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Childhood Hodgkin Lymphoma Treatment (PDQ®)

  • Updated: 08/22/2014

Table 9. Treatment Complications Observed in Hodgkin Lymphoma Survivors

Health Effects  Predisposing Therapy Clinical Manifestations 
Oral/dental Any chemotherapy in a patient who has not developed permanent dentitionDental maldevelopment (tooth/root agenesis, microdontia, root thinning and shortening, enamel dysplasia)
Radiation impacting oral cavity and salivary glandsSalivary gland dysfunction
Accelerated dental decay
Periodontal disease
Thyroid Radiation impacting thyroid glandHypothyroidism
Thyroid nodules
Cardiovascular Radiation impacting cardiovascular structuresSubclinical left ventricular dysfunction
Heart valve dysfunction
Conduction disorder
Coronary, carotid, subclavian vascular disease
Myocardial infarction
Anthracycline chemotherapySubclinical left ventricular dysfunction
Congestive heart failure
Pulmonary Radiation impacting the lungsSubclinical pulmonary dysfunction
BleomycinPulmonary fibrosis
Musculoskeletal Radiation of musculoskeletal tissues in any patient who is not skeletally matureGrowth impairment
GlucocorticosteroidsBone mineral density deficit
Reproductive Alkylating agent chemotherapyHypogonadism
Gonadal irradiationInfertility
Immune SplenectomyOverwhelming post-splenectomy sepsis
Subsequent neoplasm or disease Alkylating agent chemotherapyMyelodysplasia/acute myeloid leukemia
EpipodophyllotoxinsMyelodysplasia/acute myeloid leukemia
RadiationSolid benign and malignant neoplasms