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Primary CNS Lymphoma Treatment (PDQ®)

Health Professional Version
Last Modified: 10/10/2014

Changes to This Summary (10/10/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Treatment Option Overview

Added text to state that a phase II feasibility study used chemotherapy induction with methotrexate, temozolomide, and rituximab plus consolidation with etoposide and high-dose cytarabine; with a median follow-up of 4.9 years, this phase II Cancer and Leukemia Group B (CALGB) trial of 44 patients reported a complete radiographic response in 66% of the patients, a 2-year progression-free survival of 57%, and an estimated overall survival of 65% at 4 years (cited Rubenstein et al. as reference 34 and level of evidence 3iiiDiv). Also added that a randomized, prospective trial by the CALGB will compare this nonstandard induction regimen versus the same induction chemotherapy with myeloablative peripheral stem cell transplantation.

This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.