Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients with Prostate Cancer

Status: Active

Description

This randomized phase III trial studies androgen-deprivation therapy and radiation therapy in treating patients with prostate cancer. Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. Radiation therapy uses high-energy x-rays to kill tumor cells.

Eligibility Criteria

Inclusion Criteria

  • Pathologically (histologically or cytologically) proven diagnosis of prostatic adenocarcinoma within 180 days of registration at moderate- to high-risk for recurrence as determined by one of the following combinations: * Gleason score 7-10 + T1c-T2b (palpation) + prostate-specific antigen (PSA) < 50 ng/mL (includes intermediate- and high-risk patients) * Gleason score 6 + T2c-T4 (palpation) + PSA < 50 ng/mL OR Gleason score 6 + >= 50% (positive) biopsies + PSA < 50 ng/ml * Gleason score 6 + T1c-T2b (palpation) + PSA > 20 ng/mL * Patients previously diagnosed with low risk prostate cancer undergoing active surveillance who are re-biopsied and found to have unfavorable intermediate risk disease or favorable high risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure
  • History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration
  • Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal computed tomography [CT] or magnetic resonance [MR]), (but not by nodal sampling, or dissection) within 90 days prior to registration * Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are =< 1.5 cm
  • No evidence of bone metastases (M0) on bone scan within 120 days prior to registration (sodium fluoride [NaF] positron emission tomography [PET]/CT is an acceptable substitute) * Equivocal bone scan findings are allowed if plain films (or CT or magnetic resonance imaging [MRI]) are negative for metastasis
  • Baseline serum PSA value performed with a Food and Drug Administration (FDA)-approved assay (e.g., Abbott, Hybritech) within 120 days prior to registration
  • Study entry PSA should not be obtained during the following time frames: * 10-day period following prostate biopsy * Following initiation of hormonal therapy * Within 30 days after discontinuation of finasteride * Within 90 days after discontinuation of dutasteride
  • Zubrod performance status 0-1 (unless otherwise specified)
  • Within 60 days prior to registration on study: Absolute neutrophil count (ANC) >= 1,500/mm^3
  • Within 60 days prior to registration on study: Platelets >= 100,000/mm^3
  • Within 60 days prior to registration on study: Hemoglobin (Hgb) >= 8.0 g/dL (Note: the use of transfusion or other intervention to achieve Hgb >= 8.0 g/dL is acceptable)
  • Patient must be able to provide study specific informed consent prior to study entry

Exclusion Criteria

  • Prior invasive (except non-melanoma skin cancer) malignancy unless disease-free for a minimum of 3 years (1095 days) not in the pelvis (for example, carcinoma in situ of the oral cavity is permissible; however, patients with prior history of bladder cancer are not allowed); prior hematological (e.g., leukemia, lymphoma, myeloma) malignancy not allowed
  • Previous radical surgery (prostatectomy) or cryosurgery for prostate cancer
  • Previous pelvic irradiation, prostate brachytherapy, or bilateral orchiectomy
  • Previous hormonal therapy, such as LHRH agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate), estrogens (e.g., diethylstilbestrol [DES]), or surgical castration (orchiectomy)
  • Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both LHRH agonist and oral anti-androgen) is =< 45 days prior to the date of registration
  • Use of finasteride within 30 days prior to registration
  • Use of dutasteride or dutasteride/tamsulosin (Jalyn) within 90 days prior to registration
  • Previous or concurrent cytotoxic chemotherapy for prostate cancer; note that prior chemotherapy for a different cancer is allowable
  • Prior radiotherapy, including brachytherapy, to the region of the study cancer that would result in overlap of radiation therapy fields
  • Severe, active co-morbidity, defined as follows: * Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months * Transmural myocardial infarction within the last 6 months * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration * Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects or severe liver dysfunction * Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; protocol-specific requirements may also exclude immuno-compromised patients
  • Patients who are sexually active and not willing/able to use medically acceptable forms of contraception
  • Prior allergic reaction to the hormones involved in this protocol
  • Patients status post a negative lymph node dissection are not eligible

Locations & Contacts

Alabama

Mobile
University of South Alabama Mitchell Cancer Institute
Status: Active
Contact: Weisi Yan
Phone: 251-665-8000

Alaska

Anchorage
Alaska Oncology and Hematology LLC
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Fairbanks
Fairbanks Memorial Hospital
Status: Active
Contact: Huong Thanh Pham
Phone: 907-458-5380

Arizona

Gilbert
Arizona Breast Cancer Specialists-Gilbert
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 480-922-4600
Peoria
Arizona Center for Cancer Care-Peoria
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 623-773-2873
Phoenix
Arizona Breast Cancer Specialists-Phoenix
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 480-922-4600 Email: renee.schein@arizonaccc.com
Scottsdale
21st Century Oncology-Scottsdale
Status: Active
Contact: Frank A. Vicini
Phone: 480-945-6896
Arizona Breast Cancer Specialists
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 480-922-4600
Arizona Breast Cancer Specialists-Scottsdale
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 480-922-4600
Surprise
Arizona Center for Cancer Care-Surprise
Status: Active
Contact: Terry Tak-Keon Lee
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Tucson
Arizona Oncology Associates-West Orange Grove
Status: Active
Contact: Vivek S. Kavadi
Phone: 520-544-2919
The University of Arizona Medical Center-University Campus
Status: Active
Contact: Shona T. Dougherty
Phone: 520-626-9008

Arkansas

Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Little Rock
University of Arkansas for Medical Sciences
Status: Active
Contact: Sanjay Maraboyina
Phone: 501-686-8274

California

Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Bakersfield
AIS Cancer Center at San Joaquin Community Hospital
Status: Active
Contact: Richard K. Valicenti
Phone: 916-734-3089
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 818-708-5550 Email: Monica.Palacios@providence.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Carmichael
Mercy San Juan Medical Center
Status: Active
Contact: John M. Stevenson
Phone: 916-537-5237
Fresno
Fresno Cancer Center
Status: Active
Contact: Samantha Andrews Seaward
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Saint Agnes Medical Center
Status: Temporarily closed to accrual
Contact: Jedidiah Mercer Monson
Phone: 559-450-7790 Email: medresearch@samc.com
Greenbrae
Marin General Hospital
Status: Active
Name Not Available
Phone: 415-925-7325
La Jolla
UC San Diego Moores Cancer Center
Status: Active
Contact: Loren K. Mell
Phone: 858-822-5354 Email: cancercto@ucsd.edu
Long Beach
Veterans Administration Long Beach Medical Center
Status: Active
Contact: Steve Pai-Hsun Lee
Phone: 888-798-0719
Los Angeles
Cedars Sinai Medical Center
Status: Active
Contact: Howard M. Sandler
Phone: 310-423-8965
Los Angeles County-USC Medical Center
Status: Active
Contact: Leslie Ballas
Phone: 323-865-0451
USC / Norris Comprehensive Cancer Center
Status: Active
Contact: Leslie Ballas
Phone: 323-865-0451
Marysville
Fremont - Rideout Cancer Center
Status: Active
Contact: Richard K. Valicenti
Phone: 916-734-3089
Merced
Mercy UC Davis Cancer Center
Status: Active
Name Not Available
Phone: 209-564-3600
Modesto
Memorial Medical Center
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Oakland
Alta Bates Summit Medical Center - Summit Campus
Status: Temporarily closed to accrual
Contact: James Henry Feusner
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Kaiser Permanente Oakland-Broadway
Status: Active
Contact: Samantha Andrews Seaward
Phone: 510-891-3400
Palm Springs
Desert Regional Medical Center
Status: Active
Contact: Amir Lavaf
Phone: 760-416-4730
Palo Alto
Palo Alto Medical Foundation Health Care
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Paradise
Feather River Cancer Center
Status: Temporarily closed to accrual
Contact: Sam Mazj
Phone: 530-876-7995 Email: haleew@ah.org
Pomona
Pomona Valley Hospital Medical Center
Status: Active
Contact: Yallapragada S. (Ram) Rao
Phone: 909-865-9555
Rancho Cordova
Kaiser Permanente-Rancho Cordova Cancer Center
Status: Active
Contact: Samantha Andrews Seaward
Phone: 510-891-3400
Rohnert Park
Rohnert Park Cancer Center
Status: Active
Contact: Samantha Andrews Seaward
Phone: 707-584-2200
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
The Permanente Medical Group-Roseville Radiation Oncology
Status: Active
Contact: Samantha Andrews Seaward
Phone: 510-891-3400
Sacramento
Mercy Cancer Center - Sacramento
Status: Active
Contact: John M. Stevenson
Phone: 916-863-8731 Email: OncologyResearch@DignityHealth.org
South Sacramento Cancer Center
Status: Active
Contact: Samantha Andrews Seaward
Phone: 916-683-9616
Sutter Medical Center Sacramento
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
University of California Davis Comprehensive Cancer Center
Status: Active
Contact: Richard K. Valicenti
Phone: 916-734-3089
San Diego
University of California San Diego
Status: Active
Contact: Loren K. Mell
Phone: 858-822-5354 Email: cancercto@ucsd.edu
San Francisco
UCSF Medical Center-Mission Bay
Status: Active
Contact: Mack Roach
Phone: 877-827-3222
UCSF Medical Center-Mount Zion
Status: Active
Contact: Mack Roach
Phone: 877-827-3222
San Jose
Santa Clara Valley Medical Center
Status: Temporarily closed to accrual
Contact: Tri Minh Do
Phone: 888-823-5923 Email: ctsucontact@westat.com
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: Active
Contact: Samantha Andrews Seaward
Phone: 510-891-3400
South San Francisco
Kaiser Permanente Cancer Treatment Center
Status: Active
Contact: Samantha Andrews Seaward
Phone: 510-891-3400
Stockton
Saint Joseph's Medical Center
Status: Active
Contact: Gaurav Singh
Phone: 888-823-5923 Email: ctsucontact@westat.com
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Truckee
Gene Upshaw Memorial Tahoe Forest Cancer Center
Status: Active
Contact: Richard K. Valicenti
Phone: 916-734-3089
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: Active
Contact: Christopher Uwe Jones
Phone: 415-209-2686 Email: bernicl@sutterhealth.org

Colorado

Aurora
Rocky Mountain Cancer Centers-Aurora
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
University of Colorado Hospital
Status: Active
Contact: Brian Dennis Kavanagh
Phone: 720-848-0650
Boulder
Rocky Mountain Cancer Centers-Boulder
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Colorado Springs
UCHealth Memorial Hospital Central
Status: Active
Contact: Brian Dennis Kavanagh
Phone: 719-365-2406
Denver
Porter Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Edwards
The Shaw Regional Cancer Center
Status: Active
Contact: Patricia Harrigan Hardenbergh
Phone: 970-569-7429
Greeley
North Colorado Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Longmont
Longmont United Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Loveland
McKee Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Parker
Parker Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Connecticut

Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Status: Temporarily closed to accrual
Contact: Samir Narayan
Phone: 208-367-7954
Middletown
Middlesex Hospital
Status: Active
Contact: Susanna Hong
Phone: 860-358-2058 Email: beth_slifer@midhosp.org

Delaware

Newark
Christiana Care Health System-Christiana Hospital
Status: Active
Contact: Adam Raben
Phone: 302-733-6227
Helen F Graham Cancer Center
Status: Active
Contact: Adam Raben
Phone: 302-733-6227
Rehoboth Beach
Beebe Health Campus
Status: Active
Contact: Adam Raben
Phone: 302-733-6227
Seaford
Nanticoke Memorial Hospital
Status: Active
Contact: Adam Raben
Phone: 302-733-6227

District of Columbia

Washington
MedStar Washington Hospital Center
Status: Active
Contact: Pamela D. Randolph-Jackson
Phone: 202-877-8839

Florida

Jacksonville
Baptist MD Anderson Cancer Center
Status: Active
Contact: Michael Ray Olson
Phone: 904-202-7051
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: Active
Contact: Alan Libardi Dal Pra
Phone: 305-243-2647
Plantation
21st Century Oncology - Plantation
Status: Temporarily closed to accrual
Contact: Christopher Taigee Chen
Phone: 888-823-5923 Email: ctsucontact@westat.com
Tampa
James A. Haley Veterans Affairs Hospital
Status: Temporarily closed to accrual
Contact: Babu Zachariah
Phone: 888-716-7787
Weston
Cleveland Clinic-Weston
Status: Active
Contact: John Frank Greskovich
Phone: 954-659-5705

Georgia

Atlanta
Emory Saint Joseph's Hospital
Status: Active
Contact: Ashesh B. Jani
Phone: 404-489-9164
Emory University Hospital / Winship Cancer Institute
Status: Active
Contact: Ashesh B. Jani
Phone: 404-489-9164
Emory University Hospital Midtown
Status: Active
Contact: Ashesh B. Jani
Phone: 404-489-9164
Grady Health System
Status: Active
Contact: Ashesh B. Jani
Phone: 404-489-9164
Piedmont Hospital
Status: Active
Contact: Adam Wayne Nowlan
Phone: 404-425-7943 Email: ORS@piedmont.org
Columbus
John B Amos Cancer Center
Status: Active
Contact: Douglas F. Ciuba
Phone: 706-660-6404
Decatur
Atlanta VA Medical Center
Status: Active
Contact: Scott Edelman
Phone: 404-321-6111ext7632
Fayetteville
Piedmont Fayette Hospital
Status: Temporarily closed to accrual
Contact: Adam Wayne Nowlan
Phone: 404-425-7943 Email: ORS@piedmont.org
Macon
Central Georgia Gynecologic Oncology
Status: Temporarily closed to accrual
Contact: Frederick M. Schnell
Phone: 478-633-1226
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: Active
Contact: John A. Pablo
Phone: 912-819-5704

Hawaii

Aiea
The Cancer Center of Hawaii-Pali Momi
Status: Active
Contact: Richard Y. Lee
Phone: 808-678-9000
Honolulu
Queen's Medical Center
Status: Active
Contact: Richard Y. Lee
Phone: 412-339-5294 Email: Roster@nrgoncology.org
The Cancer Center of Hawaii-Liliha
Status: Active
Contact: Richard Y. Lee
Phone: 808-547-6011

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Coeur D'Alene
Kootenai Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Meridian
Idaho Urologic Institute-Meridian
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Post Falls
Kootenai Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Cancer Clinic
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Illinois

Arlington Heights
Northwest Community Hospital
Status: Active
Contact: Stephen Schaeffer Nigh
Phone: 847-618-4968
Aurora
Rush - Copley Medical Center
Status: Active
Contact: Sinisa Stanic
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Chicago
John H Stroger Jr Hospital of Cook County
Status: Active
Contact: Thomas E. Lad
Phone: 312-864-6000
Rush University Medical Center
Status: Active
Contact: Dian Wang
Phone: 312-942-5498 Email: clinical_trials@rush.edu
Weiss Memorial Hospital
Status: Active
Contact: Stuart A. Krauss
Phone: 773-564-5032
Decatur
Decatur Memorial Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Effingham
Crossroads Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Maywood
Loyola University Medical Center
Status: Active
Contact: Abhishek Ashok Solanki
Phone: 708-226-4357
Peoria
OSF Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Rockford
SwedishAmerican Regional Cancer Center / ACT
Status: Active
Contact: Harvey E. Einhorn
Phone: 779-696-9400 Email: cancercare@swedishamerican.org
Springfield
Memorial Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-788-3528
Saint John's Hospital
Status: Active
Contact: Samuel P. Au
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Swansea
Southwest Illinois Health Services LLP
Status: Active
Contact: Bryan A. Faller
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Urbana
Carle Cancer Center
Status: Active
Contact: Sinisa Stanic
Phone: 800-446-5532

Indiana

Fort Wayne
Parkview Hospital Randallia
Status: Active
Contact: Brian K. Chang
Phone: 260-373-8888 Email: parkviewresearch@parkview.com
Radiation Oncology Associates PC
Status: Temporarily closed to accrual
Name Not Available
Phone: 877-437-2408
Indianapolis
Indiana University / Melvin and Bren Simon Cancer Center
Status: Active
Contact: Timothy Lautenschlaeger
Phone: 412-339-5294 Email: Roster@nrgoncology.org
IU Health Methodist Hospital
Status: Active
Contact: Timothy Lautenschlaeger
Phone: 317-962-5731
South Bend
Memorial Hospital of South Bend
Status: Active
Contact: David Alan Hornback
Phone: 800-284-7370

Iowa

Ames
McFarland Clinic PC - Ames
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Cedar Rapids
Mercy Hospital
Status: Active
Contact: Deborah Weil Wilbur
Phone: 319-365-4673
Saint Luke's Hospital
Status: Active
Contact: Nagendra (Bobby) Sai Koneru
Phone: 800-397-2467
Dubuque
Finley Hospital
Status: Temporarily closed to accrual
Contact: Nagendra (Bobby) Sai Koneru
Phone: 800-397-2467

Kansas

Garden City
Central Care Cancer Center - Garden City
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Catherine Hospital
Status: Temporarily closed to accrual
Contact: Xinglei Shen
Phone: 800-592-5110 Email: info@cccancer.com
Kansas City
University of Kansas Cancer Center
Status: Active
Contact: Xinglei Shen
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Lawrence
Lawrence Memorial Hospital
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Olathe
Olathe Medical Center
Status: Active
Contact: Xinglei Shen
Phone: 913-791-3500 Email: Jeni.wakefield@olathehealth.org
Overland Park
University of Kansas Cancer Center-Overland Park
Status: Active
Contact: Xinglei Shen
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Topeka
Cotton O'Neil Cancer Center / Stormont Vail Health
Status: Active
Contact: David E. Einspahr
Phone: 888-823-5923 Email: ctsucontact@westat.com
Wichita
Via Christi Regional Medical Center
Status: Active
Contact: Shaker R. Dakhil
Phone: 800-362-0070

Kentucky

Lexington
University of Kentucky / Markey Cancer Center
Status: Temporarily closed to accrual
Contact: William H. St. Clair
Phone: 859-257-3379
Owensboro
Owensboro Health Mitchell Memorial Cancer Center
Status: Active
Contact: Ryan Jared Abel
Phone: 270-688-3691 Email: shawns@omhs.org

Louisiana

Baton Rouge
Mary Bird Perkins Cancer Center
Status: Active
Contact: Scott Edward Delacroix
Phone: 225-215-1353 Email: clinicalresearch@marybird.com
Covington
Mary Bird Cancer Center / Saint Tammany Parish
Status: Active
Contact: Scott Edward Delacroix
Phone: 225-215-1353 Email: clinicalresearch@marybird.com
Houma
Mary Bird Perkins Cancer Center / Terrebonne General Medical Center
Status: Active
Contact: Scott Edward Delacroix
Phone: 225-215-1353 Email: clinicalresearch@marybird.com
Metairie
East Jefferson General Hospital
Status: Active
Contact: Scott Edward Delacroix
Phone: 504-210-3539 Email: trials@jeffradonc.com
New Orleans
Ochsner Medical Center Jefferson
Status: Active
Contact: Troy Gene Scroggins
Phone: 504-842-3708
Touro Infirmary
Status: Active
Contact: Scott Edward Delacroix
Phone: 504-210-3539 Email: emede1@lsuhsc.edu
Tulane University Health Sciences Center
Status: Active
Contact: William Russell Robinson
Phone: 504-988-6121

Maryland

Annapolis
Anne Arundel Medical Center
Status: Active
Contact: Angel E. Torano
Phone: 443-481-1320 Email: kbodenhorn@aahs.org
Baltimore
Saint Agnes Hospital
Status: Active
Contact: Richard S. Hudes
Phone: 410-368-2910
University of Maryland / Greenebaum Cancer Center
Status: Active
Contact: Young Kwok
Phone: 800-888-8823
Bel Air
Upper Chesapeake Medical Center
Status: Active
Contact: Jack J. Hong
Phone: 443-643-3010
Columbia
Central Maryland Radiation Oncology in Howard County
Status: Active
Contact: Young Kwok
Phone: 443-546-1300
Elkton
University of Maryland Radiation Oncology Center at Union Hospital
Status: Active
Contact: Young Kwok
Phone: 410-328-7501 Email: sgrim@umm.edu
Glen Burnie
Tate Cancer Center
Status: Active
Contact: Young Kwok
Phone: 410-553-8100
Salisbury
Peninsula Regional Medical Center
Status: Active
Contact: John Romeo Mansueti
Phone: 866-922-6237

Massachusetts

Boston
Massachusetts General Hospital Cancer Center
Status: Temporarily closed to accrual
Contact: William Upjohn Shipley
Phone: 877-726-5130
Fall River
Saint Anne's Hospital
Status: Active
Contact: Michele Albert
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Lowell
Lowell General Hospital
Status: Active
Contact: Matthew Strauss Katz
Phone: 978-788-7084 Email: ghincks@lowellgeneral.org
Plymouth
Beth Israel Deaconess Hospital-Plymouth
Status: Active
Contact: James Matthew Koomey
Phone: 508-830-2390 Email: cancerinfo@jordanhospital.org

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
University of Michigan Comprehensive Cancer Center
Status: Active
Contact: Daniel Eidelberg Spratt
Phone: 800-865-1125
Veteran's Administration Medical Center - Ann Arbor
Status: Active
Contact: Dean A. Shumway
Phone: 800-865-1125
Battle Creek
Bronson Battle Creek
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Bay City
McLaren Cancer Institute-Bay City
Status: Active
Contact: Thomas P. Boike
Phone: 800-248-6777
Brownstown
Henry Ford Cancer Institute¿Downriver
Status: Active
Contact: Eleanor M. Walker
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Clarkston
21st Century Oncology MHP - Clarkston
Status: Active
Contact: Frank A. Vicini
Phone: 248-338-0663
McLaren Cancer Institute-Clarkston
Status: Active
Contact: Kiran Devisetty
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Clinton Township
Henry Ford Macomb Hospital-Clinton Township
Status: Active
Contact: Eleanor M. Walker
Phone: 313-916-1784
Dearborn
Beaumont Hospital-Dearborn
Status: Active
Contact: Daniel J. Krauss
Phone: 248-551-7695
Detroit
Henry Ford Hospital
Status: Active
Contact: Eleanor M. Walker
Phone: 313-916-1784
Saint John Hospital and Medical Center
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Wayne State University / Karmanos Cancer Institute
Status: Active
Contact: Kiran Devisetty
Phone: 313-576-9363
Farmington Hills
21st Century Oncology MHP - Farmington
Status: Active
Contact: Frank A. Vicini
Phone: 248-338-0663
Beaumont Hospital - Farmington Hills
Status: Active
Contact: Daniel J. Krauss
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Weisberg Cancer Treatment Center
Status: Active
Contact: Kiran Devisetty
Phone: 313-576-9363
Flint
McLaren Cancer Institute-Flint
Status: Active
Contact: Hesham El Gayar
Phone: 810-342-4071
Grand Rapids
Mercy Health Saint Mary's
Status: Active
Contact: Kathleen J. Yost
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Spectrum Health at Butterworth Campus
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Kalamazoo
West Michigan Cancer Center
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Lansing
McLaren-Greater Lansing
Status: Active
Contact: Kiran Devisetty
Phone: 517-334-2765
Sparrow Hospital
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Lapeer
McLaren Cancer Institute-Lapeer Region
Status: Active
Contact: Hesham El Gayar
Phone: 810-342-4071
Livonia
Saint Mary Mercy Hospital
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Mount Clemens
McLaren Cancer Institute-Macomb
Status: Active
Contact: Kiran Devisetty
Phone: 989-667-6257
Mount Pleasant
McLaren Cancer Institute-Central Michigan
Status: Active
Contact: Kiran Devisetty
Phone: 989-667-6257
Muskegon
Mercy Health Mercy Campus
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Owosso
McLaren Cancer Institute-Owosso
Status: Active
Contact: Hesham El Gayar
Phone: 810-342-4071
Petoskey
McLaren Cancer Institute-Northern Michigan
Status: Active
Contact: Thomas P. Boike
Phone: 800-248-6777
Pontiac
21st Century Oncology-Pontiac
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Saint Joseph Mercy Oakland
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Port Huron
McLaren-Port Huron
Status: Active
Contact: Kiran Devisetty
Phone: 313-576-9363
Royal Oak
William Beaumont Hospital-Royal Oak
Status: Active
Contact: Daniel J. Krauss
Phone: 248-551-7695
Saginaw
Saint Mary's of Michigan
Status: Active
Contact: Samir Narayan
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Saint Joseph
Lakeland Medical Center Saint Joseph
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Troy
21st Century Oncology MHP - Troy
Status: Active
Contact: Frank A. Vicini
Phone: 412-339-5294 Email: Roster@nrgoncology.org
William Beaumont Hospital - Troy
Status: Active
Contact: Daniel J. Krauss
Phone: 248-551-7695
Warren
Saint John Macomb-Oakland Hospital
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
West Bloomfield
Henry Ford West Bloomfield Hospital
Status: Active
Contact: Eleanor M. Walker
Phone: 888-734-5322

Minnesota

Albert Lea
Mayo Clinic Health System in Albert Lea
Status: Temporarily closed to accrual
Contact: Timothy F. Kozelsky
Phone: 855-776-0015
Bemidji
Sanford Clinic North-Bemidgi
Status: Active
Contact: Preston D. Steen
Phone: 218-333-5000
Duluth
Saint Luke's Hospital of Duluth
Status: Active
Contact: Steven R. Bonin
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Mankato
Mayo Clinic Health Systems-Mankato
Status: Temporarily closed to accrual
Contact: Ron S. Smith
Phone: 855-776-0015
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Status: Active
Contact: Donald James Jurgens
Phone: 877-229-4907 Email: coborncancercenter@centracare.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Status: Active
Contact: Paul W. Sperduto
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Status: Active
Contact: Paul W. Sperduto
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Status: Active
Contact: Paul W. Sperduto
Phone: 952-993-1517 Email: mmcorc@healthpartners.com

Mississippi

Jackson
University of Mississippi Medical Center
Status: Active
Contact: Srinivasan Vijayakumar
Phone: 601-815-6700
Pascagoula
Singing River Hospital
Status: Active
Contact: James E. Clarkson
Phone: 228-809-5292

Missouri

Cape Girardeau
Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-334-2230 Email: sfmc@sfmc.net
Southeast Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-651-5550
Creve Coeur
Siteman Cancer Center at West County Hospital
Status: Active
Contact: Jeff M. Michalski
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Joplin
Freeman Health System
Status: Active
Contact: Jay W. Carlson
Phone: 417-347-4030
Kansas City
Kansas City Veterans Affairs Medical Center
Status: Active
Contact: Eashwer K. Reddy
Phone: 800-525-1483
North Kansas City Hospital
Status: Active
Contact: Xinglei Shen
Phone: 816-691-1599
The University of Kansas Cancer Center-North
Status: Active
Contact: Xinglei Shen
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
The University of Kansas Cancer Center-South
Status: Active
Contact: Xinglei Shen
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Lee's Summit
The University of Kansas Cancer Center-Lee's Summit
Status: Active
Contact: Xinglei Shen
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Rolla
Delbert Day Cancer Institute at PCRMC
Status: Active
Contact: Jay W. Carlson
Phone: 573-202-9950 Email: jrichards@pcrmc.com
Saint Joseph
Heartland Regional Medical Center
Status: Active
Contact: Jay W. Carlson
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Louis
Mercy Hospital Saint Louis
Status: Active
Contact: Jay W. Carlson
Phone: 314-251-6770
Missouri Baptist Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Siteman Cancer Center-South County
Status: Temporarily closed to accrual
Contact: Jeff M. Michalski
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Washington University School of Medicine
Status: Active
Contact: Jeff M. Michalski
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Status: Active
Contact: Jeff M. Michalski
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Springfield
CoxHealth South Hospital
Status: Active
Contact: Jay W. Carlson
Phone: 800-821-7532

Montana

Billings
Billings Clinic Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 800-996-2663 Email: research@billingsclinic.org
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Nebraska

Omaha
Alegent Health Bergan Mercy Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
University of Nebraska Medical Center
Status: Active
Contact: Andrew Owen Wahl
Phone: 402-559-6941 Email: unmcrsa@unmc.edu

New Hampshire

Exeter
Exeter Hospital
Status: Active
Contact: Gary Miller Proulx
Phone: 800-439-3837
Lebanon
Dartmouth Hitchcock Medical Center
Status: Active
Contact: Alan Charles Hartford
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu

New Jersey

Mount Holly
Virtua Memorial
Status: Active
Contact: Lemuel S. Ariaratnam
Phone: 609-914-6762
Princeton
The Medical Center At Princeton
Status: Temporarily closed to accrual
Contact: Joseph M. Pepek
Phone: 609-497-4475
Somerville
Robert Wood Johnson University Hospital Somerset
Status: Active
Contact: Joel K. Braver
Phone: 908-685-2481
Sparta
Sparta Cancer Treatment Center
Status: Active
Contact: Robert Benjamin Den
Phone: 973-729-7001
Vineland
Inspira Medical Center Vineland
Status: Active
Contact: Joseph W. Fanelle
Phone: 856-641-7933
Voorhees
Virtua Voorhees
Status: Active
Contact: Lemuel S. Ariaratnam
Phone: 609-914-6762
Woodbury
Inspira Medical Center Woodbury
Status: Active
Contact: Joseph W. Fanelle
Phone: 412-339-5294 Email: Roster@nrgoncology.org

New Mexico

Las Cruces
Memorial Medical Center - Las Cruces
Status: Active
Contact: William M. Adler
Phone: 575-556-6545 Email: Kim.Hoffman@lpnt.net

New York

Bay Shore
Southside Hospital
Status: Temporarily closed to accrual
Contact: Louis Potters
Phone: 516-734-8896
Bronx
Bronx Veterans Administration Medical Center
Status: Active
Contact: Alice Van-Heng Cheuk
Phone: 718-584-9000 Email: kl2965@cumc.columbia.edu
Brooklyn
New York-Presbyterian / Brooklyn Methodist Hospital
Status: Active
Contact: Sameer Rafla-Demetrious
Phone: 718-780-3677 Email: Adg9003@nyp.org
Cooperstown
Mary Imogene Bassett Hospital
Status: Active
Contact: Timothy Paul Korytko
Phone: 607-547-3073 Email: diana.crean@bassett.org
Elmira
Arnot Ogden Medical Center / Falck Cancer Center
Status: Active
Contact: Chi K. Tsang
Phone: 607-271-7000
Lake Success
Northwell Health / Center for Advanced Medicine
Status: Temporarily closed to accrual
Contact: Louis Potters
Phone: 516-734-8896
New Hyde Park
Long Island Jewish Medical Center
Status: Temporarily closed to accrual
Contact: Louis Potters
Phone: 516-734-8896
New York
Columbia University / Herbert Irving Cancer Center
Status: Active
Contact: Israel Deutsch
Phone: 212-305-8615
Rochester
Highland Hospital
Status: Active
Contact: Yuhchyau Chen
Phone: 585-341-8113
University of Rochester
Status: Active
Contact: Yuhchyau Chen
Phone: 585-341-8113
Stony Brook
Stony Brook University Medical Center
Status: Active
Contact: Craig Eli Grossman
Phone: 800-862-2215

North Carolina

Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Status: Temporarily closed to accrual
Contact: Ronald C. Chen
Phone: 877-668-0683 Email: cancerclinicaltrials@med.unc.edu
Durham
Duke University Medical Center
Status: Temporarily closed to accrual
Name Not Available
Phone: 888-275-3853
Durham Veterans Affairs Medical Center
Status: Active
Contact: Joseph Kamel Salama
Phone: 919-286-6926 Email: John.Whited@va.gov
Morehead City
The Coleman Radiation Center-Carteret General Hospital
Status: Temporarily closed to accrual
Contact: Michael A. Papagikos
Phone: 252-808-6177
Supply
NHRMC Radiation Oncology - Supply
Status: Active
Contact: Michael A. Papagikos
Phone: 910-754-4716
Wilmington
NHRMC Radiation Oncology - 16th Street
Status: Active
Contact: Michael A. Papagikos
Phone: 910-251-1839
Winston-Salem
Novant Health Forsyth Medical Center
Status: Active
Contact: Judith Owen Hopkins
Phone: 336-277-8887
Wake Forest University Health Sciences
Status: Temporarily closed to accrual
Contact: Bart Alan Frizzell
Phone: 336-713-6771

North Dakota

Fargo
Sanford Broadway Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 800-437-4010

Ohio

Akron
Cleveland Clinic Akron General
Status: Active
Contact: Mitchel L. Fromm
Phone: 330-344-6348
Summa Akron City Hospital / Cooper Cancer Center
Status: Active
Contact: Desiree E. Doncals
Phone: 330-375-6101
Barberton
Summa Barberton Hospital
Status: Active
Contact: Desiree E. Doncals
Phone: 330-615-4132
Beachwood
UHHS-Chagrin Highlands Medical Center
Status: Active
Contact: Rodney J. Ellis
Phone: 216-844-1374
Canton
Mercy Medical Center
Status: Active
Contact: Edward J. Walsh
Phone: 888-293-4673
Chardon
Geauga Hospital
Status: Active
Contact: Rodney J. Ellis
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Chillicothe
Adena Regional Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 877-779-7585
Cleveland
Case Western Reserve University
Status: Active
Contact: Rodney J. Ellis
Phone: 800-641-2422
Cleveland Clinic Cancer Center / Fairview Hospital
Status: Active
Contact: Andrew D. Vassil
Phone: 216-476-9362
Cleveland Clinic Foundation
Status: Active
Contact: Andrew D. Vassil
Phone: 866-223-8100
Columbus
Mount Carmel Health Center West
Status: Active
Contact: Timothy David Moore
Phone: 614-234-5433
Ohio State University Comprehensive Cancer Center
Status: Active
Contact: Dayssy Alexandra Diaz Pardo
Phone: 800-293-5066 Email: Jamesline@osumc.edu
The Mark H Zangmeister Center
Status: Active
Contact: Timothy David Moore
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Elyria
Mercy Cancer Center-Elyria
Status: Active
Contact: Rodney J. Ellis
Phone: 800-641-2422 Email: CTUReferral@UHhospitals.org
Independence
Cleveland Clinic Cancer Center Independence
Status: Active
Contact: Andrew D. Vassil
Phone: 800-544-6333
Mansfield
Cleveland Clinic Cancer Center Mansfield
Status: Active
Contact: Andrew D. Vassil
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Maumee
Toledo Clinic Cancer Centers-Maumee
Status: Active
Contact: Rex B. Mowat
Phone: 888-823-5923 Email: ctsucontact@westat.com
Mayfield Heights
Hillcrest Hospital Cancer Center
Status: Active
Contact: Andrew D. Vassil
Phone: 440-312-4293 Email: hugneyc@cchseast.org
Medina
Summa Health Center at Lake Medina
Status: Active
Contact: Desiree E. Doncals
Phone: 330-375-4045
Mentor
Lake University Ireland Cancer Center
Status: Active
Contact: Rodney J. Ellis
Phone: 440-205-5491
Middleburg Heights
Southwest General Health Center Ireland Cancer Center
Status: Active
Contact: Rodney J. Ellis
Phone: 440-816-5050
Parma
University Hospitals Parma Medical Center
Status: Active
Contact: Rodney J. Ellis
Phone: 440-743-4747
Portsmouth
Southern Ohio Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Ravenna
University Hospitals Portage Medical Center
Status: Active
Name Not Available
Phone: 800-641-2422 Email: CTUReferral@UHhospitals.org
Salem
UH Seidman Cancer Center at Salem Regional Medical Center
Status: Temporarily closed to accrual
Contact: Desiree E. Doncals
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Sandusky
Ireland Cancer Center at Firelands Regional Medical Center
Status: Active
Contact: Rodney J. Ellis
Phone: 412-339-5294 Email: Roster@nrgoncology.org
North Coast Cancer Care
Status: Active
Contact: Andrew D. Vassil
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Strongsville
Cleveland Clinic Cancer Center Strongsville
Status: Active
Contact: Andrew D. Vassil
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Sylvania
Flower Hospital
Status: Active
Contact: Abhijit B. Saste
Phone: 419-824-1842
Toledo
Mercy Saint Anne Hospital
Status: Active
Contact: Rex B. Mowat
Phone: 419-407-1160
University of Toledo
Status: Active
Contact: Krishna Reddy
Phone: 419-383-6583
Westlake
UHHS-Westlake Medical Center
Status: Active
Contact: Rodney J. Ellis
Phone: 216-844-1374
Wooster
Cancer Treatment Center
Status: Temporarily closed to accrual
Contact: Desiree E. Doncals
Phone: 330-615-4132
Cleveland Clinic Wooster Family Health and Surgery Center
Status: Active
Contact: Andrew D. Vassil
Phone: 800-862-7798
Zanesville
Genesis Healthcare System Cancer Care Center
Status: Active
Contact: Timothy David Moore
Phone: 740-454-5232

Oklahoma

Oklahoma City
University of Oklahoma Health Sciences Center
Status: Temporarily closed to accrual
Contact: Terence S. Herman
Phone: 405-271-8777 Email: ou-clinical-trials@ouhsc.edu

Oregon

Clackamas
Clackamas Radiation Oncology Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Portland
Providence Portland Medical Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org

Pennsylvania

Abington
Abington Memorial Hospital
Status: Active
Name Not Available
Phone: 215-481-2402
Allentown
Lehigh Valley Hospital-Cedar Crest
Status: Active
Contact: Samir Narayan
Phone: 734-712-3671
Dunmore
Northeast Radiation Oncology Center
Status: Active
Contact: Robert Benjamin Den
Phone: 888-808-6762
Ephrata
Ephrata Cancer Center
Status: Active
Contact: Amit B. Shah
Phone: 717-721-4840
Furlong
Fox Chase Cancer Center Buckingham
Status: Active
Contact: Eric Mark Horwitz
Phone: 215-794-2700
Gettysburg
Adams Cancer Center
Status: Active
Contact: Amit B. Shah
Phone: 877-441-7957
Hanover
Cherry Tree Cancer Center
Status: Active
Contact: Amit B. Shah
Phone: 877-441-7957
Hershey
Penn State Milton S Hershey Medical Center
Status: Active
Contact: Henry Wagner
Phone: 717-531-3779 Email: CTO@hmc.psu.edu
Lebanon
Sechler Family Cancer Center
Status: Active
Contact: Amit B. Shah
Phone: 717-741-8303 Email: doxenberg@wellspan.org
Milford
Upper Delaware Valley Cancer Center
Status: Temporarily closed to accrual
Contact: Robert Benjamin Den
Phone: 866-549-8666
Philadelphia
Fox Chase Cancer Center
Status: Active
Contact: Eric Mark Horwitz
Phone: 215-728-4790
Pittsburgh
VA Pittsburgh Healthcare System
Status: Temporarily closed to accrual
Contact: Kristina Gerszten
Phone: 412-688-6104
West Reading
Reading Hospital
Status: Active
Contact: Michael L. Haas
Phone: 610-988-9323
York
WellSpan Health-York Hospital
Status: Active
Contact: Amit B. Shah
Phone: 877-441-7957

South Carolina

Anderson
AnMed Health Cancer Center
Status: Active
Contact: Leander III Cannick
Phone: 864-512-1000
Charleston
Medical University of South Carolina
Status: Active
Contact: David T. Marshall
Phone: 843-792-9321
Georgetown
Georgetown Hospital System
Status: Active
Contact: David T. Marshall
Phone: 843-545-5600
Greenville
Saint Francis Cancer Center
Status: Active
Contact: Jeremy M. Kilburn
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Greenwood
Self Regional Healthcare
Status: Active
Contact: David T. Marshall
Phone: 864-725-4771
Greer
Gibbs Cancer Center-Pelham
Status: Active
Contact: Patricia C. Griffin
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Hilton Head Island
The Radiation Oncology Center-Hilton Head / Bluffton
Status: Active
Contact: John A. Pablo
Phone: 912-819-5704
Spartanburg
Spartanburg Medical Center
Status: Active
Contact: Patricia C. Griffin
Phone: 800-486-5941

South Dakota

Sioux Falls
Sanford USD Medical Center - Sioux Falls
Status: Active
Contact: Preston D. Steen
Phone: 605-312-3320 Email: OncologyClinicalTrialsSF@SanfordHealth.org

Tennessee

Chattanooga
Erlanger Medical Center
Status: Temporarily closed to accrual
Contact: Donald Heaston Chamberlain
Phone: 888-823-5923 Email: ctsucontact@westat.com
Kingsport
Wellmont Holston Valley Hospital and Medical Center
Status: Active
Contact: Asheesh Shipstone
Phone: 423-224-5593
Nashville
Vanderbilt University / Ingram Cancer Center
Status: Active
Contact: Eric Tatsuo Shinohara
Phone: 800-811-8480

Texas

Abilene
Texas Cancer Center
Status: Active
Contact: Vivek S. Kavadi
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Dallas
UT Southwestern / Simmons Cancer Center-Dallas
Status: Active
Contact: Raquibul Hannan
Phone: 214-648-7097
Fort Sam Houston
Brooke Army Medical Center
Status: Active
Contact: Bronwyn Ruddy Stall
Phone: 210-916-4837
Fort Worth
The Klabzuba Cancer Center
Status: Active
Contact: Vivek S. Kavadi
Phone: 817-820-4700
Galveston
University of Texas Medical Branch
Status: Active
Contact: Martin Colman
Phone: 409-772-1950 Email: clinical.research@utmb.edu
League City
UTMB Cancer Center at Victory Lakes
Status: Active
Contact: Martin Colman
Phone: 409-772-1950 Email: clinical.research@utmb.edu
McAllen
Texas Oncology-McAllen
Status: Active
Contact: Vivek S. Kavadi
Phone: 412-339-5294 Email: Roster@nrgoncology.org
McKinney
Texas Oncology-McKinney
Status: Active
Contact: Vivek S. Kavadi
Phone: 972-542-8609
Plano
Texas Oncology-Plano West
Status: Active
Contact: Vivek S. Kavadi
Phone: 412-339-5294 Email: Roster@nrgoncology.org
San Antonio
University of Texas Health Science Center at San Antonio
Status: Active
Contact: Chul Soo Ha
Phone: 210-450-3800 Email: CTO@uthscsa.edu
Sherman
Texas Cancer Center-Sherman
Status: Active
Contact: Vivek S. Kavadi
Phone: 903-868-4700
Sugar Land
Texas Oncology Cancer Center Sugar Land
Status: Active
Contact: Vivek S. Kavadi
Phone: 281-277-5200
Webster
Deke Slayton Cancer Center
Status: Active
Contact: Vivek S. Kavadi
Phone: 412-339-5294 Email: Roster@nrgoncology.org

Utah

American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Status: Active
Contact: R. Jeffrey Lee
Phone: 801-855-4100
Murray
Intermountain Medical Center
Status: Active
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Ogden
Ogden Regional Medical Center
Status: Active
Contact: Brandon J. Fisher
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Provo
Utah Valley Regional Medical Center
Status: Active
Contact: R. Jeffrey Lee
Phone: 801-357-7965
Saint George
Dixie Medical Center Regional Cancer Center
Status: Active
Contact: R. Jeffrey Lee
Phone: 435-688-4167
Salt Lake City
Huntsman Cancer Institute / University of Utah
Status: Active
Contact: Jonathan D. Tward
Phone: 801-581-4477 Email: clinical.trials@hci.utah.edu
Utah Cancer Specialists-Salt Lake City
Status: Active
Contact: R. Jeffrey Lee
Phone: 801-933-6070 Email: research@utahcancer.com

Vermont

Bennington
Southwestern Vermont Medical Center
Status: Active
Contact: Alan Charles Hartford
Phone: 802-447-1836
Berlin
Central Vermont Medical Center / National Life Cancer Treatment
Status: Active
Contact: Harold James Wallace
Phone: 802-225-5400
Burlington
University of Vermont Medical Center
Status: Active
Contact: Harold James Wallace
Phone: 802-656-4101
Saint Johnsbury
Norris Cotton Cancer Center-North
Status: Active
Contact: Alan Charles Hartford
Phone: 802-473-4100

Virginia

Charlottesville
University of Virginia Cancer Center
Status: Active
Contact: Timothy Norman Showalter
Phone: 434-243-6322 Email: JME3D@hscmail.mcc.virginia.edu
Fishersville
Augusta Health Cancer Center
Status: Active
Contact: Robert M. Kyler
Phone: 540-245-7106
Hampton
Sentara Cancer Institute at Sentara CarePlex Hospital
Status: Active
Contact: Mark E. Shaves
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Harrisonburg
Sentara Rockingham Memorial Hospital Hahn Cancer Center
Status: Temporarily closed to accrual
Name Not Available
Phone: 540-689-7000
Norfolk
Bon Secours DePaul Medical Center
Status: Active
Contact: William Johnson Irvin
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Sentara Norfolk General Hospital
Status: Active
Contact: Mark E. Shaves
Phone: 757-388-2406
Portsmouth
Naval Medical Center - Portsmouth
Status: Active
Contact: Andrew S. Camarata
Phone: 757-953-5939
Richmond
Hunter Holmes McGuire Veterans Administration Medical Center
Status: Active
Contact: Drew Moghanaki
Phone: 804-675-5646 Email: Regina.McClung@va.gov
Roanoke
Oncology and Hematology Associates of Southwest Virginia
Status: Active
Contact: Vivek S. Kavadi
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Suffolk
Sentara Obici Hospital
Status: Active
Contact: Mark E. Shaves
Phone: 757-388-5109 Email: djoverto@sentara.com
Virginia Beach
Sentara Virginia Beach General Hospital
Status: Active
Contact: Mark E. Shaves
Phone: 412-339-5294 Email: Roster@nrgoncology.org

Washington

Federal Way
Saint Francis Hospital
Status: Active
Contact: Huong Thanh Pham
Phone: 253-944-8100
Seattle
Virginia Mason Medical Center
Status: Active
Contact: Huong Thanh Pham
Phone: 206-342-6954 Email: vmmc.cancer_clinical_research@VirginiaMason.org
Tacoma
Madigan Army Medical Center
Status: Active
Contact: Timothy Charles Brand
Phone: 253-968-0129 Email: mamcdci@amedd.army.mil
Vancouver
PeaceHealth Southwest Medical Center
Status: Active
Contact: Benjamin Buckner Bridges
Phone: 360-514-3940 Email: kmakin-bond@peacehealth.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Status: Temporarily closed to accrual
Contact: Matthew C. Solhjem
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org

West Virginia

Bridgeport
United Hospital Center
Status: Active
Contact: Malcolm David Mattes
Phone: 304-293-7374 Email: cancertrialsinfo@hsc.wvu.edu
Morgantown
West Virginia University Healthcare
Status: Active
Contact: Malcolm David Mattes
Phone: 304-293-7374 Email: cancertrialsinfo@hsc.wvu.edu

Wisconsin

Antigo
Langlade Hospital and Cancer Center
Status: Active
Contact: Christopher S. Platta
Phone: 715-623-9869 Email: Juli.Alford@aspirus.org
Appleton
Radiology Associates of Appleton / ThedaCare Regional Medical Center
Status: Active
Contact: Michael Edward Ray
Phone: 920-380-1500
ThedaCare Regional Cancer Center
Status: Active
Contact: Michael Edward Ray
Phone: 844-510-3600
Brookfield
Wheaton Franciscan Healthcare-Elmbrook Memorial Hospital
Status: Active
Contact: James H. Taylor
Phone: 262-785-2273
Eau Claire
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Status: Temporarily closed to accrual
Contact: Sakti Chakrabarti
Phone: 855-776-0015
Franklin
Wheaton Franciscan Healthcare-Saint Francis / Reiman Cancer Center
Status: Active
Contact: James H. Taylor
Phone: 262-785-2273
Green Bay
Aurora BayCare Medical Center
Status: Active
Contact: Ellen L. Ziaja
Phone: 414-649-5717
Saint Vincent Hospital Cancer Center at Saint Mary's
Status: Active
Contact: Eva N. Christensen
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Saint Vincent Hospital Cancer Center Green Bay
Status: Active
Contact: Eva N. Christensen
Phone: 920-433-8889 Email: Christy.Gilchrist@hshs.org
Johnson Creek
UW Cancer Center Johnson Creek
Status: Active
Name Not Available
Phone: 920-699-3500 Email: lynda.persico@uwmf.wisc.edu
La Crosse
Gundersen Lutheran Medical Center
Status: Active
Contact: Collin D. Driscoll
Phone: 608-775-2385 Email: cancerctr@gundersenhealth.org
Mayo Clinic Health System-Franciscan Healthcare
Status: Temporarily closed to accrual
Contact: David J. Schwartz
Phone: 855-776-0015
Madison
University of Wisconsin Hospital and Clinics
Status: Active
Name Not Available
Phone: 800-622-8922
Marinette
Aurora Bay Area Medical Group-Marinette
Status: Active
Contact: Ellen L. Ziaja
Phone: 414-302-2304 Email: ncorp@aurora.org
Menomonee Falls
Community Memorial Hospital
Status: Active
Contact: Colleen A. F. Lawton
Phone: 262-257-5100
Mequon
Columbia Saint Mary's Hospital - Ozaukee
Status: Active
Contact: Craig Allan Schulz
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Milwaukee
Aurora Saint Luke's Medical Center
Status: Active
Contact: Ellen L. Ziaja
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Columbia Saint Mary's Water Tower Medical Commons
Status: Active
Contact: Craig Allan Schulz
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Froedtert and the Medical College of Wisconsin
Status: Active
Contact: Colleen A. F. Lawton
Phone: 414-805-4380
Wheaton Franciscan Healthcare - Saint Joseph
Status: Active
Contact: James H. Taylor
Phone: 262-785-2273
Zablocki Veterans Administration Medical Center
Status: Active
Contact: Elizabeth M. Gore
Phone: 888-469-6614
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Status: Active
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Racine
Wheaton Franciscan Cancer Care - All Saints
Status: Active
Contact: James H. Taylor
Phone: 262-785-2273
Sheboygan
HSHS Saint Nicholas Hospital
Status: Active
Contact: Eva N. Christensen
Phone: 920-433-8889 Email: Christy.Gilchrist@hshs.org
Vince Lombardi Cancer Clinic-Sheboygan
Status: Active
Contact: Ellen L. Ziaja
Phone: 414-649-7200
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Status: Active
Contact: Eva N. Christensen
Phone: 920-433-8889 Email: Christy.Gilchrist@hshs.org
Summit
Aurora Medical Center in Summit
Status: Active
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Status: Active
Contact: Ellen L. Ziaja
Phone: 800-252-2990
Wausau
Aspirus Regional Cancer Center
Status: Active
Contact: Christopher S. Platta
Phone: 877-405-6866
West Allis
Aurora West Allis Medical Center
Status: Active
Contact: Ellen L. Ziaja
Phone: 414-328-6000
West Bend
The Alyce and Elmore Kraemer Cancer Care Center
Status: Active
Contact: Colleen A. F. Lawton
Phone: 866-680-0505
Wisconsin Rapids
Aspirus UW Cancer Center
Status: Active
Name Not Available
Phone: 715-422-7718

Wyoming

Cody
Billings Clinic-Cody
Status: Active
Contact: Benjamin T. Marchello
Phone: 800-996-2663 Email: research@billingsclinic.org

Alberta

Calgary
Tom Baker Cancer Centre
Status: Active
Contact: Alexander G. Balogh
Phone: 403-521-3433
Edmonton
Cross Cancer Institute
Status: Temporarily closed to accrual
Contact: Brita Lavender Danielson
Phone: 780-432-8500

British Columbia

Kelowna
BCCA-Cancer Centre for the Southern Interior
Status: Temporarily closed to accrual
Contact: Juanita Mary Crook
Phone: 416-946-4501 Email: clinical.trials@uhn.on.ca

Newfoundland

St. John's
Doctor H. Bliss Murphy Cancer Centre
Status: Temporarily closed to accrual
Contact: John W. Thoms
Phone: 709-777-7589

Nova Scotia

Halifax
QEII Health Sciences Centre / Nova Scotia Health Authority
Status: Temporarily closed to accrual
Contact: David Michael Charles Bowes
Phone: 902-473-6000

Ontario

London
London Regional Cancer Program
Status: Temporarily closed to accrual
Contact: George B. Rodrigues
Phone: 519-685-8600
Newmarket
Stronach Regional Health Centre at Southlake
Status: Temporarily closed to accrual
Contact: Charles Cho
Phone: 905-895-4521ext6820
Toronto
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Status: Active
Contact: Hans Chung
Phone: 416-480-5000

Quebec

Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal
Status: Active
Contact: Jean-Paul Bahary
Phone: 514-890-8000ext12725 Email: info.cr.chum@ssss.gouv.qc.ca
CHUM - Hopital Notre-Dame
Status: Active
Contact: Jean-Paul Bahary
Phone: 514-890-8000ext14788 Email: marie-josee.samson.chum@ssss.gouv.qc.ca
Jewish General Hospital
Status: Temporarily closed to accrual
Contact: Mohammad Tamim Niazi
Phone: 514-340-8222ext8248
McGill University Department of Oncology
Status: Active
Contact: Fabio Luis Biagini Cury
Phone: 514-934-4400
The Research Institute of the McGill University Health Centre (MUHC)
Status: Active
Contact: Fabio Luis Biagini Cury
Phone: 514-934-1934ext48354 Email: evelyn.ortega@muhc.mcgill.ca
Quebec City
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Status: Active
Contact: Eric Vigneault
Phone: 412-339-5294 Email: Roster@nrgoncology.org
Sherbrooke
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Status: Active
Contact: Eric Vigneault
Phone: 819-820-6480 Email: crcinformation.chus@ssss.gouv.qc.ca

Saskatchewan

Regina
Allan Blair Cancer Centre
Status: Active
Contact: Evgeny Sadikov
Phone: 306-766-2213
Saskatoon
Saskatoon Cancer Centre
Status: Active
Contact: Ali A. H. H. El-Gayed
Phone: 306-655-2914

Hong Kong

Chai Wan
Pamela Youde Nethersole Eastern Hospital
Status: Temporarily closed to accrual
Contact: Kuen Chan
Phone: 011 852 2595 7920

Israel

Petach Tikva
Rabin Medical Center
Status: Active
Contact: Aaron Max Allen
Phone: 03-9378116 X 8120
Tel Hashomer
Chaim Sheba Medical Center
Status: Temporarily closed to accrual
Contact: Zvi Symon
Phone: 972 3 530-5943

Singapore

Singapore
National Cancer Centre
Status: Active
Contact: Terence Wee Kiat Tan
Phone: 65 6225 5655 Email: cancerhelpline@nccs.com.sg
National University Hospital Singapore
Status: Temporarily closed to accrual
Contact: Keith Hsiu Chin Lim Email: horg@nuhs.edu.sg

Switzerland

Aarau
Kantonsspital Aarau
Status: Active
Contact: Stephan Beat Bodis
Phone: 41 62 838 60 50

Trial Objectives and Outline

PRIMARY OBJECTIVE:

I. Demonstrate that prophylactic, neoadjuvant, androgen-deprivation therapy (NADT) and whole-pelvic radiation therapy (WPRT) will result in improvement in overall survival (OS) in patients with “unfavorable” intermediate-risk or “favorable” high-risk prostate cancer compared to NADT and high-dose prostate and seminal vesicle (SV) radiation therapy (prostate [P] + SV radiation therapy [RT]) using intensity-modulated radiotherapy (IMRT) or external-beam RT (EBRT) with a high-dose rate (HDR) or a permanent prostate (radioactive seed) implant (PPI) boost.

SECONDARY OBJECTIVES:

I. Demonstrate that prophylactic WPRT improves biochemical control (“Phoenix definition”).

II. Distant metastasis (DM)-free survival.

III. Cause-specific survival (CSS).

IV. Compare acute and late treatment-adverse events between patients receiving NADT + WPRT versus NADT + P and SV RT.

V. Determine whether health-related quality of life (HRQOL), as measured by the Expanded Prostate Cancer Index Composite (EPIC), significantly worsens with increasing aggressiveness of treatment (i.e., Arm 2, NADT + WPRT). (closed to patient accrual 3/9/15)

VI. Determine whether more aggressive treatment (Arm 2, NADT + WPRT) is associated with a greater increase in fatigue (Patient-Reported Outcome Measurement Information System [PROMIS] Fatigue Short Form) from baseline to last week of treatment, and a greater increase in circulating inflammatory markers (interleukin [IL]-1, IL-1 receptor antagonist [ra], IL-6, tumor necrosis factor [TNF]-alpha, and C-reactive protein). (closed to patient accrual 3/9/15)

VII. Demonstrate an incremental gain in OS and CSS with more aggressive therapy that outweighs any detriments in the primary generic domains of HRQOL (i.e., mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). (closed to patient accrual 3/9/15)

VIII. Determine whether changes in fatigue from baseline to the next three time points (week prior to RT, last week of treatment, and 3 months after treatment) are associated with changes in circulating cytokines, mood, sleep, and daily activities across the same time points.

IX. Collect paraffin-embedded tissue blocks, plasma, whole blood, and urine for planned and future translational research analyses.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

All patients receive neoadjuvant androgen-deprivation therapy comprising bicalutamide orally (PO) once daily (QD) or flutamide PO thrice daily (TID) for 6 months, and luteinizing hormone-releasing hormone (LHRH) agonist/antagonist therapy comprising leuprolide acetate, goserelin acetate, buserelin, triptorelin, or degarelix subcutaneously (SC) or intramuscularly (IM) every 1 to 3 months beginning 2 months prior to radiotherapy and continuing for 4, 6 ,or 32 months. Radiotherapy begins within 8-10 weeks after beginning LHRH agonist/antagonist injection.

ARM I: Patients undergo high-dose radiotherapy of the prostate and seminal vesicles using IMRT* or 3D-conformal radiation therapy (3D-CRT)* QD, 5 days a week, for approximately 9 weeks. Patients may also undergo PPI brachytherapy or high-dose rate brachytherapy (iodine I 125 or palladium Pd 103 may be used as the radioisotope).

ARM II: Patients undergo WPRT* (3D-CRT or IMRT) QD, 5 days a week, for approximately 9 weeks. Patients may also undergo brachytherapy as in Arm I.

NOTE: * Patients undergoing brachytherapy implant receive 5 weeks of IMRT, 3D-CRT, or WPRT.

After completion of study treatment, patients are followed up every 3 months for 1 year, every 6 months for 3 years, and then yearly thereafter.

Trial Phase & Type

Trial Phase

Phase III

Trial Type

Treatment

Lead Organization

Lead Organization
NRG Oncology

Principal Investigator
Mack Roach

Trial IDs

Primary ID RTOG-0924
Secondary IDs NCI-2011-02674, CDR0000701128, PRTOG-0924_A03PAMDREVW01
Clinicaltrials.gov ID NCT01368588