| Phase I: Preconditioning
|
Oral infections: dental caries, endodontic infections, periodontal disease (gingivitis, periodontitis), mucosal infections (i.e., viral, fungal, bacterial). |
| Gingival leukemic infiltrates. |
| Metastatic cancer. |
| Oral bleeding. |
| Oral ulceration: aphthous ulcers, erythema multiforme. |
| Temporomandibular dysfunction. |
| Phase II: Conditioning Neutropenic Phase |
Oropharyngeal mucositis. |
| Oral infections: mucosal infections (i.e., viral, fungal, bacterial), periodontal infections. |
| Hemorrhage. |
|
Xerostomia. |
| Taste dysfunction. |
| Neurotoxicity: dental pain, muscle tremor (e.g., jaws, tongue). |
| Temporomandibular dysfunction:
jaw pain, headache, joint pain. |
| Phase III: Engraftment
Hematopoietic Recovery |
Oral infections: mucosal infections (i.e., viral, fungal, bacterial). |
|
Acute GVHD.
|
| Xerostomia.
|
| Hemorrhage. |
| Neurotoxicity:
dental pain,
muscle tremor (e.g., jaws, tongue).
|
| Temporomandibular dysfunction: jaw pain, headache, joint pain. |
| Granulomas/papillomas. |
| Phase IV: Immune
Reconstitution
Late Posttransplant |
Oral infections: mucosal infections (i.e., viral, fungal, bacterial). |
| Chronic GVHD. |
| Dental/skeletal growth and development
alterations (pediatric patients). |
| Xerostomia. |
| Relapse-related oral lesions. |
| Second malignancies. |
| Phase V: Long-term Survival |
Relapse or second malignancies. |
| Dental/skeletal growth and development
alterations. |