Cuadro 8. Linfoma de Hodgkin con predominio linfocítico nodular
| Quimioterapia (No. de cursos)a | Radiación (Gy) | Número de pacientes | Supervivencia sin complicaciones (número de años de seguimiento) | Supervivencia (número de años de seguimiento) |
| COPP/ABV (4)b [23] | Ninguno | 52 | 96% (5) | 100% (5) |
| IFRT (21) | 29 | 100% (5) | ||
| CVP (3) [45] | Ninguno | 55 | 74% (5) | 100% (5) |
| VAMP (4)c [49] | Ninguno | 26 | 87.5% (5) | N/A |
| IFRT (25) | 6 | |||
| VAMP (4) [41] | IFRT (15–25.5) | 33 | 100% (10) | 100% (10) |
| Ningunod [21] | Ninguno | 51 | 67% (2) | 100% (2) |
| DBVE (2–4)c [43] | Ninguno | 26 | 94% (8) | 100% (8) |
| IFRT (25.5) |
| IFRT = radioterapia con compromiso de campo; N/A = no corresponde; No. = número. | ||||
| aPara mayor información sobre los regímenes quimioterapéuticos, consultar el Cuadro . | ||||
| bAsignación o no a radioterapia con base en la respuesta al tratamiento. | ||||
| cAsignación con base en la respuesta clínica. | ||||
| dExtirpación de todos los ganglios linfáticos comprometidos. |
Bibliografía
- Mauz-Körholz C, Gorde-Grosjean S, Hasenclever D, et al.: Resection alone in 58 children with limited stage, lymphocyte-predominant Hodgkin lymphoma-experience from the European network group on pediatric Hodgkin lymphoma. Cancer 110 (1): 179-85, 2007. [PUBMED Abstract]
- Appel BE, Chen L, Buxton A, et al.: Impact of low-dose involved-field radiation therapy on pediatric patients with lymphocyte-predominant Hodgkin lymphoma treated with chemotherapy: a report from the Children's Oncology Group. Pediatr Blood Cancer 59 (7): 1284-9, 2012. [PUBMED Abstract]
- Donaldson SS, Link MP, Weinstein HJ, et al.: Final results of a prospective clinical trial with VAMP and low-dose involved-field radiation for children with low-risk Hodgkin's disease. J Clin Oncol 25 (3): 332-7, 2007. [PUBMED Abstract]
- Tebbi CK, Mendenhall NP, London WB, et al.: Response-dependent and reduced treatment in lower risk Hodgkin lymphoma in children and adolescents, results of P9426: a report from the Children's Oncology Group. Pediatr Blood Cancer 59 (7): 1259-65, 2012. [PUBMED Abstract]
- Shankar A, Hall GW, Gorde-Grosjean S, et al.: Treatment outcome after low intensity chemotherapy [CVP] in children and adolescents with early stage nodular lymphocyte predominant Hodgkin's lymphoma - an Anglo-French collaborative report. Eur J Cancer 48 (11): 1700-6, 2012. [PUBMED Abstract]
- Metzger ML, Weinstein HJ, Hudson MM, et al.: Association between radiotherapy vs no radiotherapy based on early response to VAMP chemotherapy and survival among children with favorable-risk Hodgkin lymphoma. JAMA 307 (24): 2609-16, 2012. [PUBMED Abstract]
