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Aromatherapy and Essential Oils (PDQ®)

Health Professional Version
Last Modified: 01/11/2012

Adverse Effects

Safety testing on essential oils has shown minimal adverse effects. Several oils have been approved for use as food additives and are classified as GRAS (generally recognized as safe) by the U.S. Food and Drug Administration; however, ingestion of large amounts of essential oils is not recommended. In addition, a few cases of contact dermatitis have been reported, mostly in aromatherapists who have had prolonged skin contact with oils in the context of aromatherapy massage.[1] Some essential oils (e.g., camphor oil) can cause local irritation; therefore, care should be taken when applying them. Phototoxicity has occurred when essential oils (particularly citrus oils) are applied directly to the skin before sun exposure. One case report also showed airborne contact dermatitis in the context of inhaled aromatherapy without massage.[2] Often, aromatherapy uses undefined mixtures of essential oils without specifying the plant sources. Allergic reactions are sometimes reported, especially following topical administration. As essential oils age, they are often oxidized so the chemical composition changes. Individual psychological associations with odors may result in adverse responses. Repeated exposure to lavender and tea tree oils by topical administration was shown in one study to be associated with reversible prepubertal gynecomastia.[3] The effects appear to have been caused by the purported weak estrogenic and antiandrogenic activities of lavender and tea tree oils. Therefore, avoiding these two essential oils is recommended in patients with estrogen -dependant tumors. However, this is the first published report of this type of adverse effect when using products containing tea tree or lavender oils.

References

  1. Bilsland D, Strong A: Allergic contact dermatitis from the essential oil of French marigold (Tagetes patula) in an aromatherapist. Contact Dermatitis 23 (1): 55-6, 1990.  [PUBMED Abstract]

  2. Schaller M, Korting HC: Allergic airborne contact dermatitis from essential oils used in aromatherapy. Clin Exp Dermatol 20 (2): 143-5, 1995.  [PUBMED Abstract]

  3. Henley DV, Lipson N, Korach KS, et al.: Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 356 (5): 479-85, 2007.  [PUBMED Abstract]





Glossary Terms

administration (ad-MIH-nih-STRAY-shun)
In medicine, the act of giving a treatment, such as a drug, to a patient. It can also refer to the way it is given, the dose, or how often it is given.
adverse effect (AD-vers eh-FEKT)
An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse effects do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe. Also called adverse event.
allergic response (uh-LER-jik reh-SPONTS)
A hypersensitive immune reaction to a substance that normally is harmless or would not cause an immune response in most people. An allergic response may cause harmful symptoms such as itching or inflammation or tissue injury.
aromatherapy (uh-ROH-muh-THAYR-uh-pee)
A type of complementary and alternative medicine that uses plant oils that give off strong pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.
aromatherapy massage (uh-ROH-muh-THAYR-uh-pee muh-SAZH)
A type of complementary and alternative medicine that uses rubbing and kneading of the skin with plant oils that give off strong, pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.
camphor (KAM-fer)
A substance that comes from the wood and bark of the camphor tree or is made in the laboratory. It has a very unique smell and taste and is used in commercial products (for example, mothballs). Camphor is used in topical anti-infective and anti-pruritic (anti-itching) agents.
case report (kays reh-PORT)
A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).
chemical (KEH-mih-kul)
A substance made up of elements, such as hydrogen or sodium.
dermatitis (DER-muh-TY-tis)
Inflammation of the skin.
essential oil (eh-SENT-shul oyl)
The scented liquid taken from certain plants using steam or pressure. Essential oils contain the natural chemicals that give the plant its “essence” (specific odor and flavor). Essential oils are used in perfumes, food flavorings, medicine, and aromatherapy.
estrogen (ES-truh-jin)
A type of hormone made by the body that helps develop and maintain female sex characteristics and the growth of long bones. Estrogens can also be made in the laboratory. They may be used as a type of birth control and to treat symptoms of menopause, menstrual disorders, osteoporosis, and other conditions.
Food and Drug Administration (... ad-MIH-nih-STRAY-shun)
An agency in the U.S. federal government whose mission is to protect public health by making sure that food, cosmetics, and nutritional supplements are safe to use and truthfully labeled. The Food and Drug Administration also makes sure that drugs, medical devices, and equipment are safe and effective, and that blood for transfusions and transplant tissue are safe. Also called FDA.
ingestion (in-JES-chun)
Taking into the body by mouth.
inhalation (IN-huh-LAY-shun)
In medicine, refers to the act of taking a substance into the body by breathing.
lavender (LA-ven-der)
A plant with aromatic leaves and flowers that is a member of the mint family. Oil from the flowers has been used in some cultures to treat certain medical problems, to keep insects away, and to wash in. It is also used in aromatherapy. Perillyl alcohol, a substance found in lavender, is being studied in cancer prevention and treatment. The scientific name is Lavandula angustifolia. Also called English lavender and true lavender.
odor (OH-der)
A smell.
phototoxicity (FOH-toh-tok-SIH-sih-tee)
A condition in which the skin or eyes become very sensitive to sunlight or other forms of light. It can be caused by taking certain drugs, or rubbing certain essential oils (scented liquid taken from plants) or other topical agents into the skin. Phototoxicity causes sunburn, blisters, and other skin problems.
psychological (SY-koh-LAH-jih-kul)
Having to do with how the mind works and how thoughts and feelings affect behavior.
response (reh-SPONTS)
In medicine, an improvement related to treatment.
tea tree (tee tree)
A tree that is a member of the myrtle family. Oil from the tea tree is used in shampoos and skin care products and to treat skin infections. It has been used in some cultures to treat other skin conditions, including acne, burns, and insect bites. The scientific name is Melaleuca alternifolia.
topical (TAH-pih-kul)
On the surface of the body.
tumor (TOO-mer)
An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm.