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Table 1. Risk Factors Associated With Hepatoblastoma and Hepatocellular Carcinoma

Associated Disorder  Hepatoblastoma Hepatocellular Carcinoma 
Aicardi syndrome [15]X
Alagille syndrome [16]X
Beckwith-Wiedemann syndrome [17,18]X
Familial adenomatous polyposis [19-21]X
Glycogen storage diseases I–IV [22]XX
Hepatitis B and C [23-25]X
Low-birth-weight infants [5-7,26]X
Progressive familial intrahepatic cholestasis [27,28]X
Trisomy 18, other trisomies [29]X
Tyrosinemia [30]X


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  9. Siciliano M, De Candia E, Ballarin S, et al.: Hepatocellular carcinoma complicating liver cirrhosis in type IIIa glycogen storage disease. J Clin Gastroenterol 31 (1): 80-2, 2000.  [PUBMED Abstract]

  10. Ni YH, Chang MH, Hsu HY, et al.: Hepatocellular carcinoma in childhood. Clinical manifestations and prognosis. Cancer 68 (8): 1737-41, 1991.  [PUBMED Abstract]

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  14. Alonso EM, Snover DC, Montag A, et al.: Histologic pathology of the liver in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 18 (2): 128-33, 1994.  [PUBMED Abstract]

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  16. van Spronsen FJ, Bijleveld CM, van Maldegem BT, et al.: Hepatocellular carcinoma in hereditary tyrosinemia type I despite 2-(2 nitro-4-3 trifluoro- methylbenzoyl)-1, 3-cyclohexanedione treatment. J Pediatr Gastroenterol Nutr 40 (1): 90-3, 2005.  [PUBMED Abstract]