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Unusual Cancers of Childhood Treatment (PDQ®)

  • Updated: 05/02/2014

Table 1. Characteristics of Thyroid Carcinoma in Children and Adolescents Versus Adultsa

Characteristic Children and Adolescents (%) Adults (%) 
aAdapted from Yamashita et al.[59]
Histologic subtype:
Papillary67–9885–90
Follicular4–23<10
Medullary2–83
Poorly differentiated<0.12–7
Gene rearrangements:
RET/PTC 38–870–35
NTRK 1 5–115–13
AKAP9-BRAF 111
PAX8-PPARG Unknown0–50
Point mutations:
BRAF 0–60–43
RAS family0–1625–69
GNAS 011
TP53 0–230–20
Other:
Multicentric30–5040–56
Lymph node involvement30–905–55
Extrathyroid extension24–5116–46
Vascular invasion<3114–37
Distant metastases10–205–10

References

  1. Yamashita S, Saenko V: Mechanisms of Disease: molecular genetics of childhood thyroid cancers. Nat Clin Pract Endocrinol Metab 3 (5): 422-9, 2007.  [PUBMED Abstract]