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Cuadro 1. Regímenes de quimioterapia de combinación generalmente utilizados en niños y adultos jóvenes con linfoma de Hodgkin
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Régimen de quimioterapia
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Fármacos correspondientes
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| ABVD [19] |
doxorrubicina (Adriamicina), bleomicina, vinblastina, dacarbazina |
| ABVE (DBVE) [14] |
doxorrubicina (Adriamicina), bleomicina, vincristina, etopósido |
| VAMP [15] |
vincristina, doxorrubicina (Adriamicina), metotrexato, prednisona |
| OPPA +/- COPP (mujeres) [20] |
vincristina (Oncovin), prednisona, procarbazina, doxorrubicina (Adriamicina), ciclofosfamida, vincristina (Oncovin), prednisona, procarbazina |
| OEPA +/- COPP (hombres) [20] |
vincristina (Oncovin), etopósido, prednisona, doxorrubicina (Adriamicina), ciclofosfamida, vincristina (Oncovin), prednisona, procarbazina |
| COPP/ABV [9] |
ciclofosfamida, vincristina (Oncovin), prednisona, procarbazina, doxorrubicina (Adriamicina), bleomicina, vinblastina |
| BEACOPP (estadio avanzado) [21] |
bleomicina, etopósido, doxorrubicina (Adriamicina), ciclofosfamida, vincristina (Oncovin), prednisona, procarbazina |
| COP(P) (con prednisona o sin esta) |
ciclofosfamida, vincristina (Oncovin), ± prednisona, procarbazina |
| CHOP |
ciclofosfamida, doxorrubicina (Adriamicina), vincristina (Oncovin), prednisona |
| ABVE-PC (DBVE-PC) [22] |
doxorrubicina (Adriamicina), bleomicina, vincristina, etopósido, prednisona, ciclofosfamida |
| MOPP/ABV [23] |
mecloretamina, vincristina (Oncovin), procarbazina, prednisona, doxorrubicina (Adriamycin), bleomicina, vinblastina |
Bibliografía
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Nachman JB, Sposto R, Herzog P, et al.: Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy. J Clin Oncol 20 (18): 3765-71, 2002.
[PUBMED Abstract]
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Tebbi CK, Mendenhall N, London WB, et al.: Treatment of stage I, IIA, IIIA1 pediatric Hodgkin disease with doxorubicin, bleomycin, vincristine and etoposide (DBVE) and radiation: a Pediatric Oncology Group (POG) study. Pediatr Blood Cancer 46 (2): 198-202, 2006.
[PUBMED Abstract]
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Donaldson SS, Link MP, Weinstein HJ, et al.: Final results of a prospective clinical trial with VAMP and low-dose involved-field radiation for children with low-risk Hodgkin's disease. J Clin Oncol 25 (3): 332-7, 2007.
[PUBMED Abstract]
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Behrendt H, Brinkhuis M, Van Leeuwen EF: Treatment of childhood Hodgkin's disease with ABVD without radiotherapy. Med Pediatr Oncol 26 (4): 244-8, 1996.
[PUBMED Abstract]
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Rühl U, Albrecht M, Dieckmann K, et al.: Response-adapted radiotherapy in the treatment of pediatric Hodgkin's disease: an interim report at 5 years of the German GPOH-HD 95 trial. Int J Radiat Oncol Biol Phys 51 (5): 1209-18, 2001.
[PUBMED Abstract]
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Kelly KM, Hutchinson RJ, Sposto R, et al.: Feasibility of upfront dose-intensive chemotherapy in children with advanced-stage Hodgkin's lymphoma: preliminary results from the Children's Cancer Group Study CCG-59704. Ann Oncol 13 (Suppl 1): 107-11, 2002.
[PUBMED Abstract]
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Schwartz CL: Special issues in pediatric Hodgkin's disease. Eur J Haematol Suppl (66): 55-62, 2005.
[PUBMED Abstract]
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Chow LM, Nathan PC, Hodgson DC, et al.: Survival and late effects in children with Hodgkin's lymphoma treated with MOPP/ABV and low-dose, extended-field irradiation. J Clin Oncol 24 (36): 5735-41, 2006.
[PUBMED Abstract]
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