Changes to This Summary (01/29/2014)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that in well-differentiated thyroid cancer, male gender, large tumor size, and distant metastases have been found to have prognostic significance for early mortality; however, even patients in the highest risk group who had distant metastases had excellent survival at 90% (cited Shayota et al. as reference 65).
Added Molinaro et al. as reference 73.
Added text to state that treatment with the mTOR inhibitor everolimus has been reported to be associated with a decrease in the size of rhabdomyomas in patients with tuberous sclerosis.
Added text to state that in a Brazilian study, neonatal screening for the TP53 R337H mutation, which is prevalent in the region, identified 461 carriers among 171,649 of the newborns who were screened. Carriers and relatives younger than 15 years were offered clinical screening. Adrenocortical tumors identified in the screening participants were smaller and more curable than the tumors found in carriers who did not elect to participate in screening (cited Custódio et al. as reference 15).
Added text to state that hyperestrogenism can also occur in patients with adrenocortical tumors (cited Ghazi et al. as reference 26).
Added text to state that high-grade, invasive, urothelial carcinomas are extremely rare in young patients (cited Stanton et al. as reference 3).
Added text to state that surgery and chemotherapy have been used to treat ovarian surface epithelial neoplasms.
This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.