Current Clinical Trials

Standard treatment options:

1. Surgery.
2. Chemoradiation.

Treatment option under clinical evaluation:

• Chemoradiation with subsequent surgery, such as in the RTOG-8501 ¹ trial.[1-3]

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II esophageal cancer ². The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site ³.

References

1. Cooper JS, Guo MD, Herskovic A, et al.: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 281 (17): 1623-7, 1999.  [PUBMED Abstract]
   
   
2. Herskovic A, Al-Sarraf M: Combination of 5-Fluorouracil and Radiation in Esophageal Cancer. Semin Radiat Oncol 7 (4): 283-290, 1997.  [PUBMED Abstract]
   
   
3. Ajani JA, Komaki R, Putnam JB, et al.: A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction. Cancer 92 (2): 279-86, 2001.  [PUBMED Abstract]