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Access CCG Data

An overarching goal of the Center for Cancer Genomics (CCG) is to create genomics resources for the research community, and a key resource is data. CCG strives to generate high-quality, accessible genomic data and disseminate the data to the research community in accordance with National Institute of Health’s data sharing policies in a timely manner. 

Data is generally made available to the public once CCG researchers have published an initial overview and analysis of the data. The majority of genomics data generated by CCG programs is available through the Genomic Data Commons (GDC). Analysis data and supplementary data files generated by program researchers is available through publication pages at the GDC. Raw and harmonized genomic characterization data (i.e., primary data), is available through the GDC Data Portal

Data is available via open-access when possible. However, certain data which may contain patient-identifying information, such as raw DNA sequencing data, is controlled-access. GDC guidelines describe how to apply for access through NIH’s Database of Genotype and Phenotypes (dbGaP) with the study accession numbers below. Researchers using CCG program data in their work are also encouraged to check program descriptions for appropriate acknowledgement.

CCG Genomic Data Resources by Program

Program Description Data

Clinical, biospecimen, and molecular characterization data for selected rare cancers (phs000235). 

CTD2 Experimental data investigating cancer targets and drug combinations.
Exceptional Responders Clinical, biospecimen, and molecular characterization data for patients with unexpected and long-lasting responses to treatment (phs001145).  
HCMI Clinical, biospecimen, and molecular characterization data for patient-derived next-generation cancer models such as organoids (phs001486).
TARGET Clinical, biospecimen, and molecular characterization data for pediatric cancers (phs000218). 

TCGA & Continuing Analyses Genomic Data Resources

Topic Description Data
TCGA Clinical, biospecimen, molecular characterization, and imaging data for samples from 11,000 patients spanning 33 cancer types. All primary TCGA and subsequently produced data can be accessed via phs000178.
PanCancer Atlas A collection of studies analyzing TCGA data as a whole, investigating  cross-cancer topics: cell of origin, oncogenic processes, and oncogenic pathways.

Genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from TCGA.

Ancestry and Molecular Correlates A study of ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among TCGA patients. 

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