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Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)

  • Updated: 04/04/2014

Table 3. Outcome According to Treatment Protocol for Adolescents and Young Adults with ALL

Site and Study Group Adolescent and Young Adult Patients (No.) Median age (y) Survival (%) 
United States [29]
CCG (Pediatric)1971667, OS 7 y
CALGB (Adult)1241946
France [35]
FRALLE 93 (Pediatric)771667 EFS
LALA 941001841
Italy [36]
AEIOP (Pediatric)1501580, OS 2 y
GIMEMA (Adult)951671
Netherlands [37]
DCOG (Pediatric)471271 EFS
HOVON442038
Sweden [38]
NOPHO 92 (Pediatric)361674, OS 5 y
Adult ALL991839
United Kingdom [32]
MRC ALL (Pediatric)6115–1771, OS 5 y
UKALL XII (Adult)6715–1756

ALL = acute lymphoblastic leukemia; EFS = event-free survival; OS = overall survival.
AEIOP = Associazione Italiana Ematologia Oncologia Pediatrica; CALGB = Cancer and Leukemia Group B; CCG = Children's Cancer Group; DCOG = Dutch Childhood Oncology Group; FRALLE = French Acute Lymphoblastic Leukaemia; GIMEMA = Gruppo Italiano Malattie e Matologiche dell'Adulto; HOVON = Dutch-Belgian Hemato-Oncology Cooperative Group; LALA = France-Belgium Group for Lymphoblastic Acute Leukemia in Adults; MRC = Medical Research Council (United Kingdom); NOPHO = Nordic Society for Pediatric Hematology and Oncology; UKALL = United Kingdom Acute Lymphoblastic Leukaemia.

References

  1. Stock W, La M, Sanford B, et al.: What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies. Blood 112 (5): 1646-54, 2008.  [PUBMED Abstract]

  2. Ramanujachar R, Richards S, Hann I, et al.: Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials. Pediatr Blood Cancer 48 (3): 254-61, 2007.  [PUBMED Abstract]

  3. Boissel N, Auclerc MF, Lhéritier V, et al.: Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J Clin Oncol 21 (5): 774-80, 2003.  [PUBMED Abstract]

  4. Testi AM, Valsecchi MG, Conter V, et al.: Difference in outcome of adolescents with acute lymphoblastic leukemia (ALL) enrolled in pediatric (AIEOP) and adult (GIMEMA) protocols. [Abstract] Blood 104: A-1954, 2004. 

  5. de Bont JM, van der Holt B, Dekker AW, et al.: [Adolescents with acute lymphatic leukaemia achieve significantly better results when treated following Dutch paediatric oncology protocols than with adult protocols]. Ned Tijdschr Geneeskd 149 (8): 400-6, 2005.  [PUBMED Abstract]

  6. Hallböök H, Gustafsson G, Smedmyr B, et al.: Treatment outcome in young adults and children >10 years of age with acute lymphoblastic leukemia in Sweden: a comparison between a pediatric protocol and an adult protocol. Cancer 107 (7): 1551-61, 2006.  [PUBMED Abstract]