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Innovative Research in Cancer Nanotechnology (IRCNs)

The IRCNs address major barriers in cancer biology and oncology using nanotechnology approaches, and emphasize fundamental understanding of nanomaterial and nanodevice interactions with biological systems in vivo. The individual, circumscribed research projects are designed to enable multi-disciplinary team research and transformative discoveries in cancer biology and oncology, diagnostics, and therapeutics through the use of nanotechnology.

The outcomes of IRCN-supported projects are expected to better inform, inspire, and aid in the development of innovative, clinically relevant nanotechnology solutions for cancer through a greater understanding of these interaction mechanisms. To advance these nanotechnologies, the IRCN projects take advantage of the collaborative environment of the Alliance network.

  • UNIVERSITY OF CALIFORNIA LOS ANGELES – Covalent Chemistry on Nanosubstrates Enables Molecular Analysis of Purified Extracellular Vesicles in Hepatocellular Carcinoma
  • UNIVERSITY OF CALIFORNIA SAN DIEGO – Bioprinting Plant Virus Nanoparticles for Immunotherapy and Relapse Prevention of Ovarian Cancer
  • OHIO STATE UNIVERSITY – TNBC Ligand-displaying Exosomes Using RNA Nanotechnology for Targeted Cytosol Delivery of RNAi without Endosome Entrapment
  • BRIGHAM AND WOMEN'S HOSPITAL – Whitlockite nanoparticle-based immunotherapy for bone metastasis
  • STANFORD UNIVERSITY – Copper-depleting nanotheranostics for treating triple negative breast cancer
  • UNIVERSITY OF NEBRASKA MEDICAL CENTER – Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer
  • UNIVERSITY OF CALIFORNIA LOS ANGELES – Use of a Nano-Enabled Platform for Pancreatic Cancer Immunotherapy
  • UNIVERSITY OF NEBRASKA MEDICAL CENTER – Novel approach to attenuate small cell lung cancer growth and metastasis
  • STATE UNIVERSITY OF NEW YORK AT BUFFALO – A Cobalt Porphyrin Nanoliposome Adjuvant for MHC-I-Restricted Cancer Peptide Vaccines
  • UNIVERSITY OF CHICAGO – Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck Cancers
  • UNIV OF NORTH CAROLINA CHAPEL HILL – The development of novel radiation-sensitizer based on ultra-small carbon dots
  • UNIVERSITY OF CALIFORNIA AT DAVIS – HER2-targeting transformable nanotherapeutic platform against HER2+ cancers
  • CASE WESTERN RESERVE UNIVERSITY – Targeted immuno-nanoparticles for directing antitumor immune response against breast cancer metastasis
  • UNIVERSITY OF ALABAMA AT BIRMINGHAM – Nanodelivery platform for antibody drugs targeting non-Hodgkin lymphoma (NHL)
  • UNIVERSITY OF MARYLAND COLLEGE PARK – Nanotechnology for targeted therapy and fundamental understanding of therapeutic resistance in triple negative breast cancer
  • UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL WORCESTER – NanoOptogenetic immunotherapy for B cell lymphoma
  • BOSTON UNIVERSITY – Optimization of nanoparticle tumor-localization and drug-loading for treating Mesothelioma
  • NEW YORK UNIVERSITY – Map Leukemia-immune Cell Talks with Nanoplasmon Ruler in CAR T-Cell Immunotherapy
  • SLOAN-KETTERING INSTITUTE OF CANCER RESEARCH – Ultrasmall particle-based solutions for inducing ferroptosis and improving anti-tumor immune responses in cancer
  • JOHNS HOPKINS UNIVERSITY – The Tumor Microenvironment in Nanoparticle Delivery and Function