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Late Effects of Treatment for Childhood Cancer (PDQ®)

Health Professional Version

Changes to This Summary (12/17/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information About Late Effects of Treatment for Childhood Cancer

Added text about the increased risk of morbidity and mortality among aging survivors beyond the fourth decade of life in the Childhood Cancer Survivor Study (cited Armstrong et al. as reference 6).

Added Figure 1 about the cumulative incidence of chronic health conditions for severe, disabling, life-threatening, or fatal health conditions by primary childhood cancer diagnosis.

Revised text to state that an essential service of long-term follow-up programs is the organization of an individualized survivorship care plan that includes details about therapeutic interventions undertaken for childhood cancer and their potential health risks (chemotherapy type and cumulative dose, radiation treatment fields and dose, surgical procedures, blood product transfusions, and hematopoietic cell transplantation).

The remainder of this summary was extensively revised.

Late Effects of the Digestive System

This section was comprehensively reviewed.

Late Effects of the Immune System

This section was comprehensively reviewed.

Late Effects of the Musculoskeletal System

This section was comprehensively reviewed.

Late Effects of the Reproductive System

This section was comprehensively reviewed.

Late Effects of the Respiratory System

This section was comprehensively reviewed.

Late Effects of the Urinary System

This section was comprehensively reviewed.

This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  • Updated: December 17, 2014