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Table 2. Criteria Used for the Classification of Risk Groups in Childhood Hodgkin Lymphoma Clinical Trialsa

Trial Low Risk Intermediate Risk High Risk 
Children's Oncology Group
AHOD0031 [20]IA bulk or E; IB; IIA bulk or E; IIB; IIIA, IVA
AHOD0431 [21]IA, IIA with no bulk
C5942 [22]IA, IB, IIA with no bulk, no hilar nodes and <4 sitesIA, IB, IIA with bulk, hilar nodes or ≥4 sites; IIIIV
C59704 [23]IIB/IIIB with bulk, IV
P9425/P9426 [24]IA, IIA with no bulkIB, IIA, IIIA1 with bulk; IIIA2IIB, IIIB, IV
German Multicenter/Euronet
Stanford/St. Jude/Dana-Farber Cancer Institute Consortium
HOD05 IB, IIIA, IA/IIA with E, ≥3 sites or bulk
HOD08 IA, IIA with no bulk, E and <3 sites

E = extralymphatic.
aAdapted from Kelly.[19]


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