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Childhood Liver Cancer Treatment (PDQ®)

  • Updated: 08/18/2014

Table 1. Risk Factors Associated With Hepatoblastoma and Hepatocellular Carcinoma

Associated Disorder  Hepatoblastoma Hepatocellular Carcinoma 
Aicardi syndrome [15]X
Alagille syndrome [16]X
Beckwith-Wiedemann syndrome [17,18]X
Familial adenomatous polyposis [19-21]X
Glycogen storage diseases I–IV [22]XX
Hepatitis B and C [23-25]X
Low-birth-weight infants [5-7,26]X
Progressive familial intrahepatic cholestasis [27,28]X
Trisomy 18, other trisomies [29]X
Tyrosinemia [30]X

References

  1. Ikeda H, Hachitanda Y, Tanimura M, et al.: Development of unfavorable hepatoblastoma in children of very low birth weight: results of a surgical and pathologic review. Cancer 82 (9): 1789-96, 1998.  [PUBMED Abstract]

  2. McLaughlin CC, Baptiste MS, Schymura MJ, et al.: Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol 163 (9): 818-28, 2006.  [PUBMED Abstract]

  3. Kamien BA, Gabbett MT: Aicardi syndrome associated with hepatoblastoma and pulmonary sequestration. Am J Med Genet A 149A (8): 1850-2, 2009.  [PUBMED Abstract]

  4. Keeffe EB, Pinson CW, Ragsdale J, et al.: Hepatocellular carcinoma in arteriohepatic dysplasia. Am J Gastroenterol 88 (9): 1446-9, 1993.  [PUBMED Abstract]

  5. DeBaun MR, Tucker MA: Risk of cancer during the first four years of life in children from The Beckwith-Wiedemann Syndrome Registry. J Pediatr 132 (3 Pt 1): 398-400, 1998.  [PUBMED Abstract]

  6. Weksberg R, Shuman C, Smith AC: Beckwith-Wiedemann syndrome. Am J Med Genet C Semin Med Genet 137C (1): 12-23, 2005.  [PUBMED Abstract]

  7. Iwama T, Mishima Y: Mortality in young first-degree relatives of patients with familial adenomatous polyposis. Cancer 73 (8): 2065-8, 1994.  [PUBMED Abstract]

  8. Giardiello FM, Petersen GM, Brensinger JD, et al.: Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 39 (96): 867-9, 1996.  [PUBMED Abstract]

  9. Siciliano M, De Candia E, Ballarin S, et al.: Hepatocellular carcinoma complicating liver cirrhosis in type IIIa glycogen storage disease. J Clin Gastroenterol 31 (1): 80-2, 2000.  [PUBMED Abstract]

  10. Ni YH, Chang MH, Hsu HY, et al.: Hepatocellular carcinoma in childhood. Clinical manifestations and prognosis. Cancer 68 (8): 1737-41, 1991.  [PUBMED Abstract]

  11. González-Peralta RP, Langham MR Jr, Andres JM, et al.: Hepatocellular carcinoma in 2 young adolescents with chronic hepatitis C. J Pediatr Gastroenterol Nutr 48 (5): 630-5, 2009.  [PUBMED Abstract]

  12. Spector LG, Birch J: The epidemiology of hepatoblastoma. Pediatr Blood Cancer 59 (5): 776-9, 2012.  [PUBMED Abstract]

  13. Knisely AS, Strautnieks SS, Meier Y, et al.: Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency. Hepatology 44 (2): 478-86, 2006.  [PUBMED Abstract]

  14. Alonso EM, Snover DC, Montag A, et al.: Histologic pathology of the liver in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 18 (2): 128-33, 1994.  [PUBMED Abstract]

  15. Maruyama K, Ikeda H, Koizumi T: Hepatoblastoma associated with trisomy 18 syndrome: a case report and a review of the literature. Pediatr Int 43 (3): 302-5, 2001.  [PUBMED Abstract]

  16. van Spronsen FJ, Bijleveld CM, van Maldegem BT, et al.: Hepatocellular carcinoma in hereditary tyrosinemia type I despite 2-(2 nitro-4-3 trifluoro- methylbenzoyl)-1, 3-cyclohexanedione treatment. J Pediatr Gastroenterol Nutr 40 (1): 90-3, 2005.  [PUBMED Abstract]