The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Common Late Effects of Childhood Cancer by Body System ¹

Added text ² to state that studies suggest that dexrazoxane is safe and does not interfere with chemotherapeutic efficacy. There is a single-study experience suggesting that there could be an increase in malignancies when mulitple topoisomerase inhibitors are administered in close proximity; however, at this time, this should not preclude treatment with dexrazoxane (cited Tebbi and Cvetkovic as references 146 and 147, respectively).