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Radiation Therapy, Paclitaxel, and Carboplatin with or without Trastuzumab in Treating Patients with Esophageal Cancer

Trial Status: Closed to Accrual and Intervention

This randomized phase III trial studies how well radiation therapy, paclitaxel, and carboplatin with or without trastuzumab work in treating patients with esophageal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as trastuzumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving radiation therapy and combination chemotherapy together with or without trastuzumab is more effective in treating esophageal cancer.

Inclusion Criteria

  • Pathologically confirmed primary adenocarcinoma of the esophagus that involves the mid (up to 25 cm), distal, or esophagogastric junction; the cancer may involve the stomach up to 5 cm
  • Endoscopy with biopsy
  • PRIOR TO STEP 1 REGISTRATION BUT WITHIN 56 DAYS PRIOR TO STEP 2 REGISTRATION
  • Intent to submit tissue for central HER2 testing
  • Stage T1N1-2, T2-3N0-2, according to the American Joint Committee on Cancer (AJCC) 7th edition staging, based on the following minimum diagnostic work-up: * Chest/abdominal/pelvic computed tomography (CT) or whole-body positron emission tomography (PET)/CT (NOTE: if CT is performed at this time point, whole-body PET/CT will be required prior to step 2 registration; PET/CT of skull base to mid-thigh is acceptable) (NOTE: if adenopathy is noted on CT or whole-body PET/CT scan, an endoscopic ultrasound is not required prior to STEP 2 registration as long as adequate tissue has been obtained for central HER2 testing) * Patients may have regional adenopathy including para-esophageal, gastric, gastrohepatic and celiac nodes; if celiac adenopathy is present, it must be =< 2 cm * Patients with tumors at the level of the carina or above must undergo bronchoscopy to exclude fistula
  • Zubrod performance status 0-2
  • Absolute neutrophil count (ANC) >= 1,500 cells/mm^3
  • Platelets >= 100,000 cells/mm^3
  • Hemoglobin >= 8.0 g/dL (note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dL is acceptable)
  • Creatinine =< 2 times upper limit of normal
  • Bilirubin =< 1.5 times upper limit of normal
  • Aspartate aminotransferase (AST) =< 3.0 times upper limit of normal
  • For women of childbearing potential, a negative serum or urine pregnancy test
  • Patients must sign a study-specific informed consent prior to study entry
  • CONDITIONS FOR PATIENT ELIGIBILITY PRIOR TO STEP 2 REGISTRATION (HER2-POSITIVE PATIENTS ONLY)
  • HER2 expressing adenocarcinoma of the esophagus centrally
  • Surgical consultation to confirm that patient will be able to undergo curative resection after completion of chemoradiation within 56 days prior to step 2 registration
  • Radiation oncology consultation to confirm that disease can be encompassed in a radiotherapy field within 56 days prior to step 2 registration
  • Consultation with a medical oncologist within 56 days prior to step 2 registration
  • Stage T1N1-2, T2-3N0-2, according to the AJCC 7th edition staging, based upon the following minimum diagnostic work-up: * History/physical examination, with documentation of the patient’s weight, within 14 days prior to step 2 registration * Whole-body PET/CT scan within 56 days prior to step 2 registration (if only CT performed prior to step 1 registration) * Endoscopic ultrasound within 56 days prior to step 2 registration, unless the patient is found to have adenopathy per CT or whole-body PET/CT scan * Electrocardiogram (EKG) within 56 days prior to step 2 registration * Serum creatinine =< 2 x the upper limit or normal within 14 days prior to step 2 registration
  • Zubrod performance status 0-2 within 14 days prior to step 2 registration
  • For women of childbearing potential, a negative serum pregnancy test within 14 days prior to step 2 registration
  • Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal by cardiac echocardiogram (echo) or multi gated acquisition (MUGA) scan within 56 days prior to step 2 registration
  • Women of childbearing potential and sexually active male participants must agree to practice adequate contraception while on study and for at least 60 days following the last dose of chemotherapy or trastuzumab

Exclusion Criteria

  • Patients with cervical esophageal carcinoma
  • Patients with T1N0 disease, T4 disease, and proximal esophageal cancers (15-24 cm)
  • Prior systemic chemotherapy for esophageal cancer; note that prior chemotherapy for a different cancer is allowable
  • Prior radiation therapy for esophageal cancer or prior chest radiotherapy
  • Prior anthracycline or taxane
  • Evidence of tracheoesophageal fistula or invasion into the trachea or major bronchi
  • Prior invasive malignancy (except non-melanomatous skin cancer), unless disease free for a minimum of 2 years (e.g., carcinoma in situ of the breast, oral cavity, or cervix are permissible)
  • Medical contraindications to esophagectomy
  • Prior therapy with any agent targeting the HER2 pathway or human epidermal growth factor receptor 1 (HER1) (epidermal growth factor receptor [EGFR]) pathway
  • Prior therapy with trastuzumab
  • Prior allergic reaction to the study drugs involved in this protocol or to a monoclonal antibody
  • Previous history of congestive heart failure
  • Severe, active comorbidity, defined as follows: * Unstable angina in the last 6 months * Transmural myocardial infarction within the last 6 months * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immunocompromised patients
  • Pregnant or nursing women or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception

Alabama

Birmingham
The Kirklin Clinic at Acton Road
Status: CLOSED_TO_ACCRUAL
Contact: Rojymon Jacob
Phone: 205-934-0309
University of Alabama at Birmingham Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Rojymon Jacob
Phone: 205-934-0309
Mobile
Providence Hospital
Status: COMPLETED
Contact: Thaddeus A. Beeker
Phone: 888-625-6896

Alaska

Anchorage
Alaska Breast Care and Surgery LLC
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Alaska Women's Cancer Care
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Anchorage Oncology Centre
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Katmai Oncology Group
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Providence Alaska Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412

Arizona

Phoenix
Mayo Clinic Hospital in Arizona
Status: COMPLETED
Contact: Michael G. Haddock
Phone: 507-538-7623
Scottsdale
Mayo Clinic in Arizona
Status: COMPLETED
Contact: Michael G. Haddock
Phone: 507-538-7623
Tucson
Banner University Medical Center - Tucson
Status: COMPLETED
Contact: Krisha J. Howell
Phone: 520-626-9008

California

Antioch
Kaiser Permanente-Deer Valley Medical Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Burlingame
Mills-Peninsula Medical Center
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Carmichael
Mercy San Juan Medical Center
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Castro Valley
East Bay Radiation Oncology Center
Status: COMPLETED
Contact: Jon M. Greif
Phone: 510-835-9900
Chico
Enloe Medical Center
Status: COMPLETED
Contact: Grace E. Yuh
Phone: 530-332-3808
Duarte
City of Hope Comprehensive Cancer Center
Status: COMPLETED
Contact: Joseph Chao
Phone: 800-826-4673
Dublin
Epic Care-Dublin
Status: COMPLETED
Contact: Jon M. Greif
Phone: 510-835-9900
Emeryville
Bay Area Breast Surgeons Inc
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Epic Care Partners in Cancer Care
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Fremont
Kaiser Permanente-Fremont
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Fresno
Fresno Cancer Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Kaiser Permanente-Fresno
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Greenbrae
Marin General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Lloyd T. Miyawaki
Phone: 415-925-7325
Los Angeles
Cedars Sinai Medical Center
Status: COMPLETED
Contact: Richard Tuli
Phone: 310-423-8965
Los Angeles County-USC Medical Center
Status: COMPLETED
Contact: Heinz-Josef Lenz
Phone: 323-865-0451
USC / Norris Comprehensive Cancer Center
Status: COMPLETED
Contact: Heinz-Josef Lenz
Phone: 323-865-0451
Martinez
Contra Costa Regional Medical Center
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Modesto
Kaiser Permanente-Modesto
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Memorial Medical Center
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Mountain View
El Camino Hospital
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Novato
Sutter Cancer Research Consortium
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Oakland
Alta Bates Summit Medical Center - Summit Campus
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Bay Area Tumor Institute
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Hematology and Oncology Associates-Oakland
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Highland General Hospital
Status: COMPLETED
Contact: Jon M. Greif
Phone: 510-835-9900
Kaiser Permanente Oakland-Broadway
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Kaiser Permanente-Oakland
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Orange
UC Irvine Health / Chao Family Comprehensive Cancer Center
Status: COMPLETED
Contact: Chaitali S. Nangia
Phone: 877-827-8839
Palo Alto
Palo Alto Medical Foundation Health Care
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Stanford Cancer Institute Palo Alto
Status: COMPLETED
Contact: Daniel T. Chang
Phone: 650-498-7061
Pleasanton
Valley Medical Oncology Consultants
Status: COMPLETED
Contact: James Henry Feusner
Phone: 510-450-7600
Rancho Cordova
Kaiser Permanente-Rancho Cordova Cancer Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Redwood City
Kaiser Permanente-Redwood City
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Richmond
Kaiser Permanente-Richmond
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Rohnert Park
Rohnert Park Cancer Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Roseville
Kaiser Permanente-Roseville
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
The Permanente Medical Group-Roseville Radiation Oncology
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Sacramento
Kaiser Permanente - Sacramento
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Kaiser Permanente-South Sacramento
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
South Sacramento Cancer Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Sutter Medical Center Sacramento
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
University of California Davis Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Arta Monir Monjazeb
Phone: 916-734-3089
Saint Helena
Saint Helena Hospital
Status: COMPLETED
Contact: David John Tate
Phone: 707-967-3698
San Francisco
California Pacific Medical Center-Pacific Campus
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Kaiser Permanente-San Francisco
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
San Jose
Kaiser Permanente-Santa Teresa-San Jose
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
San Leandro
Kaiser Permanente San Leandro
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
San Pablo
Doctors Medical Center- JC Robinson Regional Cancer Center
Status: COMPLETED
Contact: Jon M. Greif
Phone: 510-835-9900
San Rafael
Kaiser Permanente-San Rafael
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Santa Rosa
Kaiser Permanente-Santa Rosa
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
South San Francisco
Kaiser Permanente Cancer Treatment Center
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Kaiser Permanente-South San Francisco
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Stockton
Kaiser Permanente-Stockton
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Vacaville
Kaiser Permanente Medical Center-Vacaville
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Vallejo
Kaiser Permanente-Vallejo
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455
Sutter Solano Medical Center / Cancer Center
Status: COMPLETED
Contact: Christopher Uwe Jones
Phone: 415-209-2686
Walnut Creek
Kaiser Permanente-Walnut Creek
Status: COMPLETED
Contact: Samantha Andrews Seaward
Phone: 626-564-3455

Colorado

Aurora
Rocky Mountain Cancer Centers-Aurora
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
The Medical Center of Aurora
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Boulder
Boulder Community Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Boulder
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Colorado Springs
Penrose-Saint Francis Healthcare
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Penrose
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Denver
Colorado Blood Cancer Institute
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Porter Adventist Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Presbyterian - Saint Lukes Medical Center - Health One
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Midtown
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Rose
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rose Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
SCL Health Saint Joseph Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Western States Cancer Research NCORP
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 888-785-6789
Durango
Mercy Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Englewood
Mountain Blue Cancer Care Center - Swedish
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Swedish Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Fort Collins
Poudre Valley Hospital
Status: COMPLETED
Contact: Joshua Henry Petit
Phone: 970-482-3328
Golden
Mountain Blue Cancer Care Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Greeley
North Colorado Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Greenwood Village
Rocky Mountain Cancer Centers-Greenwood Village
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Saint Anthony Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Littleton
Littleton Adventist Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Littleton
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Sky Ridge Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Longmont
Longmont United Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Longmont
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Loveland
McKee Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Parker
Parker Adventist Hospital
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Rocky Mountain Cancer Centers-Parker
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Saint Mary Corwin Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Thornton
North Suburban Medical Center
Status: COMPLETED
Contact: Eduardo R. Pajon
Phone: 888-336-8262
Rocky Mountain Cancer Centers-Thornton
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789
Wheat Ridge
SCL Health Lutheran Medical Center
Status: COMPLETED
Contact: Keren Sturtz
Phone: 888-785-6789

Connecticut

Hartford
Hartford Hospital
Status: COMPLETED
Contact: Andrew L. Salner
Phone: 860-545-5363
Smilow Cancer Hospital Care Center at Saint Francis
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Meriden
Midstate Medical Center
Status: COMPLETED
Contact: Andrew L. Salner
Phone: 860-545-5363
Middletown
Middlesex Hospital
Status: COMPLETED
Contact: Susanna Hong
Phone: 860-358-2058
New Haven
Yale University
Status: COMPLETED
Contact: Kimberly Lauren Johung
Phone: 203-785-5702
Norwich
Eastern Connecticut Hematology and Oncology Associates
Status: COMPLETED
Contact: Dennis E. Slater
Phone: 860-886-8362
William Backus Hospital
Status: COMPLETED
Contact: Dennis E. Slater
Phone: 860-886-8362

Delaware

Newark
Christiana Care Health System-Christiana Hospital
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Christiana Gynecologic Oncology LLC
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Delaware Clinical and Laboratory Physicians PA
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Helen F Graham Cancer Center
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Medical Oncology Hematology Consultants PA
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Rehoboth Beach
Beebe Health Campus
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227
Wilmington
Christiana Care Health System-Wilmington Hospital
Status: COMPLETED
Contact: Adam Raben
Phone: 302-733-6227

Florida

Altamonte Springs
AdventHealth Altamonte
Status: CLOSED_TO_ACCRUAL
Contact: Robert James Sollaccio
Phone: 407-303-5623
Kissimmee
AdventHealth Kissimmee
Status: CLOSED_TO_ACCRUAL
Contact: Robert James Sollaccio
Phone: 407-303-5623
Miami
Miami Cancer Institute
Status: COMPLETED
Contact: Andre A. Abitbol
Phone: 800-599-2456
Orlando
AdventHealth East Orlando
Status: CLOSED_TO_ACCRUAL
Contact: Robert James Sollaccio
Phone: 407-303-5623
AdventHealth Orlando
Status: CLOSED_TO_ACCRUAL
Contact: Robert James Sollaccio
Phone: 407-303-5623
Stuart
Robert and Carol Weissman Cancer Center at Martin Health
Status: CLOSED_TO_ACCRUAL
Contact: Guillermo Abesada-Terk
Phone: 772-288-5858ext4
Winter Park
AdventHealth Winter Park
Status: CLOSED_TO_ACCRUAL
Contact: Robert James Sollaccio
Phone: 407-303-5623

Georgia

Atlanta
Emory University Hospital / Winship Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Jerome Carl Landry
Phone: 404-778-1868
Grady Health System
Status: CLOSED_TO_ACCRUAL
Contact: Jerome Carl Landry
Phone: 404-778-1868
Piedmont Hospital
Status: COMPLETED
Contact: Adam Wayne Nowlan
Phone: 404-425-7943
Fayetteville
Piedmont Fayette Hospital
Status: COMPLETED
Contact: Adam Wayne Nowlan
Phone: 404-425-7943
Gainesville
Northeast Georgia Medical Center-Gainesville
Status: COMPLETED
Contact: Frank Greer Lake
Phone: 770-219-8800
Macon
Medical Center of Central Georgia
Status: COMPLETED
Contact: Frederick M. Schnell
Phone: 478-633-1226
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: COMPLETED
Contact: John A. Pablo
Phone: 800-622-6877
Memorial Health University Medical Center
Status: COMPLETED
Contact: Aaron Watson Pederson
Phone: 912-350-8568

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Lewiston
Saint Joseph Regional Medical Center
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274

Illinois

Arlington Heights
Northwest Community Hospital
Status: COMPLETED
Contact: Stephen Schaeffer Nigh
Phone: 847-618-4968
Berwyn
Mac Neal Hospital
Status: COMPLETED
Contact: Keith L. Shulman
Phone: 773-564-5044
Carbondale
Memorial Hospital of Carbondale
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Centralia
Centralia Oncology Clinic
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Chicago
Northwestern University
Status: COMPLETED
Contact: John Patrick Hayes
Phone: 312-695-1301
University of Illinois
Status: COMPLETED
Contact: Neeta Kiran Venepalli
Phone: 312-355-3046
Weiss Memorial Hospital
Status: COMPLETED
Contact: Stuart A. Krauss
Phone: 773-564-5044
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Decatur Memorial Hospital
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Effingham
Crossroads Cancer Center
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Harvey
Ingalls Memorial Hospital
Status: COMPLETED
Contact: Sulochana D. Yalavarthi
Phone: 708-915-4673
Kankakee
Presence Saint Mary's Hospital
Status: COMPLETED
Contact: Sylvia Velinova Falls
Phone: 815-937-8780
Maywood
Loyola University Medical Center
Status: COMPLETED
Contact: William Small
Phone: 708-226-4357
Moline
Garneau, Stewart C MD (UIA Investigator)
Status: COMPLETED
Contact: David Martens Spector
Phone: 309-779-4200
Porubcin, Michael MD (UIA Investigator)
Status: COMPLETED
Contact: David Martens Spector
Phone: 309-779-4200
Spector, David MD (UIA Investigator)
Status: COMPLETED
Contact: David Martens Spector
Phone: 309-779-4200
Trinity Medical Center
Status: COMPLETED
Contact: David Martens Spector
Phone: 309-779-4200
Mount Vernon
Good Samaritan Regional Health Center
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Oak Lawn
Advocate Christ Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Amar Hamad
Phone: 800-323-8622
River Forest
West Suburban Medical Center
Status: COMPLETED
Contact: Keith L. Shulman
Phone: 773-564-5044
Rockford
SwedishAmerican Regional Cancer Center / ACT
Status: COMPLETED
Contact: Harvey E. Einhorn
Phone: 779-696-9400
Springfield
Memorial Medical Center
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740

Indiana

Beech Grove
Franciscan Saint Francis Health-Beech Grove
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Elkhart
Elkhart Clinic
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Elkhart General Hospital
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Michiana Hematology Oncology PC-Elkhart
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Fort Wayne
Parkview Hospital Randallia
Status: COMPLETED
Contact: Brian K. Chang
Phone: 260-373-8888
Radiation Oncology Associates PC
Status: COMPLETED
Contact: Brian K. Chang
Phone: 260-373-8888
Indianapolis
Franciscan Health Indianapolis
Status: COMPLETED
Contact: Stephen Eric Rubenstein
Phone: 317-851-2555
Kokomo
Community Howard Regional Health
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
La Porte
IU Health La Porte Hospital
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Saint Joseph Regional Medical Center-Mishawaka
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Muncie
IU Health Ball Memorial Hospital
Status: COMPLETED
Contact: Yunjie Xie Lin
Phone: 765-751-5850
Plymouth
Michiana Hematology Oncology PC-Plymouth
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Richmond
Reid Health
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
South Bend
Memorial Hospital of South Bend
Status: COMPLETED
Contact: David Alan Hornback
Phone: 800-284-7370
Michiana Hematology Oncology PC-South Bend
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Northern Indiana Cancer Research Consortium
Status: CLOSED_TO_ACCRUAL
Contact: Binh Nguyen Tran
Phone: 574-237-1328
South Bend Clinic
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Westville
Michiana Hematology Oncology PC-Westville
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328

Iowa

Ames
Mary Greeley Medical Center
Status: COMPLETED
Contact: Joseph James Merchant
Phone: 515-239-2621
McFarland Clinic PC - Ames
Status: COMPLETED
Contact: Joseph James Merchant
Phone: 515-239-2621
Bettendorf
Constantinou, Costas L MD (UIA Investigator)
Status: COMPLETED
Contact: David Martens Spector
Phone: 309-779-4200
Boone
McFarland Clinic PC-Boone
Status: COMPLETED
Contact: Joseph James Merchant
Phone: 515-239-2621
Cedar Rapids
Mercy Hospital
Status: COMPLETED
Contact: Deborah Weil Wilbur
Phone: 319-363-2690
Oncology Associates at Mercy Medical Center
Status: COMPLETED
Contact: Deborah Weil Wilbur
Phone: 319-363-2690
Clive
Mercy Cancer Center-West Lakes
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Des Moines
Iowa Methodist Medical Center
Status: COMPLETED
Contact: Robert J. Behrens
Phone: 515-282-2921
Iowa-Wide Oncology Research Coalition NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Deborah Weil Wilbur
Phone: 319-363-2690
Mercy Medical Center - Des Moines
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Iowa City
University of Iowa / Holden Comprehensive Cancer Center
Status: COMPLETED
Contact: Mark Charles Smith
Phone: 800-237-1225
Jefferson
McFarland Clinic PC-Jefferson
Status: COMPLETED
Contact: Joseph James Merchant
Phone: 515-239-2621
Marshalltown
McFarland Clinic PC-Marshalltown
Status: COMPLETED
Contact: Joseph James Merchant
Phone: 515-239-2621
Sioux City
Mercy Medical Center-Sioux City
Status: COMPLETED
Contact: Donald B. Wender
Phone: 712-252-0088
Saint Luke's Regional Medical Center
Status: COMPLETED
Contact: Donald B. Wender
Phone: 712-252-0088
Siouxland Regional Cancer Center
Status: COMPLETED
Contact: Donald B. Wender
Phone: 712-252-0088
West Des Moines
Mercy Medical Center-West Lakes
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119

Kansas

Kansas City
University of Kansas Cancer Center
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
University of Kansas Cancer Center-West
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
Overland Park
Menorah Medical Center
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
Saint Luke's South Hospital
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
University of Kansas Cancer Center-Overland Park
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
Prairie Village
Kansas City NCI Community Oncology Research Program
Status: CLOSED_TO_ACCRUAL
Contact: Rakesh Gaur
Phone: 816-932-2677
Salina
Salina Regional Health Center
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552

Kentucky

Crestview Hills
Oncology Hematology Care Inc-Crestview
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Lexington
Baptist Health Lexington
Status: COMPLETED
Contact: Marta S. Hayne
Phone: 859-260-6425
University of Kentucky / Markey Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Ronald Charles McGarry
Phone: 859-257-3379

Louisiana

New Orleans
Ochsner Medical Center Jefferson
Status: COMPLETED
Contact: Jyotsna Fuloria
Phone: 888-562-4763

Maine

Lewiston
Central Maine Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Daniel Cary Rausch
Phone: 207-795-8250
Portland
Maine Medical Center-Bramhall Campus
Status: COMPLETED
Contact: Ian Jared Bristol
Phone: 207-396-8090
Scarborough
Maine Medical Center- Scarborough Campus
Status: COMPLETED
Contact: Ian Jared Bristol
Phone: 207-396-8090

Maryland

Baltimore
Greater Baltimore Medical Center
Status: COMPLETED
Contact: Marshall A. Levine
Phone: 443-849-3706
University of Maryland / Greenebaum Cancer Center
Status: COMPLETED
Contact: Mohan Suntha
Phone: 800-888-8823
Bel Air
UM Upper Chesapeake Medical Center
Status: COMPLETED
Contact: Mohan Suntha
Phone: 800-888-8823
Salisbury
TidalHealth Peninsula Regional
Status: CLOSED_TO_ACCRUAL
Contact: John Romeo Mansueti
Phone: 866-922-6237

Massachusetts

Boston
Boston Medical Center
Status: COMPLETED
Contact: Lisa A. Kachnic
Phone: 617-638-8265
Brigham and Women's Hospital
Status: COMPLETED
Contact: Theodore Sunki Hong
Phone: 877-726-5130
Dana-Farber Cancer Institute
Status: COMPLETED
Contact: Theodore Sunki Hong
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center
Status: COMPLETED
Contact: Theodore Sunki Hong
Phone: 877-726-5130
Burlington
Lahey Hospital and Medical Center
Status: COMPLETED
Contact: Asa Joel Nixon
Phone: 781-744-8027
Milford
Dana-Farber / Brigham and Women's Cancer Center at Milford Regional
Status: COMPLETED
Contact: Theodore Sunki Hong
Phone: 877-726-5130
Pittsfield
Berkshire Medical Center - Cancer Center
Status: COMPLETED
Contact: Harvey Zimbler
Phone: 413-496-8205
South Weymouth
Dana-Farber / Brigham and Women's Cancer Center at South Shore
Status: COMPLETED
Contact: Theodore Sunki Hong
Phone: 877-726-5130
Springfield
Baystate Medical Center
Status: COMPLETED
Contact: Seth A. Kaufman
Phone: 413-794-9338
D'Amour Center for Cancer Care
Status: COMPLETED
Contact: Seth A. Kaufman
Phone: 413-794-9338

Michigan

Adrian
Bixby Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Hickman Cancer Center
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Ann Arbor
Michigan Cancer Research Consortium NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Samir Narayan
Phone: 734-712-4673
Saint Joseph Mercy Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
University of Michigan Comprehensive Cancer Center
Status: COMPLETED
Contact: James A. Hayman
Phone: 800-865-1125
Brownstown
Henry Ford Cancer Institute-Downriver
Status: COMPLETED
Contact: Eleanor M. Walker
Phone: 313-916-1784
Clinton Township
Henry Ford Macomb Hospital-Clinton Township
Status: COMPLETED
Contact: Eleanor M. Walker
Phone: 313-916-1784
Dearborn
Beaumont Hospital - Dearborn
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Detroit
Ascension Saint John Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Henry Ford Hospital
Status: COMPLETED
Contact: Eleanor M. Walker
Phone: 313-916-1784
Escanaba
Green Bay Oncology - Escanaba
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Flint
Genesys Hurley Cancer Institute
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Hurley Medical Center
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Iron Mountain
Green Bay Oncology - Iron Mountain
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Kalamazoo
Borgess Medical Center
Status: COMPLETED
Contact: Raymond Sterling Lord
Phone: 269-373-7458
Bronson Methodist Hospital
Status: COMPLETED
Contact: Raymond Sterling Lord
Phone: 269-373-7458
West Michigan Cancer Center
Status: COMPLETED
Contact: Sunil Nagpal
Phone: 269-373-7458
Lansing
Sparrow Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Livonia
Saint Mary Mercy Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Monroe
Mercy Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo Clinic Cancer Centers-Monroe
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Niles
Lakeland Hospital Niles
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Novi
Ascension Providence Hospitals - Novi
Status: COMPLETED
Contact: Michael J. Kraut
Phone: 248-849-5337
Pontiac
Saint Joseph Mercy Oakland
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Port Huron
Lake Huron Medical Center
Status: COMPLETED
Contact: Samir Narayan
Phone: 702-384-0013
Royal Oak
William Beaumont Hospital-Royal Oak
Status: COMPLETED
Contact: John M. Robertson
Phone: 248-551-7695
Saginaw
Ascension Saint Mary's Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
Saint Joseph
Lakeland Medical Center Saint Joseph
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Marie Yeager Cancer Center
Status: COMPLETED
Contact: Binh Nguyen Tran
Phone: 574-237-1328
Southfield
Ascension Providence Hospitals - Southfield
Status: COMPLETED
Contact: Michael J. Kraut
Phone: 248-849-5337
Troy
William Beaumont Hospital - Troy
Status: COMPLETED
Contact: John M. Robertson
Phone: 248-551-7695
Warren
Saint John Macomb-Oakland Hospital
Status: COMPLETED
Contact: Samir Narayan
Phone: 734-712-4673
West Bloomfield
Henry Ford West Bloomfield Hospital
Status: COMPLETED
Contact: Eleanor M. Walker
Phone: 313-916-1784

Minnesota

Burnsville
Fairview Ridges Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Coon Rapids
Mercy Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Duluth
Essentia Health Cancer Center
Status: COMPLETED
Contact: Bret E.B. Friday
Phone: 888-203-7267
Essentia Health Saint Mary's Medical Center
Status: COMPLETED
Contact: Bret E.B. Friday
Phone: 888-203-7267
Miller-Dwan Hospital
Status: COMPLETED
Contact: Bret E.B. Friday
Phone: 888-203-7267
Edina
Fairview Southdale Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Fridley
Unity Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Saint John's Hospital - Healtheast
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Minneapolis
Abbott-Northwestern Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Hennepin County Medical Center
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Robbinsdale
North Memorial Medical Health Center
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Rochester
Mayo Clinic in Rochester
Status: COMPLETED
Contact: Michael G. Haddock
Phone: 507-538-7623
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Status: COMPLETED
Contact: Vic Liengswangwong
Phone: 877-229-4907
Saint Louis Park
Metro Minnesota Community Oncology Research Consortium
Status: ADMINISTRATIVELY_COMPLETE
Contact: Paul W. Sperduto
Phone: 952-993-1517
Park Nicollet Clinic - Saint Louis Park
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Saint Paul
Regions Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
United Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Waconia
Ridgeview Medical Center
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Willmar
Rice Memorial Hospital
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517

Mississippi

Jackson
University of Mississippi Medical Center
Status: COMPLETED
Contact: Pierre Edouard De Delva
Phone: 601-815-6700
Pascagoula
Singing River Hospital
Status: COMPLETED
Contact: James E. Clarkson
Phone: 228-809-5292

Missouri

Bolivar
Central Care Cancer Center - Bolivar
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Bonne Terre
Parkland Health Center-Bonne Terre
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Branson
Cox Cancer Center Branson
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Cape Girardeau
Saint Francis Medical Center
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Southeast Cancer Center
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Chesterfield
Saint Luke's Hospital
Status: COMPLETED
Contact: Donald F. Busiek
Phone: 314-205-6936
Creve Coeur
Siteman Cancer Center at West County Hospital
Status: COMPLETED
Contact: Clifford G. Robinson
Phone: 800-600-3606
Independence
Centerpoint Medical Center LLC
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
Jefferson City
Capital Region Southwest Campus
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Joplin
Freeman Health System
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital Joplin
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Kansas City
Heartland Hematology and Oncology Associates Incorporated
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
North Kansas City Hospital
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
Research Medical Center
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
Saint Luke's Hospital of Kansas City
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
The University of Kansas Cancer Center-South
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
University of Kansas Cancer Center - North
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
Lee's Summit
Saint Luke's East - Lee's Summit
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
University of Kansas Cancer Center - Lee's Summit
Status: COMPLETED
Contact: Parvesh Kumar
Phone: 913-945-7552
Liberty
Liberty Radiation Oncology Center
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
Rolla
Delbert Day Cancer Institute at PCRMC
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Clinic-Rolla-Cancer and Hematology
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Saint Joseph
Heartland Regional Medical Center
Status: COMPLETED
Contact: Rakesh Gaur
Phone: 816-932-2677
Saint Louis
Mercy Hospital Saint Louis
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital South
Status: COMPLETED
Contact: Minxiang (Michael) Gu
Phone: 888-823-5923
Missouri Baptist Medical Center
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Saint Louis Cancer and Breast Institute-South City
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Saint Louis-Cape Girardeau CCOP
Status: CLOSED_TO_ACCRUAL
Contact: Bethany Graham Sleckman
Phone: 913-948-5588
Siteman Cancer Center-South County
Status: COMPLETED
Contact: Clifford G. Robinson
Phone: 800-600-3606
Washington University School of Medicine
Status: COMPLETED
Contact: Clifford G. Robinson
Phone: 800-600-3606
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Status: COMPLETED
Contact: Clifford G. Robinson
Phone: 800-600-3606
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Status: COMPLETED
Contact: Alan P. Lyss
Phone: 800-392-0936
Springfield
CoxHealth South Hospital
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital Springfield
Status: COMPLETED
Contact: Jay W. Carlson
Phone: 800-821-7532
Sullivan
Missouri Baptist Sullivan Hospital
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740
Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Status: COMPLETED
Contact: James Lloyd Wade
Phone: 217-876-4740

Montana

Billings
Billings Clinic Cancer Center
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Montana Cancer Consortium NCORP
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Saint Vincent Healthcare
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Bozeman
Bozeman Deaconess Hospital
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Butte
Saint James Community Hospital and Cancer Treatment Center
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Helena
Saint Peter's Community Hospital
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Kalispell
Kalispell Regional Medical Center
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Missoula
Saint Patrick Hospital - Community Hospital
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274

Nebraska

Grand Island
CHI Health Saint Francis
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Kearney
CHI Health Good Samaritan
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Omaha
Alegent Health Bergan Mercy Medical Center
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Alegent Health Lakeside Hospital
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Nebraska Methodist Hospital
Status: COMPLETED
Contact: Tien-Shew William Huang
Phone: 402-354-5144

Nevada

Henderson
21st Century Oncology-Henderson
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Henderson
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Henderson
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Henderson
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas
21st Century Oncology
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Fort Apache
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Vegas Tenaya
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer Therapy and Integrative Medicine
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Shadow
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Tenaya
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Central Valley
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Northwest
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Summerlin
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Centennial Hills
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Maryland Parkway
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-San Martin
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Tenaya
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Medical Center
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Nevada Cancer Research Foundation NCORP
Status: CLOSED_TO_ACCRUAL
Contact: John Allan Ellerton
Phone: 702-384-0013
OptumCare Cancer Care at Fort Apache
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Central
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Southeast
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Summerlin Hospital Medical Center
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada
Status: COMPLETED
Contact: John Allan Ellerton
Phone: 702-384-0013
Reno
Renown Regional Medical Center
Status: COMPLETED
Contact: Michael Chandler Hardacre
Phone: 702-384-0013

New Hampshire

Concord
Concord Hospital
Status: COMPLETED
Contact: Su Kyong Metcalfe
Phone: 800-441-1138
Dover
Wentworth-Douglass Hospital
Status: COMPLETED
Contact: Henry Leo Sonneborn
Phone: 603-740-2150
Lebanon
Dartmouth Hitchcock Medical Center
Status: COMPLETED
Contact: Bassem Isaac Zaki
Phone: 800-639-6918

New Jersey

Basking Ridge
Memorial Sloan Kettering Basking Ridge
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202
Camden
Cooper Hospital University Medical Center
Status: COMPLETED
Contact: Sucha Order Asbell
Phone: 856-325-6757
Morristown
Morristown Medical Center
Status: COMPLETED
Contact: Mona Karim
Phone: 973-971-5900
Mount Holly
Virtua Memorial
Status: COMPLETED
Contact: Lemuel S. Ariaratnam
Phone: 609-914-6762
Newark
Newark Beth Israel Medical Center
Status: COMPLETED
Contact: Charles S. Cathcart
Phone: 973-926-7230
Rutgers New Jersey Medical School
Status: COMPLETED
Contact: Sabin Bhagwan Motwani
Phone: 732-235-8675
Pennington
Capital Health Medical Center-Hopewell
Status: COMPLETED
Contact: Shirnett Karean Williamson
Phone: 800-255-3440
Sparta
Sparta Cancer Treatment Center
Status: COMPLETED
Contact: Voichita Bar Ad
Phone: 215-955-6084
Summit
Overlook Hospital
Status: COMPLETED
Contact: Mona Karim
Phone: 973-971-5900
Voorhees
MD Anderson Cancer Center at Cooper-Voorhees
Status: COMPLETED
Contact: Sucha Order Asbell
Phone: 856-325-6757
Virtua Voorhees
Status: COMPLETED
Contact: Lemuel S. Ariaratnam
Phone: 609-914-6762

New Mexico

Albuquerque
University of New Mexico Cancer Center
Status: COMPLETED
Contact: Fa-Chyi Lee
Phone: 505-272-6972

New York

Bronx
Montefiore Medical Center - Moses Campus
Status: COMPLETED
Contact: Lakshmi Rajdev
Phone: 718-904-2730
Montefiore Medical Center-Weiler Hospital
Status: COMPLETED
Contact: Lakshmi Rajdev
Phone: 718-904-2730
Canandiaqua
Sands Cancer Center
Status: COMPLETED
Contact: Yuhchyau Chen
Phone: 585-275-5830
Commack
Memorial Sloan Kettering Commack
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202
Glens Falls
Glens Falls Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Eric A. Pillemer
Phone: 518-926-6700
New York
Memorial Sloan Kettering Cancer Center
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202
Mount Sinai Union Square
Status: COMPLETED
Contact: Peter Sean Kozuch
Phone: 212-844-6286
Mount Sinai West
Status: COMPLETED
Contact: Peter Sean Kozuch
Phone: 212-844-6286
NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center
Status: COMPLETED
Contact: Naiyer Abbas Rizvi
Phone: 212-305-8615
Rochester
Highland Hospital
Status: COMPLETED
Contact: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester
Status: COMPLETED
Contact: Yuhchyau Chen
Phone: 585-275-5830
Wilmot Cancer Institute Radiation Oncology at Greece
Status: COMPLETED
Contact: Yuhchyau Chen
Phone: 585-275-5830
Sleepy Hollow
Memorial Sloan Kettering Sleepy Hollow
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202
Uniondale
Memorial Sloan Kettering Nassau
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202
West Harrison
Memorial Sloan Kettering Westchester
Status: COMPLETED
Contact: Abraham Jing-Ching Wu
Phone: 212-639-7202

North Carolina

Charlotte
Atrium Health Pineville / LCI-Pineville
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Cyrus Salo
Phone: 704-355-2884
Carolinas Medical Center / Levine Cancer Institute
Status: COMPLETED
Contact: Jonathan Cyrus Salo
Phone: 704-355-2884
Novant Health Presbyterian Medical Center
Status: COMPLETED
Contact: Justin Peter Favaro
Phone: 704-384-5369
Concord
Atrium Health Cabarrus / LCI-Concord
Status: COMPLETED
Contact: Jonathan Cyrus Salo
Phone: 704-355-2884
Kinston
Vidant Oncology-Kinston
Status: COMPLETED
Contact: Peter Robins Watson
Phone: 252-559-2200
Matthews
Matthews Radiation Oncology Center
Status: COMPLETED
Contact: Justin Peter Favaro
Phone: 704-384-5369
Monroe
Atrium Health Union / LCI-Union
Status: COMPLETED
Contact: Jonathan Cyrus Salo
Phone: 704-355-2884
Raleigh
Rex Cancer Center
Status: COMPLETED
Contact: Oludamilola Abidemi Olajide
Phone: 919-784-7209
Winston-Salem
Wake Forest University Health Sciences
Status: COMPLETED
Contact: Arthur William Blackstock
Phone: 336-713-6771

North Dakota

Fargo
Essentia Health Cancer Center-South University Clinic
Status: COMPLETED
Contact: Bret E.B. Friday
Phone: 888-203-7267
Minot
Trinity Cancer Care Center
Status: COMPLETED
Contact: Stephen N.C. Makoni
Phone: 800-862-0005

Ohio

Akron
Cleveland Clinic Akron General
Status: CLOSED_TO_ACCRUAL
Contact: Mitchel L. Fromm
Phone: 330-344-6348
Summa Health System - Akron Campus
Status: COMPLETED
Contact: Desiree E. Doncals
Phone: 330-375-6101
Barberton
Summa Health System - Barberton Campus
Status: COMPLETED
Contact: Desiree E. Doncals
Phone: 330-375-6101
Beachwood
UHHS-Chagrin Highlands Medical Center
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Belpre
Strecker Cancer Center-Belpre
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Bowling Green
Toledo Clinic Cancer Centers-Bowling Green
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Chardon
Geauga Hospital
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Chillicothe
Adena Regional Medical Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Cincinnati
Oncology Hematology Care Inc-Anderson
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Blue Ash
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Eden Park
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Kenwood
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Oncology Hematology Care Inc-Mercy West
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
University of Cincinnati Cancer Center-UC Medical Center
Status: COMPLETED
Contact: Kevin Patrick Redmond
Phone: 513-558-4553
Cleveland
Case Western Reserve University
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
MetroHealth Medical Center
Status: COMPLETED
Contact: Bruce J. Averbook
Phone: 216-778-8526
Columbus
Columbus NCI Community Oncology Research Program
Status: ADMINISTRATIVELY_COMPLETE
Contact: John Philip Kuebler
Phone: 614-566-3275
Columbus Oncology and Hematology Associates Inc
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Doctors Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Grant Medical Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Mount Carmel Health Center West
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Ohio State University Comprehensive Cancer Center
Status: COMPLETED
Contact: Evan John Wuthrick
Phone: 800-293-5066
Riverside Methodist Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
The Mark H Zangmeister Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Dayton
Dayton NCI Community Oncology Research Program
Status: ADMINISTRATIVELY_COMPLETE
Contact: Howard M. Gross
Phone: 937-775-1350
Good Samaritan Hospital - Dayton
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital North
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Delaware
Delaware Health Center-Grady Cancer Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Delaware Radiation Oncology
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Grady Memorial Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Elyria
Mercy Cancer Center-Elyria
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Fairfield
Oncology Hematology Care Inc-Healthplex
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Findlay
Blanchard Valley Hospital
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Franklin
Atrium Medical Center-Middletown Regional Hospital
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Greenville
Wayne Hospital
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Kettering
Kettering Medical Center
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Lancaster
Fairfield Medical Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Lancaster Radiation Oncology
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Lima
Lima Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Marietta
Marietta Memorial Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Maumee
Toledo Clinic Cancer Centers-Maumee
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Medina
Summa Health Medina Medical Center
Status: COMPLETED
Contact: Desiree E. Doncals
Phone: 330-375-6101
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Mount Vernon
Knox Community Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Newark
Licking Memorial Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Newark Radiation Oncology
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Oregon
Saint Charles Hospital
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo Clinic Cancer Centers-Oregon
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Parma
University Hospitals Parma Medical Center
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Portsmouth
Southern Ohio Medical Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Ravenna
University Hospitals Portage Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mitchel L. Fromm
Phone: 330-344-6348
Salem
UH Seidman Cancer Center at Salem Regional Medical Center
Status: COMPLETED
Contact: Desiree E. Doncals
Phone: 330-375-6101
Sandusky
North Coast Cancer Care
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
UH Seidman Cancer Center at Firelands Regional Medical Center
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Springfield
Springfield Regional Medical Center
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Sylvania
ProMedica Flower Hospital
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Tiffin
Mercy Hospital of Tiffin
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo
Mercy Health - Saint Anne Hospital
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Saint Vincent Mercy Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo Clinic Cancer Centers-Toledo
Status: COMPLETED
Contact: Rex B. Mowat
Phone: 800-444-3561
Toledo Community Hospital Oncology Program CCOP
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
University of Toledo
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Troy
Upper Valley Medical Center
Status: COMPLETED
Contact: Howard M. Gross
Phone: 937-775-1350
Wauseon
Fulton County Health Center
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
West Chester
University of Cincinnati Cancer Center-West Chester
Status: COMPLETED
Contact: Kevin Patrick Redmond
Phone: 513-558-4553
Westerville
Saint Ann's Hospital
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745
Westlake
UHHS-Westlake Medical Center
Status: COMPLETED
Contact: Jennifer Anne Dorth
Phone: 800-641-2422
Wooster
Cancer Treatment Center
Status: COMPLETED
Contact: Desiree E. Doncals
Phone: 330-375-6101
Zanesville
Genesis Healthcare System Cancer Care Center
Status: COMPLETED
Contact: John Philip Kuebler
Phone: 614-488-2745

Oklahoma

Oklahoma City
University of Oklahoma Health Sciences Center
Status: COMPLETED
Contact: Terence S. Herman
Phone: 405-271-4272
Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa
Status: COMPLETED
Contact: Terence S. Herman
Phone: 405-271-4272

Oregon

Clackamas
Clackamas Radiation Oncology Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Milwaukie
Providence Milwaukie Hospital
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Newberg
Providence Newberg Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Oregon City
Providence Willamette Falls Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Portland
Providence Portland Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Providence Saint Vincent Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Salem
Salem Hospital
Status: COMPLETED
Contact: John Strother
Phone: 503-561-2618

Pennsylvania

Beaver
UPMC-Heritage Valley Health System Beaver
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Bryn Mawr
Bryn Mawr Hospital
Status: COMPLETED
Contact: Albert S. DeNittis
Phone: 484-476-2649
Danville
Geisinger Medical Center
Status: COMPLETED
Contact: Thomas James Gergel
Phone: 570-271-5251
Drexel Hill
Delaware County Memorial Hospital
Status: COMPLETED
Contact: Rachelle M. Lanciano
Phone: 610-284-8237
Dunmore
Northeast Radiation Oncology Center
Status: COMPLETED
Contact: Voichita Bar Ad
Phone: 215-955-6084
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Johnstown
UPMC-Johnstown / John P. Murtha Regional Cancer Center
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
McKeesport
UPMC Cancer Center at UPMC McKeesport
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Moon Township
UPMC-Coraopolis / Heritage Valley Radiation Oncology
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Natrona Heights
Allegheny Valley Hospital
Status: COMPLETED
Contact: Moses Sundar Raj
Phone: 877-284-2000
UPMC Cancer Center-Natrona Heights
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
New Castle
UPMC Jameson
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Paoli
Paoli Memorial Hospital
Status: COMPLETED
Contact: Albert S. DeNittis
Phone: 484-476-2649
Philadelphia
American College of Radiology Imaging Network
Status: CLOSED_TO_ACCRUAL
Contact: Howard P Safran
Fox Chase Cancer Center
Status: COMPLETED
Contact: Joshua E. Meyer
Phone: 215-728-4790
Jefferson Torresdale Hospital
Status: COMPLETED
Contact: Voichita Bar Ad
Phone: 215-955-6084
Thomas Jefferson University Hospital
Status: COMPLETED
Contact: Voichita Bar Ad
Phone: 215-955-6084
Pittsburgh
Allegheny General Hospital
Status: COMPLETED
Contact: Moses Sundar Raj
Phone: 877-284-2000
UPMC Jefferson Regional Radiation Oncology
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
UPMC-Passavant Hospital
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
UPMC-Presbyterian Hospital
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
UPMC-Saint Clair Hospital Cancer Center
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
UPMC-Saint Margaret
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
UPMC-Shadyside Hospital
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Seneca
UPMC Cancer Center at UPMC Northwest
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
Washington
UPMC Washington Hospital Radiation Oncology
Status: COMPLETED
Contact: Dwight Earl Heron
Phone: 412-647-8073
West Reading
Reading Hospital
Status: COMPLETED
Contact: Michael L. Haas
Phone: 610-988-9323
Wexford
Wexford Health and Wellness Pavilion
Status: COMPLETED
Contact: Moses Sundar Raj
Phone: 877-284-2000
Wilkes-Barre
Geisinger Wyoming Valley / Henry Cancer Center
Status: COMPLETED
Contact: Thomas James Gergel
Phone: 570-271-5251
Wynnewood
Lankenau Medical Center
Status: COMPLETED
Contact: Albert S. DeNittis
Phone: 484-476-2649
Main Line Health NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Albert S. DeNittis
Phone: 866-225-5654

Rhode Island

Providence
Miriam Hospital
Status: COMPLETED
Contact: Howard P Safran
Phone: 401-444-1488
Radiation Oncology Associates Incorporated
Status: COMPLETED
Contact: Howard P Safran
Phone: 401-444-1488
Rhode Island Hospital
Status: COMPLETED
Contact: Howard P Safran
Phone: 401-444-1488

South Carolina

Anderson
AnMed Health Cancer Center
Status: COMPLETED
Contact: John Eric Doster
Phone: 864-512-1000
Boiling Springs
Prisma Health Cancer Institute - Spartanburg
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Charleston
Medical University of South Carolina
Status: COMPLETED
Contact: Steve H. Chin
Phone: 843-792-9321
Easley
Prisma Health Cancer Institute - Easley
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Greenville
Greenville Health System Cancer Institute-Andrews
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Prisma Health Cancer Institute - Butternut
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Prisma Health Cancer Institute - Eastside
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Prisma Health Cancer Institute - Faris
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Prisma Health Greenville Memorial Hospital
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Greer
Prisma Health Cancer Institute - Greer
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Rock Hill
Rock Hill Radiation Therapy Center
Status: COMPLETED
Contact: Jonathan Cyrus Salo
Phone: 704-355-2884
Seneca
Prisma Health Cancer Institute - Seneca
Status: COMPLETED
Contact: David Lawrence Grisell
Phone: 864-241-6251
Spartanburg
Spartanburg Medical Center
Status: COMPLETED
Contact: Patricia C. Griffin
Phone: 800-486-5941

Tennessee

Kingsport
Regional Cancer Center at Indian Path Community Hospital
Status: COMPLETED
Contact: Asheesh Shipstone
Phone: 423-578-8538
Wellmont Holston Valley Hospital and Medical Center
Status: COMPLETED
Contact: Asheesh Shipstone
Phone: 423-578-8538
Nashville
Vanderbilt University / Ingram Cancer Center
Status: COMPLETED
Contact: Anuradha Bapsi Chakravarthy
Phone: 800-811-8480

Texas

Dallas
UT Southwestern / Simmons Cancer Center-Dallas
Status: CLOSED_TO_ACCRUAL
Contact: Jeffrey John Meyer
Phone: 214-648-7097
Galveston
University of Texas Medical Branch
Status: COMPLETED
Contact: Todd Allen Swanson
Phone: 409-772-1950
Houston
Houston Methodist Hospital
Status: COMPLETED
Contact: Alexandria T. Phan
Phone: 713-790-2700
League City
UTMB Cancer Center at Victory Lakes
Status: COMPLETED
Contact: Todd Allen Swanson
Phone: 409-772-1950
Lubbock
Covenant Medical Center-Lakeside
Status: COMPLETED
Contact: Paul J. Anderson
Phone: 806-725-8000

Utah

American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Cedar City
Sandra L Maxwell Cancer Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Logan
Logan Regional Hospital
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Murray
Intermountain Medical Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Ogden
McKay-Dee Hospital Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Provo
Utah Valley Regional Medical Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Saint George
Dixie Medical Center Regional Cancer Center
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Salt Lake City
LDS Hospital
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Utah Cancer Specialists-Salt Lake City
Status: COMPLETED
Contact: R. Jeffrey Lee
Phone: 801-507-3950

Vermont

Saint Johnsbury
Norris Cotton Cancer Center-North
Status: COMPLETED
Contact: Bassem Isaac Zaki
Phone: 800-639-6918

Virginia

Danville
Danville Regional Medical Center
Status: COMPLETED
Contact: Peter J. Leider
Phone: 434-799-3753
Fredericksburg
Fredericksburg Oncology Inc
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
Norton
Southwest VA Regional Cancer Center
Status: COMPLETED
Contact: Asheesh Shipstone
Phone: 423-578-8538

Washington

Anacortes
Cancer Care Center at Island Hospital
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Auburn
MultiCare Auburn Medical Center
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Bellevue
Overlake Medical Center
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Bellingham
PeaceHealth Saint Joseph Medical Center
Status: COMPLETED
Contact: Michael Andre Taylor
Phone: 360-788-8223
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Harrison Medical Center
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Burien
Highline Medical Center-Main Campus
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Centralia
Providence Regional Cancer System-Centralia
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Everett
Providence Regional Cancer Partnership
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Federal Way
Saint Francis Hospital
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Issaquah
Swedish Cancer Institute-Issaquah
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Kennewick
Kadlec Clinic Hematology and Oncology
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Lacey
Providence Regional Cancer System-Lacey
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Lakewood
Saint Clare Hospital
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Longview
PeaceHealth Saint John Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Mount Vernon
Skagit Valley Hospital
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Olympia
Capital Medical Center
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Providence - Saint Peter Hospital
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Puyallup
MultiCare Good Samaritan Hospital
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Seattle
Fred Hutchinson Cancer Research Center
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Kaiser Permanente Washington
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Seattle Cancer Care Alliance
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Swedish Medical Center-First Hill
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
University of Washington Medical Center - Montlake
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Sequim
Olympic Medical Cancer Care Center
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Spokane
Cancer Care Northwest - Spokane South
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289
Evergreen Hematology and Oncology PS
Status: COMPLETED
Contact: Gary E. Goodman
Phone: 206-386-2323
Tacoma
MultiCare Allenmore Hospital
Status: COMPLETED
Contact: Yoshio Inoue
Phone: 888-823-5923
MultiCare Tacoma General Hospital
Status: COMPLETED
Contact: John A. Keech
Phone: 907-458-5380
Northwest Medical Specialties PLLC
Status: COMPLETED
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Northwest NCI Community Oncology Research Program
Status: ADMINISTRATIVELY_COMPLETE
Contact: Yoshio Inoue
Phone: 800-351-7955
Saint Joseph Medical Center
Status: COMPLETED
Contact: Yoshio Inoue
Phone: 888-823-5923
Vancouver
Compass Oncology Vancouver
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
PeaceHealth Southwest Medical Center
Status: COMPLETED
Contact: Matthew C. Solhjem
Phone: 503-215-6412
Wenatchee
Wenatchee Valley Hospital and Clinics
Status: COMPLETED
Contact: George E. Laramore
Phone: 206-616-8289

West Virginia

Charleston
West Virginia University Charleston Division
Status: COMPLETED
Contact: Steven James Jubelirer
Phone: 304-344-3457
Wheeling
Wheeling Hospital / Schiffler Cancer Center
Status: COMPLETED
Contact: Jondavid Pollock
Phone: 304-243-6442

Wisconsin

Burlington
Aurora Cancer Care-Southern Lakes VLCC
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Eau Claire
HSHS Sacred Heart Hospital
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Marshfield Clinic Cancer Center at Sacred Heart
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Germantown
Aurora Health Care Germantown Health Center
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Grafton
Aurora Cancer Care-Grafton
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Green Bay
Aurora BayCare Medical Center
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Green Bay Oncology Limited at Saint Mary's Hospital
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Green Bay Oncology at Saint Vincent Hospital
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Saint Vincent Hospital Cancer Center Green Bay
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Saint Vincent Hospital Cancer Center at Saint Mary's
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Kenosha
Aurora Cancer Care-Kenosha South
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
La Crosse
Gundersen Lutheran Medical Center
Status: COMPLETED
Contact: Collin D. Driscoll
Phone: 608-775-2385
Marinette
Aurora Bay Area Medical Group-Marinette
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Bay Area Medical Center
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Marshfield
Marshfield Medical Center
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Marshfield Medical Center-Marshfield
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Milwaukee
Aurora Cancer Care-Milwaukee
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Aurora Saint Luke's Medical Center
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Aurora Sinai Medical Center
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Medical College of Wisconsin
Status: COMPLETED
Contact: Candice Aitken Johnstone
Phone: 414-805-4380
Zablocki Veterans Administration Medical Center
Status: COMPLETED
Contact: Elizabeth M. Gore
Phone: 414-805-4380
Minocqua
Marshfield Clinic-Minocqua Center
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
New Richmond
Cancer Center of Western Wisconsin
Status: COMPLETED
Contact: Paul W. Sperduto
Phone: 952-993-1517
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Racine
Aurora Cancer Care-Racine
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Rhinelander
Ascension Saint Mary's Hospital
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Rice Lake
Marshfield Medical Center-Rice Lake
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Stevens Point
Ascension Saint Michael's Hospital
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Sturgeon Bay
Green Bay Oncology - Sturgeon Bay
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Status: COMPLETED
Contact: James L. Leenstra
Phone: 507-645-2655
Summit
Aurora Medical Center in Summit
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Waukesha
Aurora Cancer Care-Waukesha
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Wauwatosa
Aurora Cancer Care-Milwaukee West
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
West Allis
Aurora West Allis Medical Center
Status: COMPLETED
Contact: Ellen L. Ziaja
Phone: 800-252-2990
West Bend
Froedtert West Bend Hospital / Kraemer Cancer Center
Status: COMPLETED
Contact: Candice Aitken Johnstone
Phone: 414-805-4380
Weston
Diagnostic and Treatment Center
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400
Marshfield Medical Center - Weston
Status: COMPLETED
Contact: Rezwan Islam
Phone: 715-393-1400

Wyoming

Casper
Rocky Mountain Oncology
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Sheridan
Welch Cancer Center
Status: COMPLETED
Contact: Benjamin T. Marchello
Phone: 800-648-6274

PRIMARY OBJECTIVES:

l. To determine if trastuzumab increases disease-free survival when combined with trimodality treatment (radiation plus chemotherapy followed by surgery) for patients with human epidermal growth factor receptor 2 (HER2)-overexpressing esophageal adenocarcinoma.

SECONDARY OBJECTIVES:

I. To evaluate if the addition of trastuzumab to trimodality treatment increases the pathologic complete response rate and overall survival for patients with HER2-overexpressing esophageal adenocarcinoma.

II. To develop a tissue bank of tumor tissue from patients with non-metastatic esophageal adenocarcinoma.

III. To determine molecular correlates of complete pathologic response, disease-free survival, and overall survival for patients with HER2-overexpressing esophageal adenocarcinoma treated with neoadjuvant and maintenance trastuzumab.

IV. To evaluate predictors of cardiotoxicity in patients with esophageal cancer treated with trastuzumab and chemoradiation.

V. To evaluate adverse events associated with the addition of trastuzumab to trimodality treatment for patients with non-metastatic esophageal adenocarcinoma.

PATIENT-REPORTED QUALITY OF LIFE OBJECTIVES:

I. To determine if the addition of trastuzumab to trimodality treatment improves the patient-reported Functional Assessment of Cancer Therapy for Esophageal Cancer (FACT-E) Esophageal Cancer Subscale (ECS) score.

II. To determine if an improvement in the FACT-E ECS score at 6-8 weeks post completion of neoadjuvant chemoradiation correlates with pathologic complete response.

III. To determine if pathologic complete response correlates with the FACT-E ECS score at 1 year and/or 2 years from the start of chemoradiation.

IV. To determine if the addition of trastuzumab to trimodality treatment improves the Swallow Index and Eating Index Subscale scores of the FACT-E.

V. To determine if the addition of trastuzumab to paclitaxel, carboplatin, and radiation impacts quality-adjusted survival.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo radiotherapy once daily 5 days a week for 5.5 weeks. Patients also receive trastuzumab intravenously (IV) over 30-90 minutes on days 1, 8, 15, 22, 29, 36, and 57 and paclitaxel IV over 60 minutes and carboplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36. Beginning 21-56 days after surgery, patients receive trastuzumab IV over 30-90 minutes. Treatment repeats every 21 days for 13 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients undergo radiotherapy once daily 5 days a week for 5.5 weeks. Patients also receive paclitaxel IV over 60 minutes and carboplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36.

Within 5-8 weeks after completion of radiotherapy, all patients undergo surgery.

After completion of study therapy, patients are followed up every 4 months for 2 years and then yearly thereafter.

Trial Phase Phase III

Trial Type Treatment

Lead Organization
NRG Oncology

Principal Investigator
Howard P Safran

  • Primary ID RTOG-1010
  • Secondary IDs NCI-2011-02601, CDR0000683717
  • Clinicaltrials.gov ID NCT01196390