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Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®)

  • Last Modified: 04/24/2014

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Oral Complications in Second Cancers

Cancer survivors who received chemotherapy or a transplant or who underwent radiation therapy are at risk of developing a second cancer later in life. Oral squamous cell cancer is the most common second oral cancer in transplant patients. The lips and tongue are the areas that are affected most often.

Second cancers are more common in patients treated for leukemia or lymphoma, Multiple myeloma patients who received a stem cell transplant using their own stem cells sometimes develop an oral plasmacytoma.

Patients who received a transplant should see a doctor if they have swollen lymph nodes or lumps in soft tissue areas. This could be a sign of a second cancer.