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Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)

  • Updated: 06/27/2014

Table 3. Overview of Standard Treatment for Stage I Wilms Tumor

Stage Histology 4-Year RFS or EFS 4-Year OS Treatment (refer to Table 2 for chemotherapy regimen descriptions) 
Stage I [67,100,101]FH <24 mo/tumor weight <550g85%98%Surgery only (not standard treatment; should be done only in the context of a clinical trial)
FH >24 mo/tumor weight >550g94% RFS98%Nephrectomy + lymph node sampling followed by regimen EE-4A
FA68%a89%Nephrectomy + lymph node sampling followed by regimen EE-4A and XRT
DA68% EFS79% (n = 10)Nephrectomy + lymph node sampling followed by regimen EE-4A and XRT

DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy.
aFewer than five patients have survived 4 years; therefore, results should be interpreted with caution.

References

  1. Grundy PE, Breslow NE, Li S, et al.: Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol 23 (29): 7312-21, 2005.  [PUBMED Abstract]

  2. Dome JS, Cotton CA, Perlman EJ, et al.: Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study. J Clin Oncol 24 (15): 2352-8, 2006.  [PUBMED Abstract]

  3. Shamberger RC, Anderson JR, Breslow NE, et al.: Long-term outcomes for infants with very low risk Wilms tumor treated with surgery alone in National Wilms Tumor Study-5. Ann Surg 251 (3): 555-8, 2010.  [PUBMED Abstract]