surgical biopsy may be needed to confirm diagnosis
Consider hyperbaric oxygen treatments