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Table 4. Common Genetic Syndromes Associated With Hamartomatous Polyps

Syndrome Gene Gene Function Hereditary Pattern 
Cowden syndromePTEN Tumor suppressorDominant
Juvenile polyposis syndromeBMPR1A, SMAD4, ENG Tumor suppressorDominant
Peutz-Jeghers syndromeSTK11 Tumor suppressorDominant