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Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)

  • Updated: 06/24/2014

Table 1. Clinical Presentation of Plasma Cell Neoplasms

Plasma Cell Neoplasm M Protein Type Pathology Clinical Presentation 
MGUS = monoclonal gammopathy of undetermined significance.
MGUSIgG kappa or lambda; or IgA kappa or lambda<10% plasma cells in bone marrowAsymptomatic, with minimal evidence of disease (aside from the presence of an M protein) [2]
Isolated plasmacytoma of boneIgG kappa or lambda; or IgA kappa or gammaSolitary lesion of bone; <10% plasma cells in marrow of uninvolved siteAsymptomatic or symptomatic
Extramedullary plasmacytomaIgG kappa or lambda; or IgA kappa or gammaSolitary lesion of soft tissue; most commonly occurs in the nasopharynx, tonsils, or paranasal sinuses [3]Asymptomatic or symptomatic
Multiple myelomaIgG kappa or lambda; or IgA kappa or gammaOften, multiple lesions of boneSymptomatic


  1. Kyle RA, Rajkumar SV: Monoclonal gammopathy of undetermined significance and smouldering multiple myeloma: emphasis on risk factors for progression. Br J Haematol 139 (5): 730-43, 2007.  [PUBMED Abstract]

  2. Knowling MA, Harwood AR, Bergsagel DE: Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol 1 (4): 255-62, 1983.  [PUBMED Abstract]