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Ovarian Epithelial Cancer Treatment (PDQ®)

  • Updated: 06/24/2014

Table 2. Paclitaxel/Platinum Combinations Versus Comparator Arms in Trials

Trial Treatment Regimens No. of Patients % Early Crossover Progression-free Survival (mo) Overall Survival (mo) 
GOG-132 Paclitaxel (135 mg/m2, 24 h) and cisplatin (75 mg/m2)20122%14.226.6
Cisplatin (100 mg/m2)20040%16.430.2
Paclitaxel (200 mg/m2, 24 h)21323%11.2a26
MRC-ICON3[30]Paclitaxel (175 mg/m2, 3 h) and carboplatin AUC 647823%17.336.1
Carboplatin AUC 694325%16.135.4
Paclitaxel (175 mg/m2, 3 h) and carboplatin AUC 623223%1740
Cyclophosphamide (500 mg/m2) and doxorubicin (50 mg/m2) and cisplatin (50 mg/m2)42120%1740
GOG-111[18]Paclitaxel (135 mg/m2, 24 h) and cisplatin (75 mg/m2)184None1838
Cyclophosphamide (750 mg/m2) and cisplatin (75 mg/m2)202None13a24a
EORTC-55931[19]Paclitaxel (175 mg/m2, 3 h) and cisplatin (75 mg/m2)162None15.535.6
Cyclophosphamide (750 mg/m2) and cisplatin (75 mg/m2)1614%11.5a25.8a

AUC = area under the curve.
aStatistically inferior result (P < .001–< .05).

References

  1. du Bois A, Lück HJ, Meier W, et al.: A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 95 (17): 1320-9, 2003.  [PUBMED Abstract]

  2. Neijt JP, Engelholm SA, Tuxen MK, et al.: Exploratory phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer. J Clin Oncol 18 (17): 3084-92, 2000.  [PUBMED Abstract]

  3. The International Collaborative Ovarian Neoplasm Group: Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: the ICON3 randomised trial. Lancet 360 (9332): 505-15, 2002.  [PUBMED Abstract]