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Late Effects of Treatment for Childhood Cancer (PDQ®)

Health Professional Version
Last Modified: 04/04/2014

Changes to This Summary (04/04/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Subsequent Neoplasms

Added Koike et al. as reference 42.

Late Effects of the Cardiovascular System

Added text about the significantly increased risks of major cardiac events observed in survivors treated with chest-directed radiation or anthracycline chemotherapy; this risk was enhanced by the presence of modifiable cardiovascular risk factors such as hypertension, diabetes mellitus, dyslipidemia, and obesity (cited Armstrong et al. as reference 73).

Late Effects of the Central Nervous System

Revised text to state that risk factors for the development of neurocognitive side effects are female gender, young age at the time of treatment, supratentorial tumor location, higher radiation dose, treatment with both cranial radiation and chemotherapy (systemic or intrathecal), and lower socioeconomic status (cited Butler et al. as reference 5).

Added Palmer et al. as reference 16 and Zeller et al. as reference 19.

Added text about adult survivors of extracranial solid tumors of childhood who experienced motor impairment in association with vincristine exposure and sensory impairment in association with cisplatin exposure (cited Ness et al. as reference 57).

Late Effects of the Immune System

The Spleen subsection was extensively revised.

This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.