Current Clinical Trials

Standard treatment options:

1. For resectable primary disease:
   • Radical surgical resection.[1,2]
2. For unresectable primary disease:
   • Surgical bypass of obstructing lesion.
   • Palliative radiation therapy.

Treatment options under clinical evaluation:

1. For unresectable primary disease:
   • Clinical trials evaluating methods to improve local control, such as the use of radiation therapy with radiosensitizers with or without systemic chemotherapy.



2. For unresectable metastatic disease:
   • Clinical trials evaluating the value of new anticancer drugs and biologicals (phase I and phase II studies).

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with small intestine adenocarcinoma ¹. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site ².

References

1. Rose DM, Hochwald SN, Klimstra DS, et al.: Primary duodenal adenocarcinoma: a ten-year experience with 79 patients. J Am Coll Surg 183 (2): 89-96, 1996.  [PUBMED Abstract]
   
   
2. North JH, Pack MS: Malignant tumors of the small intestine: a review of 144 cases. Am Surg 66 (1): 46-51, 2000.  [PUBMED Abstract]