Familial Cancer Susceptibility Syndromes

Individual PDQ summaries focused on the genetics of specific cancers contain detailed information about many known cancer susceptibility syndromes. Although this is not a complete list, the following cancer susceptibility syndromes are discussed in the PDQ cancer genetics summaries:

• Basal Cell Nevus Syndrome, Gorlin Syndrome, Gorlin-Goltz Syndrome, or Nevoid Basal Cell Carcinoma Syndrome (Genetics of Skin Cancer ¹)
• Bloom Syndrome (Genetics of Skin Cancer ²)
• Breast/Ovarian Cancer, Hereditary (Genetics of Breast and Ovarian Cancer ³)
• Colon Cancer, Hereditary Nonpolyposis or Lynch Syndrome (Genetics of Colorectal Cancer ⁴)
• Cowden Syndrome (Genetics of Breast and Ovarian Cancer ⁵; Genetics of Colorectal Cancer ⁶)
• Fanconi Anemia (Genetics of Skin Cancer ⁷)
• Hyperparathyroidism, Familial (Genetics of Medullary Thyroid Cancer ⁸)
• Li-Fraumeni Syndrome (Genetics of Breast and Ovarian Cancer ⁹)
• Medullary Thyroid Cancer, Familial (Genetics of Medullary Thyroid Cancer ¹⁰)
• Melanoma, Hereditary (Genetics of Skin Cancer ¹¹)
• Multiple Endocrine Neoplasia Type 2A, 2B (Sipple Syndrome) (Genetics of Medullary Thyroid Cancer ¹²)
• Peutz-Jeghers Syndrome (Genetics of Colorectal Cancer ¹³; Genetics of Breast and Ovarian Cancer ¹⁴)
• Polyposis, Familial Adenomatous and Attenuated Familial Adenomatous Polyposis (Genetics of Colorectal Cancer ¹⁵)
• Polyposis, Familial Juvenile (Genetics of Colorectal Cancer ¹⁶)
• Polyposis, MYH-Associated (Genetics of Colorectal Cancer ¹⁷)
• Prostate Cancer, Hereditary (Genetics of Prostate Cancer ¹⁸)
• Xeroderma Pigmentosum (Genetics of Skin Cancer ¹⁹)