Table 3. Risk Groups for Multiple Myeloma
| Risk Group | Cytogenetic Findings | Disease Characteristics |
| FISH = fluorescence in situ hybridization. | ||
| Standard risk | Has any of the following cytogenetic findings: (1) no adverse FISH or cytogenetics, (2) hyperdiploidy, (3) t(11;14) by FISH, or (4) t(6;14) by FISH. | These patients most often have (1) disease that expresses IgG kappa monoclonal gammopathies and (2) lytic bone lesions. |
| High risk | Has any of the following cytogenetic findings: (1) del 17p by FISH, (2) t(4;14) by FISH, (3) t(14;16) by FISH, (4) cytogenetic del 13, or (5) hypodiploidy. | These patients have (1) disease that expresses IgA lambda monoclonal gammopathies (often) and (2) skeletal-related complications (less often). |
