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Table 3. Common Genetic Syndromes Associated With Adenomatous Polyposis

Syndrome  Gene Gene Function Hereditary Pattern 
Attenuated familial adenomatous polyposisAPC (5’ mutations), AXIN2Tumor suppressorDominant
Familial adenomatous polyposis (Gardner syndrome)APC Tumor suppressorDominant
Lynch syndrome (hereditary nonpolyposis colorectal cancer)MSH2, MLH1, MSH6, PMS2, EPCAM Repair/stabilityDominant
Li-Fraumeni syndromeTP53 (p53)Tumor suppressorDominant
MYH-associated polyposisMYH (MUTYH)Repair/stabilityRecessive
Turcot syndromeAPC Tumor suppressorDominant
MLH1 Repair/stabilityDominant