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Leucemia linfoblástica aguda infantil: Tratamiento (PDQ®)

  • Actualización: 10 de abril de 2014

Cuadro 3. Resultado según el protocolo de tratamiento para adolescentes y adultos jóvenes con leucemia linfoblástica aguda

Sitio y grupo de estudio Pacientes adolescentes y adultos jóvenes (No.) Mediana de edad (años) Supervivencia (%) 
Estados Unidos [29]
CCG (pediátrico)1971667, SG 7 años
CALGB (adultos)1241946
Francia [35]
FRALLE 93 (pediátrico)771667 SSC
LALA 941001841
Italia [36]
AEIOP (pediátrico)1501580, SG 2 años
GIMEMA (adultos)951671
Países Bajos [37]
DCOG (pediátrico)471271 SSC
HOVON442038
Suecia [38]
NOPHO 92 (pediátrico)361674, SG 5 años
LLA en adultos991839
Reino Unido [32]
MRC LLA (pediátrico)6115–1771, SG 5 años
UKALL XII (adultos)6715–1756

LLA = Leucemia linfoblástica aguda; SSC = Supervivencia sin complicaciones; SG = Supervivencia general.
AEIOP = Associazione Italiana Ematologia Oncologia Pediatrica; CALGB = Cancer and Leukemia Group B; CCG = Children's Cancer Group; DCOG = Dutch Childhood Oncology Group; FRALLE = French Acute Lymphoblastic Leukaemia; GIMEMA = Gruppo Italiano Malattie e Matologiche dell' Adulto; HOVON = Dutch-Belgian Hemato-Oncology Cooperative Group; LALA = France-Belgium Group for Lymphoblastic Acute Leukemia in Adults; MRC = Medical Research Council (United Kingdom); NOPHO = Nordic Society for Pediatric Hematology and Oncology; UKALL = United Kingdom Acute Lymphoblastic Leukaemia.

Bibliografía

  1. Stock W, La M, Sanford B, et al.: What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies. Blood 112 (5): 1646-54, 2008.  [PUBMED Abstract]

  2. Ramanujachar R, Richards S, Hann I, et al.: Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials. Pediatr Blood Cancer 48 (3): 254-61, 2007.  [PUBMED Abstract]

  3. Boissel N, Auclerc MF, Lhéritier V, et al.: Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J Clin Oncol 21 (5): 774-80, 2003.  [PUBMED Abstract]

  4. Testi AM, Valsecchi MG, Conter V, et al.: Difference in outcome of adolescents with acute lymphoblastic leukemia (ALL) enrolled in pediatric (AIEOP) and adult (GIMEMA) protocols. [Abstract] Blood 104: A-1954, 2004. 

  5. de Bont JM, van der Holt B, Dekker AW, et al.: [Adolescents with acute lymphatic leukaemia achieve significantly better results when treated following Dutch paediatric oncology protocols than with adult protocols]. Ned Tijdschr Geneeskd 149 (8): 400-6, 2005.  [PUBMED Abstract]

  6. Hallböök H, Gustafsson G, Smedmyr B, et al.: Treatment outcome in young adults and children >10 years of age with acute lymphoblastic leukemia in Sweden: a comparison between a pediatric protocol and an adult protocol. Cancer 107 (7): 1551-61, 2006.  [PUBMED Abstract]