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About NSDB

Confocal laser scanning microscopy image showing kidney cancer cells labeled by phosphorylcholine-coated semiconducting polymer nanoparticles.

This confocal laser scanning microscopy image shows kidney cancer cells (cell nuclei in blue, cell skeleton in green) labeled by phosphorylcholine-coated semiconducting polymer nanoparticles (red). The phosphorylcholine coating allows very efficient and rapid endocytosis into the cell (about 30 minutes) while the semiconducting polymer allows durable and long-lasting fluorescence to measure multiple biological processes unique to cancer cell sub-types. Cells labeled with this nanoparticle can be imaged in vivo, with only a 35 percent decrease in fluorescence intensity after 12 days.

The Nanodelivery Systems and Devices Branch (NSDB) is house within the Cancer Imaging Program (CIP) of the Division of Cancer Treatment and Diagnosis (DCTD) at the National Cancer Institute (NCI). NSDB develops and implements programs with and for the extramural research community related to the use of nanotechnology in cancer and medicine.


The mission of the Nanodelivery Systems and Devices Branch is to strategically develop, fund, and administer initiatives aimed at solving cancer biology and oncology problems with nanotechnology solutions.

The overarching goal of these initiatives is to develop innovative nanotechnologies for cancer prevention, diagnosis, control, and treatment and ranging from discovery through clinical translation.

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