CTD² Data Portal

Data generated by the CTD² Network is available to the community in the Index of NCI Studies (INS).

CTD² Institution Data
CTD2 Institution	INS Data Title	Cancer Type	Related PMID(s)
Broad Institute	Screening for Dependencies in Cancer Cell Lines Using Small Molecules	Multiple Cancer Types	23993102 & 26482930
Columbia University	A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies	Multiple Cancer Types	37061969
Columbia University	Computational Human High-grade Glioblastoma Multiform (GBM) Interactome - miRNA (Post-transcriptional) Layer	Brain Cancer	22000015
Columbia University	Core Regulatory Elements of High-risk Neuroblastoma	Neuroblastoma	29510988
Columbia University	CTD² Pancancer Chemosensitivity Challenge	Multiple Cancer Types	N/A
Columbia University	CTD² Pancancer Drug Activity Challenge	Multiple Cancer Types	35106508
Columbia University	Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia (T-ALL)	Leukemias	24291004
Columbia University	Expression Profile of Neuroendocrine Tumor Cell-line Perturbed with Small Molecules	Multiple Cancer Types	29915428
Columbia University	Kinases Controlling Stability of the Oncogenic MYCN Protein	Multiple Cancer Types	38116412
Columbia University	NaRnEA: An Information Theoretic Framework for Gene Set Analysis	Multiple Cancer Types	36981431
Columbia University	OncoLoop: A Network-based Precision Cancer Medicine Framework	Multiple Cancer Types	36374194
Columbia University	Pharmacological Targeting of Mechanistic Dependencies in Neuroendocrine Tumors	Multiple Cancer Types	N/A
Columbia University	PLATE-seq for Genome-wide Regulatory Network Analysis of High-throughput Screens	Multiple Cancer Types	28740083
Columbia University	Proteome-Wide Signaling-network Analysis in Lung Adenocarcinoma	Lung Cancer	30615629
Columbia University	Subtype-Selective Prenylated Isoflavonoids Disrupt Regulatory Drivers of MYCN-Amplified Cancers	Multiple Cancer Types	38061356
Columbia University	Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators	Multiple Cancer Types	37116491
Columbia University	Tumor-selective Effects of Active RAS Inhibition in Pancreatic Ductal Adenocarcinoma	Pancreatic Cancer	38061356
Dana-Farber	Computational Correction of Copy-number Effect in CRISPR-Cas9 Screens of Cancer Cells	Multiple Cancer Types	29083409
Dana-Farber	Discovery of Novel Oncogenes: Across Cancer Types	Multiple Cancer Types	23764425
Dana-Farber	Discovery of Novel Oncogenes: High-grade Serous Ovarian Cancer	Ovarian Cancer	25368431
Dana-Farber	Discovery of Novel Oncogenes: Ovarian Cancer	Ovarian Cancer	24385586
Dana-Farber	Discovery of Resistance Mechanisms: Breast Cancer	Breast Cancer	24909179
Dana-Farber	Discovery of Resistance Mechanisms: Colon Cancer	Colorectal Cancer	24954536
Dana-Farber	Genome-wide shRNA Screens with DEMETER Inferred Gene Effects	Multiple Cancer Types	28753430
Dana-Farber	Identification of Therapeutic Targets Across Cancer Types: ATARiS	Multiple Cancer Types	21746896, 25984343 & 23269662
Dana-Farber	Identification of Therapeutic Targets Across Cancer Types: Project Achilles	Multiple Cancer Types	22901813
Dana-Farber	Identification of Therapeutic Targets: Adult and Pediatric Cancer Types	Multiple Cancer Types	27260156
Dana-Farber	Identification of Therapeutic Targets in KRAS Driven Lung Cancer	Lung Cancer	19847166
Dana-Farber	Identification of Therapeutic Targets in Ovarian Cancer	Ovarian Cancer	25535366 & 22896676
Dana-Farber	Mapping the Function of Rare Oncogenic Variants	Multiple Cancer Types	27147599
Dana-Farber	SMAD4 Represses FOSL1 Expression and Pancreatic Cancer Metastatic Colonization	Pancreatic Cancer	34320363
Emory University	Discovering Protein-protein Interaction (PPI) Inducers to Restore the Lost Function of a Tumor Suppressor	Multiple Cancer Types	33326750
Emory University	Discovery of Novel MYC Protein Interactors with NanoPCA High-throughput Protein-protein Interaction Screening	Multiple Cancer Types	28087810
Emory University	Discovery of the First Chemical Tools to Regulate MKK3-mediated MYC Activation in Cancer	Multiple Cancer Types	34333394
Emory University	High-throughput Protein-protein Interaction Analysis for Hippo Pathway Profiling	Multiple Cancer Types	26578655
Emory University	High-throughput Protein-protein Interaction Dataset for Lung Cancer-Associated Genes	Lung Cancer	28205554
Emory University	MEDICI (Mining Essentiality Data to Identify Critical Interactions) for Cancer Drug Target Discovery and Development	Multiple Cancer Types	28118365
Emory University	mRNA-seq Analysis of Formalin-fixed, Paraffin-embedded Prostate Cancer Tissues	Prostate Cancer	24713434
Emory University	Systematic Discovery of Mutation-Directed Neo-Protein-Protein Interactions in Cancer	Multiple Cancer Types	35512704
Emory University	LC-MS Analysis of PRAS40 Protein-Protein Interactions	Multiple Cancer Types	24704832
Emory University	Identification of Protein-Protein Interaction Inhibitors as Potential Anti-tumor Immunity Enhancers	Multiple Cancer Types	N/A
Fred Hutch	Functional Exploration of the Druggable Genome in Cisplatin Resistant Ovarian Cancer	Ovarian Cancer	N/A
Fred Hutch	Functional Exploration of the Druggable Genome in Head and Neck Squamous Cell Carcinoma	Head and Neck Cancer	29599409
Fred Hutch	Functional Exploration of the Druggable Genome in MYCN Amplified and Non-amplified Neuroblastoma	Neuroblastoma	N/A
Fred Hutch	Functional Exploration of the Druggable Genome in Pancreatic Ductal Adenocarcinoma	Pancreatic Cancer	N/A
Fred Hutch	Functional Exploration of the Kinome in MYC Driven Ovarian Cancer	Ovarian Cancer	N/A
Fred Hutch	Functional Exploration of the Kinome in Pancreatic Ductal Adenocarcinoma	Pancreatic Cancer	N/A
Fred Hutch	Functional Landscape of the Human Kinome in MYCN Amplified and Non-amplified Neuroblastoma	Neuroblastoma	N/A
Fred Hutch	Genetic Disruption of CTCF Destabilizes DNA Methylation	Multiple Cancer Types	24794443
Fred Hutch	Identification of Candidate Therapeutic Targets in Head and Neck Cancer Using Functional Kinomics	Head and Neck Cancer	25125259 & 29599409
Fred Hutch	Identification of Drug Targets for Combination Therapy with Retinoic Acid in Neuroblastoma	Neuroblastoma	N/A
Fred Hutch	Identification of Novel Targets and Sensitizers to the PARP Inhibitor Rucaparib in Ovarian Cancer	Ovarian Cancer	32927276
Fred Hutch	Kinome-wide siRNA Screens (screen 1) to Discover Novel Vulnerabilities in Ras/Tp53 Mutant Murine Squamous Cell Carcinomas	Squamous Cell Carcinoma	N/A
Fred Hutch	Kinome-wide siRNA Screens (screen 2) to Discover Novel Vulnerabilities in Ras/Tp53	Squamous Cell Carcinoma	N/A
Fred Hutch	NanoString Profiling of MUC16 in Serous Ovarian Cancer, Benign Ovarian Tumor and Normal Tissues	Ovarian Cancer	N/A
Fred Hutch	Spectral Nature of Fusion Transcripts in Serous Ovarian Cancer	Ovarian Cancer	N/A
Fred Hutch	Transcript Splicing in Ovarian Cancer and in Diverse Normal Tissues	Ovarian Cancer	N/A
Johns Hopkins University	E-cadherin Promotes Metastasis in Invasive Ductal Breast Cancer	Breast Cancer	31485072
Johns Hopkins University	Organoid Spectral Invasion and Population Genetics	Breast Cancer	31961880
MD Anderson	Characterization of PIK3R1 Neomorphic Mutations	Multiple Cancer Types	25284480
MD Anderson	High-throughput Screening Identifying Driving Mutations in Endometrial Cancer	Endometrial Cancer	23028188
MD Anderson	Informer Drug Library Screening Against Patient-derived PDGFRA Mutations	Multiple Cancer Types	N/A
MD Anderson	Phenotypic Examination of PIK3CA Allelic Series Using MCF10A Cell Sensor Platform	Breast Cancer	26627007
MD Anderson	Systematic Functional Annotation of Somatic Mutations in Cancer	Multiple Cancer Types	29533785
OHSU	C5aR1 Inhibition Reprograms Tumor Associated Macrophages and Reverses PARP Inhibitor Resistance in Breast Cancer	Breast Cancer	38802355
OHSU	Functional Genomic Landscape of Acute Myeloid Leukaemia	Leukemias	30333627
OHSU	In Vivo Functional Characterization of EGFR Variants Identifies Novel Drivers of Glioblastoma	Brain Cancer	36044040
OHSU	Large-scale Characterization of Drug Responses for Clinically Relevant Proteins in Cancer Cell Lines	Multiple Cancer Types	33157050
OHSU	Secondary Fusion Proteins as a Mechanism of BCR::ABL1 Kinase-independent Resistance in Chronic Myeloid Leukaemia	Leukemias	36264026
OHSU	Single Cell RNA Trajectory Analysis Reveals a CD9 Positive Cell State to Contribute to Exit from Stem Cell-like and Embryonic Diapause States and Transit to Drug Resistant States	Multiple Cancer Types	37542044
OHSU	Tumor-intrinsic SIRPA Promotes Sensitivity to Checkpoint Inhibition Immunotherapy in Melanoma	Melanoma	36332624
Stanford University	A CRISPR/Cas9-engineered ARID1A-deficient Human Gastric Cancer Organoid Model Reveals Essential and Non-essential Modes of Oncogenic Transformation	Multiple Cancer Types	33451982
Stanford University	Functional Screening of Amplification Outlier Oncogenes in Organoid Models of Early Tumorigenesis	Multiple Cancer Types	37922313
Stanford University	Identifying Methylation-Driven Genes in Colorectal Cancer	Colorectal Cancer	N/A
Stanford University	Organoid Modeling of the Tumor Immune Microenvironment	Multiple Cancer Types	30550791
Stanford University	Predicting DNA Methylation Patterns using Histopathology Images	Multiple Cancer Types	32194984
Stanford University	Quantifying the Timing of Metastatic Progression from Patient Genomic Data	Colorectal Cancer	31209394
Stanford University	Single-Cell Genomic Characterization of the Tumor Microenvironment of Gastric Cancer	Gastrointestinal Cancer	32060101
Stanford University	Tumor Microenvironment of Metastatic Colorectal Cancer	Colorectal Cancer	36239989
TGen	Glioblastoma Multiforme Orthotopic Xenograft Transcriptome	Brain Cancer	N/A
TGen	Identification of Pathways Enriched with Condition-specific Statistical Dependencies Across Four Subtypes of Glioblastoma Multiforme (GBM)	Brain Cancer	N/A
TGen	Quantified Cancer Cell Line Encyclopedia RNA-seq Data	Multiple Cancer Types	N/A
UCSF	A Quantitative Chemical-Genetic Interaction Map of Cancer Chemotherapy	Multiple Cancer Types	29669295
UCSF	Chemical-Genetic Interaction Mapping Strategy	Breast Cancer	25501949
UCSF	Construction of Directional Regulatory Networks Using Orthogonal CRISPR/Cas Screens	Multiple Cancer Types	29334369
UCSF	Expression Analysis of Superior Cervical Ganglion from Backcrossed TH-MYCN Transgenic Mice	Neuroblastoma	25437558
UCSF	Gene Expression Profiling of Normal Mouse Skin, Hras WT and Hras -/-	Multiple Cancer Types	N/A
UCSF	Human Neuroepithelial Stem Cells as a Model System for Medulloblastoma	Medulloblastoma	31204176
UCSF	Integrative Genomic Approaches in Neuroblastoma (NBL)	Neuroblastoma	25637275
UTSW	DRC Study of Natural Products Against Non-small Cell Lung Cancer (NSCLC) Cell Lines	Lung Cancer	N/A
UTSW	Functional Signature Ontology Tool: Triplicate Measurements of Reporter Gene Expression in Response to Individual Genetic and Chemical Perturbations in HCT116 Cells (Colon Cancer)	Colorectal Cancer	24129700
UTSW	High-throughput Screening of CTD² Network Informer Set (CNIS) Compounds Against Non-Small-Cell Lung Cancer (NSCLC) Cell Lines	Lung Cancer	N/A
UTSW	High-throughput siRNA Screening of a Non-small Cell Lung Cancer (NSCLC) Cell Line Panel	Lung Cancer	N/A
UTSW	Identification of ASCL1 as a Therapeutic Target for High-grade Neuroendocrine Lung Cancers	Lung Cancer	25267614
UTSW	Lung Cancer Oncogenotype-selective Drug Target Discovery (Natural Products Focus)	Lung Cancer	N/A
UTSW	NSCLC Cell Lines with Loss of SMARCA4 Expression are Hypersensitive to Inhibitors of Aurora Kinase A	Lung Cancer	28102363
UTSW	SW04428 is a Novel Topoisomerase 1 Inhibitor	Lung Cancer	24243015 & 26668189
UTSW	U01 Natural Products Screening	Lung Cancer	N/A