Access OCG Data

An overarching goal of the Office of Cancer Genomics (OCG) is to create genomics resources for the research community, and a key resource is data. OCG strives to generate high-quality, accessible genomic data and disseminate the data to the research community in accordance with National Institute of Health’s data sharing policies in a timely manner.

Data is generally made available to the public once OCG researchers have published an initial overview and analysis of the data. The majority of genomics data generated by OCG programs is available through the Genomic Data Commons (GDC). Analysis data and supplementary data files generated by program researchers is available through publication pages at the GDC. Raw and harmonized genomic characterization data (i.e., primary data), is available through the GDC Data Portal.

Data is available via open-access when possible. However, certain data which may contain patient-identifying information, such as raw DNA sequencing data, is controlled-access. GDC guidelines describe how to apply for access through NIH’s Database of Genotype and Phenotypes (dbGaP) with the study accession numbers below. Researchers using OCG program data in their work are also encouraged to check program descriptions for appropriate acknowledgement.

OCG Genomic Data Resources by Program

Program	Description	Data
CGCI	Clinical, biospecimen, and molecular characterization data for selected rare cancers (phs000235).	Primary data (Select CGCI program within GDC Cohort Builder) Publication supplementary files (GDC)
CTD²	Experimental data investigating cancer targets and drug combinations.	CTD² Dashboard (for summarized data) CTD² Data Portal (for raw primary data)
Exceptional Responders	Clinical, biospecimen, and molecular characterization data for patients with unexpected and long-lasting responses to treatment (phs001145).	Study publication Primary data (Select EXCEPTIONAL_RESPONDERS program within GDC Cohort Builder)
HCMI	Clinical, biospecimen, and molecular characterization data for patient-derived next-generation cancer models such as organoids (phs001486).	Model catalog Primary data (Select HCMI program within GDC Cohort Builder)
TARGET	Clinical, biospecimen, and molecular characterization data for pediatric cancers (phs000218).	Primary data (Select TARGET program within GDC Cohort Builder) Publication supplementary files (GDC)

TCGA & Continuing Analyses Genomic Data Resources

Topic	Description	Data
TCGA	Clinical, biospecimen, molecular characterization, and imaging data for samples from 11,000 patients spanning 33 cancer types. All primary TCGA and subsequently produced data can be accessed via phs000178.	Primary data (Select TCGA program within GDC Cohort Builder) Publication supplementary files (GDC)
PanCancer Atlas	A collection of studies analyzing TCGA data as a whole, investigating cross-cancer topics: cell of origin, oncogenic processes, and oncogenic pathways.	Publication collection (Cell Press) Publication supplementary files (GDC)
ATAC-seq	Genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from TCGA.	Primary data (Select ATAC-seq experimental strategy within Available Data of GDC Cohort Builder) Publication supplementary files (GDC)
Ancestry and Molecular Correlates	A study of ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among TCGA patients.	Publication supplementary files (GDC)