In English | En español
Questions About Cancer? 1-800-4-CANCER

Late Effects of Treatment for Childhood Cancer (PDQ®)

  • Last Modified: 08/22/2014

Page Options

  • Print This Page
  • Print This Document
  • View Entire Document
  • Email This Document

Urinary System



Kidney

Certain chemotherapy drugs increase the risk of kidney late effects.

The risk of health problems that affect the kidney increases after treatment with the following:

The following may also increase the risk of kidney late effects:

Late effects that affect the kidney may cause certain health problems.

Kidney late effects include the following:

Possible signs and symptoms of kidney late effects include changes in urination and swelling of the feet or hands.

These and other signs and symptoms may be caused by kidney late effects or by other conditions:

  • Feeling the need to urinate without being able to do so.
  • Frequent urination (especially at night).
  • Trouble urinating.
  • Feeling very tired.
  • Swelling of the legs, ankles, feet, face, or hands.
  • Itchy skin.
  • Nausea or vomiting.
  • A metal-like taste in the mouth or bad breath.
  • Headache.

Sometimes there are no symptoms in the early stages. Symptoms may appear as damage to the kidney continues over time. Talk to your child's doctor if your child has any of these problems.

Certain tests and procedures are used to detect (find) and diagnose health problems in the kidney.

These and other tests and procedures may be used to detect or diagnose kidney late effects:

  • Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.

  • Blood chemistry study : A procedure in which a blood sample is checked to measure the amounts of certain substances, such as magnesium, calcium, and potassium, released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance may be a sign of kidney disease.

  • Complete blood count (CBC): A procedure in which a sample of blood is drawn and checked for the following:

  • Urinalysis : A test to check the color of urine and its contents, such as sugar, protein, red blood cells, and white blood cells.

  • Twenty-four-hour urine test: A test in which urine is collected for 24 hours to measure the amounts of certain substances. An unusual (higher or lower than normal) amount of a substance, such as protein, urea nitrogen, or creatinine, can be a sign of disease in the organ or tissue that makes it.

  • Ultrasound exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs, such as the kidney, and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to be looked at later.

Talk to your child's doctor about whether your child needs to have tests and procedures to check for signs of kidney late effects. If tests are needed, find out how often they should be done.

Health habits that promote healthy kidneys are important for survivors of childhood cancer.

Childhood cancer survivors who had all or part of their kidney removed should talk to their doctor about the following:

  • Whether it is safe to play sports that have a high risk of heavy contact or impact such as football or hockey.
  • Bicycle safety and avoiding handlebar injuries.
  • Wearing a seatbelt around the hips, not the waist.

Bladder

Surgery to the pelvic area and certain chemotherapy drugs increase the risk of bladder late effects.

The risk of health problems that affect the bladder increases after treatment with the following:

  • Surgery to remove all or part of the bladder.
  • Surgery to the pelvis or brain.
  • Certain chemotherapy drugs, such as cyclophosphamide or ifosfamide.
  • Radiation therapy to areas near the bladder or urinary tract.

Late effects that affect the bladder may cause certain health problems.

Bladder late effects include the following:

Possible signs and symptoms of bladder late effects include changes in urination and swelling of the feet or hands.

These and other signs and symptoms may be caused by bladder late effects or by other conditions:

  • Feeling the need to urinate without being able to do so.
  • Frequent urination (especially at night).
  • Trouble urinating.
  • Feeling like the bladder does not empty completely after urination.
  • Swelling of the legs, ankles, feet, face, or hands.
  • Little or no bladder control.
  • Blood in the urine.

Talk to your child's doctor if your child has any of these problems.

Certain tests and procedures are used to detect (find) and diagnose health problems in the bladder.

These and other tests and procedures may be used to detect or diagnose bladder late effects:

  • Physical exam and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.

  • Blood chemistry study: A procedure in which a blood sample is checked to measure the amounts of certain substances, such as magnesium, calcium, and potassium, released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance may be a sign of bladder problems.

  • Urinalysis: A test to check the color of urine and its contents, such as sugar, protein, red blood cells, and white blood cells.

  • Ultrasound exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs, such as the kidney and bladder, and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to be looked at later.

Talk to your child's doctor about whether your child needs to have tests and procedures to check for signs of bladder late effects. If tests are needed, find out how often they should be done.