Donor Stem Cell Transplant in Treating Patients With Hematological Malignancies

Inclusion Criteria

• INCLUSION CRITERIA FOR STEM CELL TRANSPLANT WITH CONDITIONING (COHORT 1):
• Patient requiring allogeneic SCT
• Age between birth and 70 years
• Patient and/or responsible person able to understand and sign consent
• INCLUSION CRITERIA FOR CD34+ TOPOFF WITHOUT CONDITIONING (COHORT 2):
• Allogeneic SCT recipient requiring additional cellular therapy
• COHORT 2: Age between birth and 70 years
• Patient and/or responsible person able to understand and sign consent
• Evidence of mixed chimerisms (less than 95% donor cells) OR
• Evidence of poor bone marrow function (bone marrow cellularity less than 50% with at least one cytopenia) OR
• Relapsed disease

Exclusion Criteria

• EXCLUSION CRITERIA FOR STEM CELL TRANSPLANT WITH CONDITIONING (COHORT 1):
• Active, acute GvHD > grade II or extensive, chronic GvHD
• Severe life, threatening infection
• Forced expiratory volume in one second (FEV1) 40% of predicted or 3 standard deviations (SD) below normal
• Forced vital capacity (FVC) 40% of predicted or 3 SD below normal
• Diffusing capacity of the lung for carbon monoxide (DLCO) 40% of predicted or 3 SD below normal
• Left ventricular shortening fraction (LVSF) less than 25%
• Psychiatric disturbance
• Lansky or Karnofsky score < 50%
• Direct bilirubin > 3x upper limit of normal
• Aspartate aminotransferase (AST) > 5x upper limit of normal
• Creatinine > 3x normal
• Known human immunodeficiency virus (HIV) positivity
• Pregnancy
• EXCLUSION CRITERIA FOR CD34+ TOPOFF WITHOUT CONDITIONING (COHORT 2):
• Active, acute GvHD > grade II or extensive, chronic GvHD
• Severe life, threatening infection