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Cellular Classification
Current Clinical Trials
The tumor is composed mainly of undifferentiated anaplastic cells that arise
from the nuclear layers of the retina. Histology shows similarity to
neuroblastoma and medulloblastoma, including aggregation around blood vessels,
necrosis, calcification, and Flexner-Wintersteiner rosettes. Retinoblastomas
are characterized by marked cell proliferation as evidenced by high mitosis
counts and extremely high MIB-1 labeling indices.[1]
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with retinoblastoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
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Schwimer CJ, Prayson RA: Clinicopathologic study of retinoblastoma including MIB-1, p53, and CD99 immunohistochemistry. Ann Diagn Pathol 5 (3): 148-54, 2001.
[PUBMED Abstract]
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