Oral Complications Not Related to Chemotherapy or Radiation Therapy
Key Points for This Section
Certain drugs used to treat cancer and other bone problems are linked to bone loss in the mouth.
Some drugs break down bone tissue in the mouth. This is called osteonecrosis of the jaw (ONJ). ONJ can also cause infection. Symptoms include pain and inflamed lesions in the mouth, where areas of damaged bone may show.
Drugs that may cause ONJ include the following:
- Bisphosphonates: Drugs given to some patients whose cancer has spread to the bones. They are used to decrease pain and the risk of broken bones. (See the PDQ summary on Pain for more information.) Bisphosphonates are also used to treat hypercalcemia (too much calcium in the blood). Bisphosphonates commonly used include zoledronic acid, pamidronate, and alendronate.
- Denosumab: A drug used to prevent or treat certain bone problems. Denosumab is a type of monoclonal antibody.
- Angiogenesis inhibitors: Drugs or substances that keep new blood vessels from forming. In cancer treatment, angiogenesis inhibitors may prevent the growth of new blood vessels that tumors need to grow. Some of the angiogenesis inhibitors that may cause ONJ are bevacizumab, sunitinib, and sorafenib.
It's important for the health care team to know if a patient has been treated with these drugs. Cancer that has spread to the jawbone can look like ONJ. A biopsy may be needed to find out the cause of the ONJ.
ONJ is not a common condition. It occurs more often in patients who receive bisphosphonates or denosumab by injection than in patients who take them by mouth. Taking bisphosphonates, denosumab, or angiogenesis inhibitors increases the risk of ONJ. The risk of ONJ is much greater when angiogenesis inhibitors and bisphosphonates are used together.
The following may also increase the risk of ONJ:
- Having teeth removed.
- Wearing dentures that do not fit well.
- Having multiple myeloma.
Treatment of ONJ usually includes treating the infection and good dental hygiene.
Treatment of ONJ may include the following:
During treatment for ONJ, you should continue to brush and floss after meals to keep your mouth very clean. It is best to avoid tobacco use while ONJ is healing. (See the PDQ summary on Smoking in Cancer Care for information on why it's important for cancer patients to quit smoking.)
You and your doctor can decide whether you should stop using medicines that cause ONJ, based on the effect it would have on your general health.