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Table 2. Major Histopathological Categories of Non-Hodgkin Lymphoma in Children and Adolescentsa

Category (WHO Classification/ Updated REAL) Category (Working Formulation) Immuno-phenotype  Clinical Presentation  Chromosome Translocation  Genes Affected 
Burkitt and Burkitt-like lymphomasML small noncleaved cellMature B cellIntra-abdominal (sporadic), head and neck (non-jaw, sporadic), jaw (endemic), bone marrow, CNSt(8;14)(q24;q32), t(2;8)(p11;q24), t(8;22)(q24;q11)C-MYC, IGH, IGK, IGL
Diffuse large B-cell lymphomaML large cellMature B cell; maybe CD30+Nodal, abdominal, bone, primary CNS (when associated with immunodeficiency), mediastinalNo consistent cytogenetic abnormality identified
Lymphoblastic lymphoma, precursor T-cell leukemia, or precursor B-cell lymphomaLymphoblastic convoluted and non-convolutedPre-T cellMediastinal, bone marrowMTS1/p16ink4a; Deletion TAL1 t(1;14)(p34;q11), t(11;14)(p13;q11)TAL1, TCRAO, RHOMB1, HOX11
Pre-B cellSkin, bone, mediastinal
Anaplastic large cell lymphoma, systemicML immunoblastic or ML largeCD30+ (Ki-1+)Variable, but systemic symptoms often prominentt(2;5)(p23;q35); less common variant translocations involving ALKALK, NPM
T cell or null cell
Anaplastic large cell lymphoma, cutaneousCD30+ (Ki-usually)Skin only; single or multiple lesionsLacks t(2;5)
T cell

CNS = central nervous system; ML = malignant lymphoma; REAL = Revised European-American Lymphoma; WHO = World Health Organization.
aAdapted from Percy et al.[2]


  1. Percy CL, Smith MA, Linet M, et al.: Lymphomas and reticuloendothelial neoplasms. In: Ries LA, Smith MA, Gurney JG, et al., eds.: Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. Bethesda, Md: National Cancer Institute, SEER Program, 1999. NIH Pub.No. 99-4649., pp 35-50. Also available online. Last accessed April 03, 2014.