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Late Effects of Treatment for Childhood Cancer (PDQ®)
Patient VersionHealth Professional VersionEn españolLast Modified: 07/10/2007



General Information About Late Effects






Central Nervous System






Senses






Digestive System






Spleen






Heart






Lung






Kidney






Thyroid






Neuroendocrine System







Musculoskeletal System






Reproductive System






Second Cancers






Mortality






Long-Term Follow-Up






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Changes to This Summary (07/10/2007)






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Musculoskeletal System

Key Points for This Section


Bone

Childhood cancer survivors may have late effects that affect the bones.

Bone late effects may include the following:

  • Bone pain.
  • Joint stiffness.
  • Weak or thin bones that can break easily.
  • Decreased amounts of calcium in bones.
  • Decreased bone and tissue growth in treated areas.

Certain factors increase the risk that bone late effects will occur.

The following may increase the risk of bone late effects:

  • Being female.
  • Being older at the time of treatment.
  • Having low levels of estrogen or growth hormone.

Risk may also be increased in childhood cancer survivors who received either of the following:

Bone late effects may be caused by treatment for certain childhood cancers.

Treatment for these and other childhood cancers may cause bone late effects:

Body weight

Childhood cancer survivors may have late effects that affect body weight and cause obesity.

The following may increase the risk of obesity:

  • Being female and having received treatment at age 4 years or younger, with high- dose radiation therapy to the head.
  • Being young at the time of treatment (the younger the child, the greater the risk).
  • Being slender at the time of diagnosis.
  • Having an increase in body fat at an earlier than normal age.

Obesity may be caused by treatment for certain childhood cancers.

Treatment for these and other childhood cancers may cause obesity:

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