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Table 2. Definitions of TNM Stage I through Stage IVa

Stage  Tumor Grade Tumor Size 
IALow<8 cm
IBLow>8 cm
IIAHigh<8 cm
IIBHigh>8 cm
IIIAny tumor grade, skip metastasesb
IVAny tumor grade, any tumor size, distant metastases

aReprinted with permission from AJCC: Bone. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 281-90.
bSkip metastases: discontinuous tumors in the primary bone site.