Standard or Comprehensive Radiation Therapy in Treating Patients with Early-Stage Breast Cancer Previously Treated with Chemotherapy and Surgery

Status: Active

Description

This randomized phase III trial studies radiation therapy to the breast, chest wall and lymph nodes (comprehensive) compared to standard radiation therapy to the breast in treating patients with early-stage breast cancer previously treated with chemotherapy and surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with early-stage breast cancer.

Eligibility Criteria

Inclusion Criteria

  • The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
  • The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Patient must have clinically T1-3, N1 breast cancer at the time of diagnosis (before neoadjuvant therapy); clinical axillary nodal involvement can be assessed by palpation, ultrasound, CT scan, magnetic resonance imaging (MRI), positron emission tomography (PET) scan, or PET/CT scan
  • Patient must have had pathologic confirmation of axillary nodal involvement at presentation (before neoadjuvant therapy) based on either a positive fine needle aspirate (FNA) (demonstrating malignant cells) or positive core needle biopsy (demonstrating invasive adenocarcinoma); the FNA or core needle biopsy can be performed either by palpation or by image guidance; documentation of axillary nodal positivity by sentinel node biopsy (before neoadjuvant therapy) is not permitted
  • Patients must have had estrogen receptor (ER) analysis performed on the primary breast tumor before neoadjuvant therapy according to current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for hormone receptor testing; if negative for ER, assessment of progesterone receptor (PgR) must also be performed according to current ASCO/CAP guideline recommendations for hormone receptor testing
  • Patients must have had HER2 testing performed on the primary breast tumor before neoadjuvant chemotherapy according to the current ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer; patients who have a primary tumor that is either HER2-positive or HER2-negative are eligible
  • Patient must have completed a minimum of 8 weeks of standard neoadjuvant chemotherapy consisting of an anthracycline and/or taxane-based regimen
  • For patients who receive adjuvant chemotherapy after surgery, a maximum of 12 weeks of intended chemotherapy may be administered but must be completed before randomization; (if treatment delays occur, chemotherapy must be completed within 14 weeks); the dose and schedule of the adjuvant chemotherapy are at the investigator's discretion; Note: it is preferred that all intended chemotherapy be administered in the neoadjuvant setting
  • Patients with HER2-positive tumors must have received neoadjuvant anti-HER2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen), unless medically contraindicated
  • At the time of definitive surgery, all removed axillary nodes must be histologically free from cancer; acceptable procedures for assessment of axillary nodal status at the time of surgery include: * Axillary node dissection * Sentinel node biopsy alone provided that at least 2 sentinel lymph nodes are removed; removal of at least 3 sentinel lymph nodes and use of dual tracer for lymphatic mapping are strongly recommended or * Sentinel node biopsy followed by axillary node dissection Note: patients are eligible whether there is residual invasive carcinoma in the surgical breast specimen or whether there is evidence of pathologic complete response; patients who are found to be pathologically node-positive at the time of surgery, based on sentinel node biopsy alone, are candidates for A011202, a study developed by the Alliance in Oncology, an National Cancer Institute (NCI) Cooperative Group; if A011202 is open at the investigator's institution, patients should be approached about participating in the A011202 study
  • Patients with pathologic staging of ypN0(i+) or ypN0(mol+) are eligible
  • Patient who have undergone either a total mastectomy or a lumpectomy are eligible; (patients who have had a nipple-sparing mastectomy are eligible)
  • For patients who undergo lumpectomy, the margins of the resected specimen or re-excision must be histologically free of invasive tumor and DCIS as determined by the local pathologist; additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible; (patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection)
  • For patients who undergo mastectomy, the margins must be histologically free of residual (microscopic or gross) tumor
  • The interval between the last surgery for breast cancer (including re-excision of margins) and randomization must be no more than 70 days; also, if adjuvant chemotherapy was administered, the interval between the last chemotherapy treatment and randomization must be no more than 70 days
  • The patient must have recovered from surgery with the incision completely healed and no signs of infection
  • If adjuvant chemotherapy was administered, chemotherapy-related toxicity that may interfere with delivery of radiation therapy should have resolved

Exclusion Criteria

  • Definitive clinical or radiologic evidence of metastatic disease
  • T4 tumors including inflammatory breast cancer
  • Documentation of axillary nodal positivity before neoadjuvant therapy by sentinel node biopsy alone
  • N2 or N3 disease detected clinically or by imaging
  • Patients with histologically positive axillary nodes post neoadjuvant therapy
  • Patients with microscopic positive margins after definitive surgery
  • Synchronous or previous contralateral invasive breast cancer or DCIS; (patients with synchronous and/or previous contralateral LCIS are eligible)
  • Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy; (patients with synchronous or previous ipsilateral LCIS are eligible)
  • History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
  • Any radiation therapy for the currently diagnosed breast cancer prior to randomization
  • Any continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy; patients are eligible if these medications are discontinued prior to randomization
  • Prior breast or thoracic radiation therapy (RT) for any condition
  • Active collagen vascular disease, specifically dermatomyositis with a creatinine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma
  • Pregnancy or lactation at the time of study entry; (Note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
  • Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements

Locations & Contacts

Alabama

Mobile
University of South Alabama Mitchell Cancer Institute
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 251-445-9870
Email: pfrancisco@usouthal.edu

Alaska

Anchorage
Alaska Oncology and Hematology LLC
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Status: Active
Contact: Site Public Contact
Phone: 907-212-6871
Email: AKPAMC.OncologyResearchSupport@providence.org

Arizona

Gilbert
Arizona Breast Cancer Specialists-Gilbert
Status: Active
Contact: Site Public Contact
Phone: 480-922-4600
Banner MD Anderson Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 602-747-9738
Goodyear
CTCA at Western Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 623-207-3000
Peoria
Arizona Center for Cancer Care-Peoria
Status: Active
Contact: Site Public Contact
Phone: 623-773-2873
Phoenix
Arizona Breast Cancer Specialists-Phoenix
Status: Active
Contact: Site Public Contact
Phone: 480-922-4600
Email: renee.schein@arizonaccc.com
Scottsdale
Arizona Breast Cancer Specialists
Status: Active
Contact: Site Public Contact
Phone: 480-922-4600
Arizona Breast Cancer Specialists-Scottsdale
Status: Active
Contact: Site Public Contact
Phone: 480-922-4600
Surprise
Arizona Center for Cancer Care-Surprise
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Tucson
Arizona Oncology Associates-West Orange Grove
Status: Active
Contact: Site Public Contact
Phone: 520-544-2919

Arkansas

Little Rock
University of Arkansas for Medical Sciences
Status: Active
Contact: Site Public Contact
Phone: 501-686-8274

California

Auburn
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Bakersfield
AIS Cancer Center at San Joaquin Community Hospital
Status: Active
Contact: Site Public Contact
Phone: 661-323-4673
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 818-847-4793
Email: Najee.Boucher@providence.org
Burlingame
Mills-Peninsula Medical Center
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Clovis
Community Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 559-387-1827
Duarte
City of Hope Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-826-4673
Email: becomingapatient@coh.org
Dublin
Epic Care-Dublin
Status: Active
Contact: Site Public Contact
Phone: 925-875-1677
Emeryville
Epic Care Partners in Cancer Care
Status: Active
Contact: Site Public Contact
Phone: 510-629-6682
La Jolla
UC San Diego Moores Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 858-822-5354
Email: cancercto@ucsd.edu
Lancaster
City of Hope Antelope Valley
Status: Active
Contact: Site Public Contact
Phone: 800-826-4673
Email: becomingapatient@coh.org
Loma Linda
Loma Linda University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 909-558-3375
Los Angeles
Cedars Sinai Medical Center
Status: Active
Contact: Site Public Contact
Phone: 310-423-8965
Kaiser Permanente Los Angeles Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-398-3996
Email: clinical.trials@kp.org
Los Angeles County-USC Medical Center
Status: Active
Contact: Site Public Contact
Phone: 323-865-0451
USC / Norris Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 323-865-0451
Marysville
Fremont - Rideout Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 530-749-4400
Modesto
Memorial Medical Center
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Newport Beach
Hoag Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 949-722-6237
Email: HoagCancerCenter@hoag.org
Oakland
Alta Bates Summit Medical Center - Summit Campus
Status: Active
Contact: Site Public Contact
Phone: 510-204-1414
Kaiser Permanente Oakland-Broadway
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Orange
Saint Joseph Hospital - Orange
Status: Active
Contact: Site Public Contact
Phone: 714-734-6220
UC Irvine Health / Chao Family Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-827-8839
Email: ucstudy@uci.edu
Palm Springs
Desert Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 760-416-4730
Pasadena
Huntington Memorial Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 626-535-2420
Pomona
Pomona Valley Hospital Medical Center
Status: Active
Contact: Site Public Contact
Phone: 909-865-9555
Rancho Cordova
Kaiser Permanente-Rancho Cordova Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Rohnert Park
Rohnert Park Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Roseville
Kaiser Permanente-Roseville
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Sutter Roseville Medical Center
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
The Permanente Medical Group-Roseville Radiation Oncology
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Sacramento
Sutter Medical Center Sacramento
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
University of California Davis Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 916-734-3089
Saint Helena
Saint Helena Hospital
Status: Active
Contact: Site Public Contact
Phone: 707-967-3698
San Diego
Naval Medical Center -San Diego
Status: Active
Contact: Site Public Contact
Phone: 619-532-8712
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Santa Rosa
Saint Joseph Heritage Healthcare-Santa Rosa
Status: Active
Contact: Site Public Contact
Phone: 707-521-3830
South Pasadena
City of Hope South Pasadena
Status: Active
Contact: Site Public Contact
Phone: 800-826-4673
Email: becomingapatient@coh.org
South San Francisco
Kaiser Permanente Cancer Treatment Center
Status: Active
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Kaiser Permanente-South San Francisco
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 877-642-4691
Email: Kpoct@kp.org
Truckee
Gene Upshaw Memorial Tahoe Forest Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 530-582-6450
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org
Vallejo
Sutter Solano Medical Center / Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 415-209-2686
Email: bernicl@sutterhealth.org

Colorado

Aurora
Rocky Mountain Cancer Centers-Aurora
Status: Active
Contact: Site Public Contact
Phone: 303-777-2663
Email: ccrp@co-cancerresearch.org
University of Colorado Hospital
Status: Active
Contact: Site Public Contact
Phone: 720-848-0650
Boulder
Rocky Mountain Cancer Centers-Boulder
Status: Active
Contact: Site Public Contact
Phone: 303-777-2663
Email: ccrp@co-cancerresearch.org
Colorado Springs
Penrose-Saint Francis Healthcare
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
UCHealth Memorial Hospital Central
Status: Active
Contact: Site Public Contact
Phone: 719-365-2406
Denver
Porter Adventist Hospital
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Edwards
Shaw Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 970-569-7429
Englewood
Swedish Medical Center
Status: Active
Contact: Site Public Contact
Phone: 303-777-2663
Email: ccrp@co-cancerresearch.org
Fort Collins
Poudre Valley Hospital
Status: Active
Contact: Site Public Contact
Phone: 970-297-6150
Littleton
Rocky Mountain Cancer Centers-Littleton
Status: Active
Contact: Site Public Contact
Phone: 303-777-2663
Email: ccrp@co-cancerresearch.org
Pueblo
Saint Mary Corwin Medical Center
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Thornton
Rocky Mountain Cancer Centers-Thornton
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Wheat Ridge
SCL Health Lutheran Medical Center
Status: Active
Contact: Site Public Contact
Phone: 303-777-2663
Email: ccrp@co-cancerresearch.org

Connecticut

Hartford
Hartford Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 860-545-5363
Middletown
Middlesex Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 860-358-2058
Email: beth_slifer@midhosp.org
New Britain
The Hospital of Central Connecticut
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 860-224-5660
Stamford
Stamford Hospital / Bennett Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 203-323-8944

Delaware

Newark
Christiana Care Health System-Christiana Hospital
Status: Active
Contact: Site Public Contact
Phone: 302-623-4450
Email: KDempsey@christianacare.org
Helen F Graham Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 302-623-4450
Email: KDempsey@christianacare.org

District of Columbia

Washington
MedStar Georgetown University Hospital
Status: Active
Contact: Site Public Contact
Phone: 202-444-2223
MedStar Washington Hospital Center
Status: Active
Contact: Site Public Contact
Phone: 202-877-8839
Sibley Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 202-243-2373
Email: jquiver1@jhmi.edu

Florida

Altamonte Springs
AdventHealth Altamonte
Status: Active
Contact: Site Public Contact
Phone: 407-303-2200
Atlantis
John Fitzgerald Kennedy Medical Center
Status: Active
Contact: Site Public Contact
Phone: 561-964-2662
Boca Raton
Boca Raton Regional Hospital
Status: Active
Contact: Site Public Contact
Phone: 561-955-4800
Clearwater
Morton Plant Hospital
Status: Active
Contact: Site Public Contact
Phone: 855-314-8646
Coral Gables
UM Sylvester Comprehensive Cancer Center at Coral Gables
Status: Active
Contact: Site Public Contact
Phone: 305-243-2647
Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Status: Active
Contact: Site Public Contact
Phone: 305-243-2647
Gainesville
University of Florida Health Science Center - Gainesville
Status: Active
Contact: Site Public Contact
Phone: 352-273-8010
Email: cancer-center@ufl.edu
Hollywood
Memorial Regional Hospital / Joe DiMaggio Children's Hospital
Status: Active
Contact: Site Public Contact
Phone: 954-265-1847
Email: OHR@mhs.net
Jacksonville
Mayo Clinic in Florida
Status: Active
Contact: Site Public Contact
Phone: 855-776-0015
Lakeland
Lakeland Regional Health Hollis Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 863-904-1900
Miami
Jackson Memorial Hospital-Holtz Children's Hospital
Status: Active
Contact: Site Public Contact
Phone: 305-243-3975
Miami Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 786-596-2000
South Miami Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-599-2456
Email: CancerInfo@BaptistHealth.net
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 305-243-2647
Orlando
AdventHealth Orlando
Status: Active
Contact: Site Public Contact
Phone: 407-303-2090
Email: FH.Cancer.Research@flhosp.org
UF Cancer Center at Orlando Health
Status: Active
Contact: Site Public Contact
Phone: 321-841-7246
Email: CancerClinicalTrials@orlandohealth.com
Tampa
Moffitt Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-679-0775
Email: canceranswers@moffitt.org
Saint Joseph's Hospital / Children's Hospital-Tampa
Status: Active
Contact: Site Public Contact
Phone: 813-356-7168
Email: Katelynn.Colgain@baycare.org
Weston
Cleveland Clinic-Weston
Status: Active
Contact: Site Public Contact
Phone: 954-659-5705
Email: CancerAnswer@ccf.org

Georgia

Atlanta
Emory Saint Joseph's Hospital
Status: Active
Contact: Site Public Contact
Phone: 404-851-7115
Emory University Hospital / Winship Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 404-778-1868
Emory University Hospital Midtown
Status: Active
Contact: Site Public Contact
Phone: 888-946-7447
Grady Health System
Status: Active
Contact: Site Public Contact
Phone: 404-489-9164
Piedmont Hospital
Status: Active
Contact: Site Public Contact
Phone: 404-425-7943
Email: ORS@piedmont.org
Augusta
Augusta University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 706-721-2388
Email: ga_cares@augusta.edu
Carrollton
Tanner Medical Center / Carrollton
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 770-836-9824
Decatur
Dekalb Medical Center
Status: Active
Contact: Site Public Contact
Phone: 404-501-2738
Email: clinicaltrialsoncology@dekalbmedical.org
Fayetteville
Piedmont Fayette Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Newnan
CTCA at Southeastern Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 770-400-6629
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: Active
Contact: Site Public Contact
Phone: 912-819-5704
Email: underberga@sjchs.org
Memorial Health University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 912-350-7887
Email: clayter1@memorialhealth.com

Hawaii

Aiea
The Cancer Center of Hawaii-Pali Momi
Status: Active
Contact: Site Public Contact
Phone: 808-678-9000
Honolulu
Queen's Medical Center
Status: Active
Contact: Site Public Contact
Phone: 808-545-8548
The Cancer Center of Hawaii-Liliha
Status: Active
Contact: Site Public Contact
Phone: 808-547-6881

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute
Status: Active
Contact: Site Public Contact
Phone: 208-381-2774
Email: eslinget@slhs.org
Nampa
Saint Luke's Mountain States Tumor Institute - Nampa
Status: Active
Contact: Site Public Contact
Phone: 208-381-8059
Email: hallsc@slhs.org
Post Falls
Kootenai Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 406-969-6060
Email: mccinfo@mtcancer.org

Illinois

Chicago
John H Stroger Jr Hospital of Cook County
Status: Active
Contact: Site Public Contact
Phone: 312-864-5204
Mount Sinai Hospital Medical Center
Status: Active
Contact: Site Public Contact
Phone: 773-257-5960
Email: suhi@sinai.org
Rush University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 312-942-5498
Email: clinical_trials@rush.edu
Swedish Covenant Hospital
Status: Active
Contact: Site Public Contact
Phone: 773-878-8200
University of Chicago Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 773-702-8222
Email: cancerclinicaltrials@bsd.uchicago.edu
University of Illinois
Status: Active
Contact: Site Public Contact
Phone: 312-355-3046
Decatur
Decatur Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 217-876-4740
Email: rhamrick@dmhhs.org
Effingham
Crossroads Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 217-876-4740
Email: rhamrick@dmhhs.org
Elk Grove Village
AMITA Health Alexian Brothers Medical Center
Status: Active
Contact: Site Public Contact
Phone: 847-952-7164
Email: fredianc@alexian.net
Elmhurst
Elmhurst Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 630-758-5460
Email: Jrohde@emhc.org
Evanston
NorthShore University HealthSystem-Evanston Hospital
Status: Active
Contact: Site Public Contact
Phone: 847-570-2109
Geneva
Northwestern Medicine Cancer Center Delnor
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 630-315-1918
Email: Claudine.Gamster@CadenceHealth.org
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Status: Active
Contact: Site Public Contact
Phone: 847-570-2109
Hazel Crest
Advocate South Suburban Hospital
Status: Active
Contact: Site Public Contact
Phone: 708-799-9995
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Status: Active
Contact: Site Public Contact
Phone: 847-570-2109
Hinsdale
AMITA Health Cancer Institute and Outpatient Center
Status: Active
Contact: Site Public Contact
Phone: 630-286-5500
Lake Forest
Northwestern Medicine Lake Forest Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Maywood
Loyola University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 708-226-4357
Naperville
Edward Hospital / Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 630-646-6075
New Lenox
UC Comprehensive Cancer Center at Silver Cross
Status: Active
Contact: Site Public Contact
Phone: 773-702-8222
Email: cancerclinicaltrials@bsd.uchicago.edu
Oak Lawn
Advocate Christ Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-323-8622
Orland Park
University of Chicago Medicine-Orland Park
Status: Active
Contact: Site Public Contact
Phone: 773-702-8222
Email: cancerclinicaltrials@bsd.uchicago.edu
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Park Ridge
Advocate Lutheran General Hospital
Status: Active
Contact: Site Public Contact
Phone: 847-384-3621
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Medical Center
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Plainfield
Edward Hospital / Cancer Center?Plainfield
Status: Active
Contact: Site Public Contact
Phone: 630-646-6075
Email: Cancerresearch@edward.org
Princeton
Illinois CancerCare-Princeton
Status: Active
Contact: Site Public Contact
Phone: 309-243-3605
Email: andersonj@illinoiscancercare.com
Rockford
SwedishAmerican Regional Cancer Center / ACT
Status: Active
Contact: Site Public Contact
Phone: 779-696-9400
Email: cancercare@swedishamerican.org
Springfield
Memorial Medical Center
Status: Active
Contact: Site Public Contact
Phone: 217-788-3528
Swansea
Southwest Illinois Health Services LLP
Status: Active
Contact: Site Public Contact
Phone: 618-236-1000
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-446-5532
Email: Research@carle.com
Warrenville
Northwestern Medicine Cancer Center Warrenville
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 630-315-1918
Email: Claudine.Gamster@CadenceHealth.org
Zion
Midwestern Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org

Indiana

Goshen
Goshen Center for Cancer Care
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 574-364-2973
Email: cccois@goshenhealth.com
Indianapolis
Community Cancer Center East
Status: Active
Contact: Site Public Contact
Phone: 317-497-2823
Email: lcheri@ecommunity.com
Community Cancer Center North
Status: Active
Contact: Site Public Contact
Phone: 317-497-2823
Email: lcheri@ecommunity.com
Community Cancer Center South
Status: Active
Contact: Site Public Contact
Phone: 317-497-2823
Email: lcheri@ecommunity.com
Franciscan Health Indianapolis
Status: Active
Contact: Site Public Contact
Phone: 317-528-7060
IU Health Methodist Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 317-278-5632
Email: iutrials@iu.edu
South Bend
Memorial Hospital of South Bend
Status: Active
Contact: Site Public Contact
Phone: 800-284-7370

Iowa

Clive
Mercy Cancer Center-West Lakes
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Des Moines
Iowa Methodist Medical Center
Status: Active
Contact: Site Public Contact
Phone: 515-241-6727
Mercy Medical Center - Des Moines
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org

Kansas

Kansas City
University of Kansas Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 913-945-7552
Email: ctnursenav@kumc.edu
Overland Park
University of Kansas Cancer Center-Overland Park
Status: Active
Contact: Site Public Contact
Phone: 913-945-7552
Email: ctnursenav@kumc.edu

Kentucky

Edgewood
Saint Elizabeth Medical Center South
Status: Active
Contact: Site Public Contact
Phone: 859-301-5473
Email: darla.hehman@stelizabeth.com
Fort Thomas
Saint Elizabeth Fort Thomas
Status: Active
Contact: Site Public Contact
Phone: 859-301-9418
Lexington
University of Kentucky / Markey Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 859-257-3379
Louisville
Baptist Health Louisville
Status: Active
Contact: Site Public Contact
Phone: 502-897-8592
Email: Cbcresearch@bhsi.com
Norton Hospital Pavilion and Medical Campus
Status: Active
Contact: Site Public Contact
Phone: 502-629-2500
Norton Suburban Hospital and Medical Campus
Status: Active
Contact: Site Public Contact
Phone: 502-629-3465
The James Graham Brown Cancer Center at University of Louisville
Status: Active
Contact: Site Public Contact
Phone: 502-562-3429
Owensboro
Owensboro Health Mitchell Memorial Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 270-688-3691
Email: shawns@omhs.org

Louisiana

Baton Rouge
Baton Rouge General Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 225-381-6451
Mary Bird Perkins Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 225-215-1353
Email: clinicalresearch@marybird.com
Woman's Hospital
Status: Active
Contact: Site Public Contact
Phone: 225-215-1353
Email: Clinicalreserach@marybird.com
Covington
Mary Bird Perkins Cancer Center - Covington
Status: Active
Contact: Site Public Contact
Phone: 225-215-1353
Email: clinicalresearch@marybird.com
Houma
Mary Bird Perkins Cancer Center - Houma
Status: Active
Contact: Site Public Contact
Phone: 225-215-1353
Email: clinicalresearch@marybird.com
Kenner
Ochsner Medical Center Kenner
Status: Active
Contact: Site Public Contact
Phone: 504-464-8314
Email: cris.molina@ochsner.org
New Orleans
Ochsner Medical Center Jefferson
Status: Active
Contact: Site Public Contact
Phone: 504-703-8712
Email: Gregory.Johnstone@ochsner.org
University Medical Center New Orleans
Status: Active
Contact: Site Public Contact
Phone: 504-210-3539
Email: emede1@lsuhsc.edu

Maine

Bangor
Eastern Maine Medical Center
Status: Active
Contact: Site Public Contact
Phone: 207-973-4274
Bath
MaineHealth Coastal Cancer Treatment Center
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Biddeford
MaineHealth / SMHC Cancer Care and Blood Disorders-Biddeford
Status: Active
Contact: Site Public Contact
Email: LLemire@mmc.org
Portland
Maine Medical Center-Bramhall Campus
Status: Active
Contact: Site Public Contact
Phone: 207-885-7565
Sanford
MaineHealth / SMHC Cancer Care and Blood Disorders-Sanford
Status: Active
Contact: Site Public Contact
Email: LLemire@mmc.org
MaineHealth Cancer Care Center of York County
Status: Active
Contact: Site Public Contact
Phone: 207-459-1600
Scarborough
Maine Medical Center- Scarborough Campus
Status: Active
Contact: Site Public Contact
Phone: 207-396-8090
Email: wrighd@mmc.org

Maryland

Annapolis
Anne Arundel Medical Center
Status: Active
Contact: Site Public Contact
Phone: 443-481-1320
Email: kbodenhorn@aahs.org
Baltimore
Greater Baltimore Medical Center
Status: Active
Contact: Site Public Contact
Phone: 443-849-3706
Johns Hopkins University / Sidney Kimmel Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 410-955-8804
Email: jhcccro@jhmi.edu
MedStar Franklin Square Medical Center / Weinberg Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 443-777-7364
Saint Agnes Hospital
Status: Active
Contact: Site Public Contact
Phone: 410-368-2910
University of Maryland / Greenebaum Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-888-8823
Bel Air
UM Upper Chesapeake Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 443-643-3010
Bethesda
Suburban Hospital
Status: Active
Contact: Site Public Contact
Phone: 301-896-2719
Email: bsquill1@jhmi.edu
Columbia
Central Maryland Radiation Oncology in Howard County
Status: Active
Contact: Site Public Contact
Phone: 443-546-1300
Glen Burnie
UM Baltimore Washington Medical Center / Tate Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 410-553-8100

Massachusetts

Boston
Dana-Farber Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 877-442-3324
Massachusetts General Hospital Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-726-5130
Burlington
Lahey Hospital and Medical Center
Status: Active
Contact: Site Public Contact
Phone: 781-744-8027
Fall River
Saint Anne's Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 508-674-5600ext2515
Lowell
Lowell General Hospital
Status: Active
Contact: Site Public Contact
Phone: 978-788-7084
Email: ghincks@lowellgeneral.org
Springfield
Baystate Medical Center
Status: Active
Contact: Site Public Contact
Phone: 413-794-3565
Email: tamara.wrenn@baystatehealth.org

Michigan

Bay City
McLaren Cancer Institute-Bay City
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Brownstown
Henry Ford Cancer Institute-Downriver
Status: Active
Contact: Site Public Contact
Phone: 313-916-3721
Email: CTOResearch@hfhs.org
Clarkston
21st Century Oncology MHP - Clarkston
Status: Active
Contact: Site Public Contact
Phone: 248-338-0663
McLaren Cancer Institute-Clarkston
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Clinton Township
Henry Ford Macomb Hospital-Clinton Township
Status: Active
Contact: Site Public Contact
Phone: 313-916-3721
Email: CTOResearch@hfhs.org
Dearborn
Beaumont Hospital – Dearborn
Status: Active
Contact: Site Public Contact
Phone: 248-551-7695
Detroit
Ascension Saint John Hospital
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Henry Ford Hospital
Status: Active
Contact: Site Public Contact
Phone: 313-916-3721
Email: CTOResearch@hfhs.org
Wayne State University / Karmanos Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Farmington Hills
21st Century Oncology MHP - Farmington
Status: Active
Contact: Site Public Contact
Phone: 248-338-0663
Beaumont Hospital - Farmington Hills
Status: Active
Contact: Site Public Contact
Phone: 248-551-7695
Flint
Genesys Hurley Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Hurley Medical Center
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
McLaren Cancer Institute-Flint
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Grand Rapids
Mercy Health Saint Mary's
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org
Spectrum Health at Butterworth Campus
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org
Lansing
McLaren-Greater Lansing
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Sparrow Hospital
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Lapeer
McLaren Cancer Institute-Lapeer Region
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Mount Clemens
McLaren Cancer Institute-Macomb
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Mount Pleasant
McLaren Cancer Institute-Central Michigan
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Muskegon
Mercy Health Mercy Campus
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org
Novi
Ascension Providence Hospitals - Novi
Status: Active
Contact: Site Public Contact
Phone: 248-849-5332
Email: karen.fife@ascension.org
Owosso
McLaren Cancer Institute-Owosso
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Petoskey
McLaren Cancer Institute-Northern Michigan
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Pontiac
Saint Joseph Mercy Oakland
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Port Huron
McLaren-Port Huron
Status: Active
Contact: Site Public Contact
Phone: 313-576-9790
Email: ctoadmin@karmanos.org
Royal Oak
William Beaumont Hospital-Royal Oak
Status: Active
Contact: Site Public Contact
Phone: 248-551-7695
Saint Joseph
Lakeland Medical Center Saint Joseph
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org
Southfield
Ascension Providence Hospitals - Southfield
Status: Active
Contact: Site Public Contact
Phone: 248-849-5332
Email: karen.fife@ascension.org
Traverse City
Munson Medical Center
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org
Troy
21st Century Oncology MHP - Troy
Status: Active
Contact: Site Public Contact
Phone: 248-338-0663
William Beaumont Hospital - Troy
Status: Active
Contact: Site Public Contact
Phone: 248-551-7695
Warren
Saint John Macomb-Oakland Hospital
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
West Bloomfield
Henry Ford West Bloomfield Hospital
Status: Active
Contact: Site Public Contact
Phone: 313-916-3721
Email: CTOResearch@hfhs.org
Wyoming
Metro Health Hospital
Status: Active
Contact: Site Public Contact
Phone: 616-391-1230
Email: crcwm-regulatory@crcwm.org

Minnesota

Albert Lea
Mayo Clinic Health System in Albert Lea
Status: Active
Contact: Site Public Contact
Phone: 855-776-0015
Burnsville
Fairview Ridges Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Edina
Fairview-Southdale Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Fridley
Unity Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Mankato
Mayo Clinic Health Systems-Mankato
Status: Active
Contact: Site Public Contact
Phone: 855-776-0015
Maple Grove
Fairview Maple Grove Medical Center
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Northfield
Mayo Clinic Radiation Therapy-Northfield
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 855-776-0015
Rochester
Mayo Clinic
Status: Active
Contact: Site Public Contact
Phone: 855-776-0015
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Status: Active
Contact: Site Public Contact
Phone: 877-229-4907
Email: coborncancercenter@centracare.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
United Hospital
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com
Waconia
Ridgeview Medical Center
Status: Active
Contact: Site Public Contact
Phone: 952-993-1517
Email: mmcorc@healthpartners.com

Mississippi

Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Status: Active
Contact: Site Public Contact
Phone: 901-226-1366
Email: BCCclintrials@bmhcc.org

Missouri

Cape Girardeau
Saint Francis Medical Center
Status: Active
Contact: Site Public Contact
Phone: 573-334-2230
Email: sfmc@sfmc.net
Columbia
University of Missouri - Ellis Fischel
Status: Active
Contact: Site Public Contact
Phone: 573-882-7440
Creve Coeur
Siteman Cancer Center at West County Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-600-3606
Email: info@siteman.wustl.edu
Jefferson City
Capital Region Southwest Campus
Status: Active
Contact: Site Public Contact
Phone: 573-632-4814
Email: swooden@mail.crmc.org
Joplin
Freeman Health System
Status: Active
Contact: Site Public Contact
Phone: 417-347-4030
Email: LJCrockett@freemanhealth.com
Kansas City
North Kansas City Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 816-691-1599
Research Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 913-948-5588
Email: aroland@kccop.org
The University of Kansas Cancer Center-North
Status: Active
Contact: Site Public Contact
Phone: 913-945-7552
Email: ctnursenav@kumc.edu
The University of Kansas Cancer Center-South
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 913-945-7552
Email: ctnursenav@kumc.edu
Lee's Summit
The University of Kansas Cancer Center-Lee's Summit
Status: Active
Contact: Site Public Contact
Phone: 913-945-7552
Email: ctnursenav@kumc.edu
Saint Louis
Mercy Hospital South
Status: Active
Contact: Site Public Contact
Email: janet.lesko@mercy.net
Missouri Baptist Medical Center
Status: Active
Contact: Site Public Contact
Phone: 314-996-5569
Siteman Cancer Center-South County
Status: Active
Contact: Site Public Contact
Phone: 800-600-3606
Email: info@siteman.wustl.edu
Washington University School of Medicine
Status: Active
Contact: Site Public Contact
Phone: 800-600-3606
Email: info@siteman.wustl.edu
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-600-3606
Email: info@siteman.wustl.edu

Montana

Billings
Billings Clinic Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-996-2663
Email: research@billingsclinic.org
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 406-969-6060
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 406-969-6060
Email: mccinfo@mtcancer.org
Missoula
Community Medical Hospital
Status: Active
Contact: Site Public Contact
Phone: 406-969-6060
Email: mccinfo@mtcancer.org

Nebraska

Grand Island
CHI Health Saint Francis
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Omaha
Alegent Health Bergan Mercy Medical Center
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Alegent Health Lakeside Hospital
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Nebraska Methodist Hospital
Status: Active
Contact: Site Public Contact
Phone: 402-354-5144
University of Nebraska Medical Center
Status: Active
Contact: Site Public Contact
Phone: 402-559-6941
Email: unmcrsa@unmc.edu

Nevada

Las Vegas
Comprehensive Cancer Centers of Nevada
Status: Active
Contact: Site Public Contact
Phone: 702-384-0013
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Status: Active
Contact: Site Public Contact
Phone: 702-384-0013
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Status: Active
Contact: Site Public Contact
Phone: 702-384-0013
Email: research@sncrf.org
Reno
Renown Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 702-384-0013
Email: research@sncrf.org

New Hampshire

Concord
Concord Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-441-1138
Exeter
Exeter Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-439-3837
Lebanon
Dartmouth Hitchcock Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu
Manchester
Elliot Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 603-663-1800

New Jersey

Basking Ridge
Memorial Sloan Kettering Basking Ridge
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
Brick
Ocean Medical Center
Status: Active
Contact: Site Public Contact
Phone: 732-206-8384
Camden
Cooper Hospital University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 856-325-6757
Englewood
Englewood Hospital and Medical Center
Status: Active
Contact: Site Public Contact
Phone: 201-894-3456
Hackensack
Hackensack University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 201-996-2879
Hamilton
The Cancer Institute of New Jersey Hamilton
Status: Active
Contact: Site Public Contact
Phone: 609-631-6946
Livingston
Saint Barnabas Medical Center
Status: Active
Contact: Site Public Contact
Phone: 973-322-2934
Email: joanne.loeb@rwjbh.org
Middletown
Memorial Sloan Kettering Monmouth
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
Montvale
Memorial Sloan Kettering Bergen
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
Mount Holly
Virtua Memorial
Status: Active
Contact: Site Public Contact
Phone: 609-914-6762
Neptune
Jersey Shore Medical Center
Status: Active
Contact: Site Public Contact
Phone: 732-776-4240
New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
Status: Active
Contact: Site Public Contact
Phone: 732-235-8675
Paramus
The Valley Hospital-Luckow Pavilion
Status: Active
Contact: Site Public Contact
Phone: 201-634-5792
Red Bank
Riverview Medical Center / Booker Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 732-530-2382
Ridgewood
Valley Hospital
Status: Active
Contact: Site Public Contact
Phone: 201-634-5792
Email: cparish@valleyhealth.com
Sewell
Kennedy Health Systems-Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 856-218-5790
Email: t.carducci@kennedyhealth.org
Somerville
Robert Wood Johnson University Hospital Somerset
Status: Active
Contact: Site Public Contact
Phone: 908-685-2481
Sparta
Sparta Cancer Treatment Center
Status: Active
Contact: Site Public Contact
Phone: 973-729-7001
Voorhees
MD Anderson Cancer Center at Cooper-Voorhees
Status: Active
Contact: Site Public Contact
Phone: 856-325-6757
Virtua Voorhees
Status: Active
Contact: Site Public Contact
Phone: 856-247-7395
Westwood
Valley Health System-Hematology / Oncology
Status: Active
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com

New Mexico

Albuquerque
Lovelace Radiation Oncology
Status: Active
Contact: Site Public Contact
Phone: 505-272-0530
Email: AYost@nmcca.org
New Mexico Oncology Hematology Consultants
Status: Active
Contact: Site Public Contact
Phone: 505-272-0530
Email: CLee@nmcca.org
University of New Mexico Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 505-925-0366
Email: LByatt@nmcca.org
Las Cruces
Memorial Medical Center - Las Cruces
Status: Active
Contact: Site Public Contact
Phone: 575-556-6545
Email: Kim.Hoffman@lpnt.net
Santa Fe
Christus Saint Vincent Regional Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 505-913-8933
Email: Olivia.Sloan@nmcancercare.com

New York

Bronx
Montefiore Medical Center - Moses Campus
Status: Active
Contact: Site Public Contact
Phone: 718-379-6866
Email: aaraiza@montefiore.org
Montefiore Medical Center-Einstein Campus
Status: Active
Contact: Site Public Contact
Phone: 718-379-6866
Email: aaraiza@montefiore.org
Brooklyn
Maimonides Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 718-765-2500
Buffalo
Roswell Park Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 800-767-9355
Email: askroswell@roswellpark.org
Carmel
Putnam Hospital Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com
Commack
Memorial Sloan Kettering Commack
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
Cooperstown
Mary Imogene Bassett Hospital
Status: Active
Contact: Site Public Contact
Phone: 877-547-1750
Email: CancerClinicalTrials@bassett.org
Fishkill
Vassar Brothers Fishkill Radiation Oncology Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 845-838-8103
Kingston
Ulster Radiation Oncology Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 845-339-7700
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 212-263-4434
Email: prmc.coordinator@nyumc.org
Memorial Sloan Kettering Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 212-305-6361
Email: nr2616@cumc.columbia.edu
Poughkeepsie
Vassar Brothers Medical Center
Status: Active
Contact: Site Public Contact
Phone: 845-483-6483
Rochester
Rochester General Hospital
Status: Active
Contact: Site Public Contact
Phone: 585-922-3536
Email: tia.derosa@rochestergeneral.org
Stony Brook
Stony Brook University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-862-2215
Syracuse
State University of New York Upstate Medical University
Status: Active
Contact: Site Public Contact
Phone: 315-464-5476
SUNY Upstate Medical Center-Community Campus
Status: Active
Contact: Site Public Contact
Phone: 315-464-5476
Uniondale
Memorial Sloan Kettering Nassau
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592
West Harrison
Memorial Sloan Kettering Westchester
Status: Active
Contact: Site Public Contact
Phone: 212-639-7592

North Carolina

Asheville
Hope Women's Cancer Centers-Asheville
Status: Active
Contact: Site Public Contact
Phone: 828-670-8403
Email: courtney.trafford@msj.org
Mission Hospital Inc-Memorial Campus
Status: Active
Contact: Site Public Contact
Phone: 828-213-4150
Email: leslie.verner@msj.org
Charlotte
Atrium Health Pineville / LCI-Pineville
Status: Active
Contact: Site Public Contact
Phone: 980-442-2000
Atrium Health University City / LCI-University
Status: Active
Contact: Site Public Contact
Phone: 800-804-9376
Carolinas Medical Center / Levine Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 800-804-9376
Novant Health Presbyterian Medical Center
Status: Active
Contact: Site Public Contact
Phone: 704-384-5369
Email: nnechiporchik@novanthealth.org
Concord
Atrium Health Cabarrus / LCI-Concord
Status: Active
Contact: Site Public Contact
Phone: 800-804-9376
Durham
Duke University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 888-275-3853
Gastonia
CaroMont Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 704-834-2810
Email: tammy.cozad@caromonthealth.org
Greensboro
Cone Health Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 336-832-0821
Email: vivian.sheidler@conehealth.com
Greenville
East Carolina University
Status: Active
Contact: Site Public Contact
Phone: 252-744-1015
Email: eubankss@ecu.edu
Matthews
Matthews Radiation Oncology Center
Status: Active
Contact: Site Public Contact
Phone: 704-384-8920
Email: nnechiporchik@novanthealth.org
Monroe
Atrium Health Union / LCI-Union
Status: Active
Contact: Site Public Contact
Phone: 980-442-2000
Supply
NHRMC Radiation Oncology - Supply
Status: Active
Contact: Site Public Contact
Phone: 910-754-4716
Wilmington
NHRMC Radiation Oncology - 16th Street
Status: Active
Contact: Site Public Contact
Phone: 910-251-1839
Winston-Salem
Wake Forest University Health Sciences
Status: Active
Contact: Site Public Contact
Phone: 336-713-6771

Ohio

Akron
Cleveland Clinic Akron General
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Summa Akron City Hospital / Cooper Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 330-375-6101
Barberton
Summa Barberton Hospital
Status: Active
Contact: Site Public Contact
Phone: 330-615-4132
Beachwood
UHHS-Chagrin Highlands Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Canton
Aultman Health Foundation
Status: Active
Contact: Site Public Contact
Phone: 330-363-7274
Email: ClinicalReserachDept@aultman.com
Chardon
Geauga Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Chillicothe
Adena Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 877-779-7585
Email: sheree@columbusccop.org
Cincinnati
Bethesda North Hospital
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Good Samaritan Hospital - Cincinnati
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
The Christ Hospital
Status: Active
Contact: Site Public Contact
Phone: 513-585-0844
University of Cincinnati / Barrett Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 513-558-4553
Email: uchealthnews@uc.edu
Cleveland
Case Western Reserve University
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Cleveland Clinic Cancer Center / Fairview Hospital
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Cleveland Clinic Foundation
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Columbus
Mount Carmel Health Center West
Status: Active
Contact: Site Public Contact
Phone: 614-234-5433
Email: sheree@columbusccop.org
Ohio State University Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-293-5066
Email: Jamesline@osumc.edu
Riverside Methodist Hospital
Status: Active
Contact: Site Public Contact
Phone: 614-566-4475
Email: sheree@columbusccop.org
The Mark H Zangmeister Center
Status: Active
Contact: Site Public Contact
Phone: 614-488-2118
Email: sheree@columbusccop.org
Delaware
Delaware Radiation Oncology
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 614-488-2118
Email: sheree@columbusccop.org
Elyria
Mercy Cancer Center-Elyria
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Independence
Cleveland Clinic Cancer Center Independence
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Mansfield
Cleveland Clinic Cancer Center Mansfield
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Mayfield Heights
Hillcrest Hospital Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
UH Seidman Cancer Center at Landerbrook Health Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Medina
Summa Health Center at Lake Medina
Status: Active
Contact: Site Public Contact
Phone: 330-375-4045
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Parma
University Hospitals Parma Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Ravenna
University Hospitals Portage Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Sandusky
North Coast Cancer Care
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
UH Seidman Cancer Center at Firelands Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Strongsville
Cleveland Clinic Cancer Center Strongsville
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
West Chester
University Pointe
Status: Temporarily closed to accrual
Contact: Site Public Contact
Email: clinicaltrials@ucphysicians.com
Westerville
Saint Ann's Hospital
Status: Active
Contact: Site Public Contact
Phone: 614-234-5433
Email: sheree@columbusccop.org
Westlake
UHHS-Westlake Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-641-2422
Email: CTUReferral@UHhospitals.org
Wooster
Cleveland Clinic Wooster Family Health and Surgery Center
Status: Active
Contact: Site Public Contact
Phone: 866-223-8100
Email: CancerAnswer@ccf.org
Zanesville
Genesis Healthcare System Cancer Care Center
Status: Active
Contact: Site Public Contact
Phone: 740-454-5232
Email: sheree@columbusccop.org

Oklahoma

Lawton
Cancer Centers of Southwest Oklahoma Research
Status: Active
Contact: Site Public Contact
Phone: 877-231-4440
Oklahoma City
Mercy Hospital Oklahoma City
Status: Active
Contact: Site Public Contact
Phone: 405-752-3402
University of Oklahoma Health Sciences Center
Status: Active
Contact: Site Public Contact
Phone: 405-271-8777
Email: ou-clinical-trials@ouhsc.edu

Oregon

Corvallis
Good Samaritan Hospital
Status: Active
Contact: Site Public Contact
Phone: 541-768-4352
Email: stmock@samhealth.org
Eugene
Willamette Valley Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 541-681-4930
Email: wade.carson@usoncology.com
Gresham
Legacy Mount Hood Medical Center
Status: Active
Contact: Site Public Contact
Phone: 503-413-2150
Portland
Compass Oncology Rose Quarter
Status: Active
Contact: Site Public Contact
Phone: 503-280-1223
Kaiser Permanente Northwest
Status: Active
Contact: Site Public Contact
Phone: 503-335-2400
Email: information@kpchr.org
The Dalles
Mid-Columbia Medical Center / Celilo Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 541-296-7585

Pennsylvania

Allentown
Lehigh Valley Hospital-Cedar Crest
Status: Active
Contact: Site Public Contact
Phone: 734-712-3671
Email: stephanie.couch@stjoeshealth.org
Beaver
UPMC-Heritage Valley Health System Beaver
Status: Active
Contact: Site Public Contact
Phone: 724-773-7616
Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Status: Active
Contact: Site Public Contact
Phone: 484-503-4151
Broomall
Crozer-Keystone Regional Cancer Center at Broomall
Status: Active
Contact: Site Public Contact
Phone: 610-284-8237
Email: Jolene.garney@crozer.org
Bryn Mawr
Bryn Mawr Hospital
Status: Active
Contact: Site Public Contact
Phone: 484-476-2649
Email: turzoe@mlhs.org
Chadds Ford
Christiana Care Health System-Concord Health Center
Status: Active
Contact: Site Public Contact
Phone: 302-623-4450
Email: KDempsey@christianacare.org
Dunmore
Northeast Radiation Oncology Center
Status: Active
Contact: Site Public Contact
Phone: 888-808-6762
Ephrata
Ephrata Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 717-721-4840
Erie
Saint Vincent Hospital
Status: Active
Contact: Site Public Contact
Phone: 814-452-5000
The Regional Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 814-838-0448
Email: mhaynes@trcc.org
Furlong
Fox Chase Cancer Center Buckingham
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 215-794-2700
Gettysburg
Adams Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-441-7957
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Status: Active
Contact: Site Public Contact
Phone: 724-838-1900
Harrisburg
UPMC Pinnacle Cancer Center / Community Osteopathic Campus
Status: Active
Contact: Site Public Contact
Phone: 717-724-6765
Email: klitchfield@PINNACLEHEALTH.org
Jefferson Hills
Jefferson Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-359-3043
Email: ddefazio@wpahs.org
Lancaster
Lancaster General Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 717-544-5511
Meadowbrook
Holy Redeemer Hospital and Medical Center
Status: Active
Contact: Site Public Contact
Phone: 215-938-3551
Monroeville
Forbes Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-858-7746
Intercommunity Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 412-856-7740
Moon Township
UPMC-Coraopolis / Heritage Valley Radiation Oncology
Status: Active
Contact: Site Public Contact
Phone: 412-604-2020
Natrona Heights
Allegheny Valley Hospital
Status: Active
Contact: Site Public Contact
Phone: 724-226-7380
Philadelphia
Aria Health-Torresdale Campus
Status: Active
Contact: Site Public Contact
Phone: 215-612-5296
Fox Chase Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 215-728-4790
Pennsylvania Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-789-7366
Temple University Hospital
Status: Active
Contact: Site Public Contact
Phone: 215-728-2983
Thomas Jefferson University Hospital
Status: Active
Contact: Site Public Contact
Phone: 215-955-6084
University of Pennsylvania / Abramson Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-474-9892
Pittsburgh
Allegheny General Hospital
Status: Active
Contact: Site Public Contact
Phone: 877-284-2000
UPMC-Magee Womens Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-647-2811
UPMC-Shadyside Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-621-2334
West Penn Hospital
Status: Active
Contact: Site Public Contact
Phone: 412-578-5000
Sayre
Guthrie Medical Group PC-Robert Packer Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-836-0388
Washington
UPMC Washington Hospital Radiation Oncology
Status: Active
Contact: Site Public Contact
Phone: 724-223-3788
Email: cancer@washingtonhospital.org
West Chester
Chester County Hospital
Status: Active
Contact: Site Public Contact
Phone: 610-431-5297
West Reading
Reading Hospital
Status: Active
Contact: Site Public Contact
Phone: 610-988-9323
Wexford
Wexford Health and Wellness Pavilion
Status: Active
Contact: Site Public Contact
Phone: 412-359-3043
Email: ddefazio@wpahs.org
Wynnewood
Lankenau Medical Center
Status: Active
Contact: Site Public Contact
Phone: 484-476-2649
Email: turzoe@mlhs.org
York
WellSpan Health-York Hospital
Status: Active
Contact: Site Public Contact
Phone: 877-441-7957

Puerto Rico

San Juan
San Juan City Hospital
Status: Active
Contact: Site Public Contact
Phone: 787-763-1296

Rhode Island

Providence
Radiation Oncology Associates Incorporated
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 401-521-9700
Rhode Island Hospital
Status: Active
Contact: Site Public Contact
Phone: 401-444-1488
Women and Infants Hospital
Status: Active
Contact: Site Public Contact
Phone: 401-274-1122
Warwick
Kent Hospital
Status: Active
Contact: Site Public Contact
Phone: 401-737-7010

South Carolina

Charleston
Bon Secours Saint Francis Hospital
Status: Active
Contact: Site Public Contact
Phone: 843-724-2348
Email: Courtney.Roldan@RoperSaintFrancis.com
Medical University of South Carolina
Status: Active
Contact: Site Public Contact
Phone: 843-792-9321
Email: hcc-clinical-trials@musc.edu
Roper Hospital
Status: Active
Contact: Site Public Contact
Phone: 843-724-2348
Email: Courtney.Roldan@RoperSaintFrancis.com
Georgetown
Tidelands Georgetown Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 843-545-5600
Email: broe@tidelandshealth.org
Greenville
Greenville Health System Cancer Institute-Andrews
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Greenville Health System Cancer Institute-Eastside
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Greenville Health System Cancer Institute-Faris
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Saint Francis Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 864-603-6213
Email: meissa_beckman@bshsi.org
Greenwood
Self Regional Healthcare
Status: Active
Contact: Site Public Contact
Phone: 864-725-4771
Email: nmcgaha@selfregional.org
Greer
Gibbs Cancer Center-Pelham
Status: Active
Contact: Site Public Contact
Phone: 864-560-6104
Email: kmertz-rivera@gibbscc.org
Greenville Health System Cancer Institute-Greer
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Hilton Head Island
The Radiation Oncology Center-Hilton Head / Bluffton
Status: Active
Contact: Site Public Contact
Phone: 912-819-5704
Email: underberga@sjchs.org
Seneca
Greenville Health System Cancer Institute-Seneca
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Spartanburg
Greenville Health System Cancer Institute-Spartanburg
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 864-241-6251
Email: kwilliams8@ghs.org
Spartanburg Medical Center
Status: Active
Contact: Site Public Contact
Phone: 864-560-6104
Email: kmertz-rivera@gibbscc.org
West Columbia
Lexington Medical Center
Status: Active
Contact: Site Public Contact
Phone: 803-936-8050

Tennessee

Germantown
The West Clinic - Wolf River
Status: Active
Contact: Site Public Contact
Phone: 901-683-0055
Email: afletcher@westclinic.com
Knoxville
Thompson Cancer Survival Center
Status: Active
Contact: Site Public Contact
Phone: 865-331-1812
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Status: Active
Contact: Site Public Contact
Phone: 901-226-1366
Email: BCCclintrials@bmhcc.org
Nashville
Vanderbilt University / Ingram Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 800-811-8480

Texas

Abilene
Texas Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Amarillo
The Don and Sybil Harrington Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 806-212-1985
Email: gcravey@harringtoncc.org
Arlington
Texas Oncology-Arlington South
Status: Active
Contact: Site Public Contact
Phone: 817-467-6092
Austin
Texas Oncology - Central Austin Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 512-427-9400
Texas Oncology - South Austin Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 512-447-2202
Texas Oncology-Austin Midtown
Status: Active
Contact: Site Public Contact
Phone: 512-421-4163
Beaumont
Texas Oncology PA Beaumont
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Bedford
Texas Oncology Bedford
Status: Active
Contact: Site Public Contact
Phone: 817-359-9000
Dallas
Parkland Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 214-590-5582
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern / Simmons Cancer Center-Dallas
Status: Active
Contact: Site Public Contact
Phone: 214-648-7097
Email: canceranswerline@UTSouthwestern.edu
Denton
Texas Oncology-Denton South
Status: Active
Contact: Site Public Contact
Phone: 940-382-1022
Flower Mound
Texas Oncology-Flower Mound
Status: Active
Contact: Site Public Contact
Phone: 972-537-4100
Fort Worth
Texas Oncology - Fort Worth Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 817-820-4700
Email: Nori.sullivan@usoncology.com
Galveston
University of Texas Medical Branch
Status: Active
Contact: Site Public Contact
Phone: 409-772-1950
Email: clinical.research@utmb.edu
Houston
M D Anderson Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-632-6789
Email: askmdanderson@mdanderson.org
MD Anderson in Katy
Status: Active
Contact: Site Public Contact
Phone: 877-632-6789
Email: askmdanderson@mdanderson.org
Memorial Hermann Memorial City Medical Center
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
The Methodist Hospital System
Status: Active
Contact: Site Public Contact
Phone: 713-790-2700
Irving
Baylor Medical Center at Irving
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com
Laredo
Doctor's Hospital of Laredo
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 956-523-2650
Lubbock
Covenant Medical Center-Lakeside
Status: Active
Contact: Site Public Contact
Phone: 806-725-8000
Email: jaccresearch@covhs.org
Texas Tech University Health Sciences Center-Lubbock
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 806-775-8590
University Medical Center
Status: Active
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com
McKinney
Texas Oncology-McKinney
Status: Active
Contact: Site Public Contact
Phone: 972-542-8609
Nassau Bay
MD Anderson League City
Status: Active
Contact: Site Public Contact
Phone: 877-632-6789
Email: askmdanderson@mdanderson.org
Plano
Texas Oncology-Plano West
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Round Rock
Scott and White Healthcare Round Rock
Status: Active
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com
Texas Oncology - Round Rock Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 512-341-8724
San Antonio
University of Texas Health Science Center at San Antonio
Status: Active
Contact: Site Public Contact
Phone: 210-450-3800
Email: phoresearchoffice@uthscsa.edu
Sherman
Texas Cancer Center-Sherman
Status: Active
Contact: Site Public Contact
Phone: 903-868-4700
Sugar Land
Houston Methodist Sugar Land Hospital
Status: Active
Contact: Site Public Contact
Phone: 281-242-2873
MD Anderson in Sugar Land
Status: Active
Contact: Site Public Contact
Phone: 877-632-6789
Email: askmdanderson@mdanderson.org
Texas Oncology Cancer Center Sugar Land
Status: Active
Contact: Site Public Contact
Phone: 281-277-5200
Temple
Scott and White Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 254-724-5407
The Woodlands
MD Anderson in The Woodlands
Status: Active
Contact: Site Public Contact
Phone: 866-632-6789
Email: askmdanderson@mdanderson.org
Webster
Deke Slayton Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org

Utah

Farmington
Farmington Health Center
Status: Active
Contact: Site Public Contact
Phone: 888-424-2100
Email: cancerinfo@hci.utah.edu
Murray
Intermountain Medical Center
Status: Active
Contact: Site Public Contact
Phone: 801-507-3950
Email: officeofresearch@imail.org
Ogden
McKay-Dee Hospital Center
Status: Active
Contact: Site Public Contact
Phone: 801-387-7426
Email: officeofresearch@imail.org
Provo
Utah Valley Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 801-357-7965
Email: officeofresearch@imail.org
Salt Lake City
Huntsman Cancer Institute / University of Utah
Status: Active
Contact: Site Public Contact
Phone: 888-424-2100
Email: cancerinfo@hci.utah.edu
South Jordan
South Jordan Health Center
Status: Active
Contact: Site Public Contact
Phone: 888-424-2100
Email: cancerinfo@hci.utah.edu

Vermont

Saint Johnsbury
Norris Cotton Cancer Center-North
Status: Active
Contact: Site Public Contact
Phone: 802-473-4100

Virginia

Alexandria
Inova Alexandria Hospital
Status: Active
Contact: Site Public Contact
Phone: 703-776-2580
Email: Stephanie.VanBebber@inova.org
Charlottesville
University of Virginia Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 434-243-6303
Email: PAS9E@virginia.edu
Falls Church
Inova Fairfax Hospital
Status: Active
Contact: Site Public Contact
Phone: 703-208-6650
Email: Stephanie.VanBebber@inova.org
Fishersville
Augusta Health Center for Cancer and Blood Disorders
Status: Active
Contact: Site Public Contact
Phone: 540-332-5960
Hampton
Sentara Cancer Institute at Sentara CarePlex Hospital
Status: Active
Contact: Site Public Contact
Phone: 757-388-2840
Email: cancerresearch@sentara.com
Norfolk
Sentara Norfolk General Hospital
Status: Active
Contact: Site Public Contact
Phone: 757-388-2406
Portsmouth
Naval Medical Center - Portsmouth
Status: Active
Contact: Site Public Contact
Phone: 757-953-5939
Richmond
Virginia Commonwealth University / Massey Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 804-628-1939
Email: mwellons@vcu.edu
Roanoke
Oncology and Hematology Associates of Southwest Virginia
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Suffolk
Sentara Obici Hospital
Status: Active
Contact: Site Public Contact
Phone: 757-388-5109
Email: djoverto@sentara.com
Virginia Beach
Sentara Virginia Beach General Hospital
Status: Active
Contact: Site Public Contact
Phone: 757-388-2840
Email: cancerresearch@sentara.com

Washington

Auburn
MultiCare Auburn Medical Center
Status: Active
Contact: Site Public Contact
Phone: 253-887-9333
Email: research@multicare.org
Bellevue
Overlake Hospital Medical Center
Status: Active
Contact: Site Public Contact
Phone: 425-688-5407
Email: OHMCResearch@overlakehospital.org
Bremerton
Harrison Medical Center
Status: Active
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Federal Way
Virginia Mason Federal Way Medical Center
Status: Active
Contact: Site Public Contact
Phone: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Gig Harbor
MultiCare Gig Harbor Medical Park
Status: Active
Contact: Site Public Contact
Phone: 253-403-2394
Email: research@multicare.org
Tacoma / Valley Radiation Oncology Centers-Gig Harbor
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 253-851-5155
Email: info@tacomaradiation.com
Lacey
Providence Regional Cancer System-Lacey
Status: Active
Contact: Site Public Contact
Phone: 360-412-8958
Email: deidre.dillon@providence.org
Mount Vernon
Skagit Valley Hospital Regional Cancer Care Center
Status: Active
Contact: Site Public Contact
Phone: 360-814-2146
Email: rcccclinicalresearch@skagitvalleyhospital.org
Puyallup
MultiCare Good Samaritan Hospital
Status: Active
Contact: Site Public Contact
Phone: 800-351-7955
Email: research@multicare.org
Tacoma / Valley Radiation Oncology Centers-Puyallup
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 253-841-4311
Email: info@tacomaradiation.com
Seattle
Fred Hutchinson Cancer Research Center
Status: Active
Contact: Site Public Contact
Phone: 800-804-8824
Seattle Cancer Care Alliance
Status: Active
Contact: Site Public Contact
Phone: 800-804-8824
Seattle Cancer Care Alliance at Northwest Hospital
Status: Active
Contact: Site Public Contact
Phone: 206-606-5800
University of Washington Medical Center
Status: Active
Contact: Site Public Contact
Phone: 800-804-8824
Virginia Mason Medical Center
Status: Active
Contact: Site Public Contact
Phone: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Spokane
Cancer Care Northwest - Spokane South
Status: Active
Contact: Site Public Contact
Phone: 509-228-1680
Email: research@ccnw.net
Cancer Care Northwest-North Spokane
Status: Active
Contact: Site Public Contact
Phone: 509-228-1680
Email: research@ccnw.net
Spokane Valley Cancer Center-Mayfair
Status: Active
Contact: Site Public Contact
Phone: 412-339-5294
Email: Roster@nrgoncology.org
Tacoma
MultiCare Tacoma General Hospital
Status: Active
Contact: Site Public Contact
Phone: 253-403-3229
Email: research@multicare.org
Northwest Medical Specialties PLLC
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 308-398-6518
Email: clinicaltrials@sfmc-gi.org
Saint Joseph Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 253-426-6914
Tacoma / Valley Radiation Oncology Centers-Saint Joe's
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 253-272-1077
Email: info@tacomaradiation.com
Vancouver
Compass Oncology Vancouver
Status: Active
Contact: Site Public Contact
Phone: 360-449-6521
Email: susan.papenfuse@usoncology.com

West Virginia

Huntington
Edwards Comprehensive Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 304-399-6617
Morgantown
West Virginia University Healthcare
Status: Active
Contact: Site Public Contact
Phone: 304-293-7374
Email: cancertrialsinfo@hsc.wvu.edu

Wisconsin

Antigo
Langlade Hospital and Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 715-623-9869
Email: Juli.Alford@aspirus.org
Appleton
Radiology Associates of Appleton / ThedaCare Regional Medical Center
Status: Active
Contact: Site Public Contact
Phone: 920-380-1500
ThedaCare Regional Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 920-364-3605
Email: Noreen.Wynn@thedacare.org
Brookfield
Wheaton Franciscan Healthcare-Elmbrook Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 262-687-5010
Email: Michelle.czechowicz@ascension.org
Eau Claire
HSHS Sacred Heart Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 715-717-3956
Marshfield Medical Center-EC Cancer Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Franklin
Wheaton Franciscan Healthcare-Saint Francis / Reiman Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 262-687-5010
Email: Michelle.czechowicz@ascension.org
Grafton
Aurora Cancer Care-Grafton
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Green Bay
Aurora BayCare Medical Center
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Saint Vincent Hospital Cancer Center at Saint Mary's
Status: Active
Contact: Site Public Contact
Phone: 920-433-8889
Email: Christy.Gilchrist@hshs.org
Saint Vincent Hospital Cancer Center Green Bay
Status: Active
Contact: Site Public Contact
Phone: 920-433-8889
Email: Christy.Gilchrist@hshs.org
Johnson Creek
UW Cancer Center Johnson Creek
Status: Active
Contact: Site Public Contact
Phone: 920-699-3500
Email: lynda.persico@uwmf.wisc.edu
Kenosha
Aurora Cancer Care-Kenosha South
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
La Crosse
Gundersen Lutheran Medical Center
Status: Active
Contact: Site Public Contact
Phone: 608-775-2385
Email: cancerctr@gundersenhealth.org
Mayo Clinic Health System-Franciscan Healthcare
Status: Active
Contact: Site Public Contact
Phone: 855-776-0015
Madison
University of Wisconsin Hospital and Clinics
Status: Active
Contact: Site Public Contact
Phone: 800-622-8922
Marshfield
Marshfield Medical Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center-Marshfield
Status: Active
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Menomonee Falls
Community Memorial Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 262-257-5100
Milwaukee
Aurora Saint Luke's Medical Center
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Aurora Sinai Medical Center
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Froedtert and the Medical College of Wisconsin
Status: Active
Contact: Site Public Contact
Phone: 414-805-4380
Minocqua
Marshfield Clinic-Minocqua Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Mukwonago
ProHealth D N Greenwald Center
Status: Active
Contact: Site Public Contact
Email: research.institute@phci.org
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Status: Active
Contact: Site Public Contact
Phone: 262-928-7878
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Racine
Wheaton Franciscan Cancer Care - All Saints
Status: Active
Contact: Site Public Contact
Phone: 262-687-5010
Email: Michelle.czechowicz@ascension.org
Rice Lake
Marshfield Medical Center-Rice Lake
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Stevens Point
Marshfield Clinic Stevens Point Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 800-782-8581
Email: oncology.clinical.trials@marshfieldresearch.org
Saint Michael's Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 888-823-5923
Email: ctsucontact@westat.com
Summit
Aurora Medical Center in Summit
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
Waukesha
ProHealth Waukesha Memorial Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 262-928-7632
UW Cancer Center at ProHealth Care
Status: Active
Contact: Site Public Contact
Phone: 262-928-5539
Email: Chanda.miller@phci.org
Wausau
Aspirus Regional Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 877-405-6866
Wauwatosa
Aurora Cancer Care-Milwaukee West
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
West Allis
Aurora West Allis Medical Center
Status: Active
Contact: Site Public Contact
Phone: 414-302-2304
Email: ncorp@aurora.org
West Bend
The Alyce and Elmore Kraemer Cancer Care Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 866-680-0505
Weston
Diagnostic and Treatment Center
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 888-799-3989
Email: oncology.clinical.trials@marshfieldresearch.org

Alberta

Calgary
Tom Baker Cancer Centre
Status: Active
Contact: Site Public Contact
Phone: 403-521-3433
Edmonton
Cross Cancer Institute
Status: Active
Contact: Site Public Contact
Phone: 780-432-8500

Manitoba

Winnipeg
CancerCare Manitoba
Status: Active
Contact: Site Public Contact
Phone: 866-561-1026
Email: ctu_web@cancercare.mb.ca

New Brunswick

Saint John
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 506-648-6890

Ontario

London
London Regional Cancer Program
Status: Active
Contact: Site Public Contact
Phone: 519-685-8600
Toronto
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Status: Active
Contact: Site Public Contact
Phone: 416-480-5000

Quebec

Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal
Status: Active
Contact: Site Public Contact
Phone: 514-890-8000ext12725
Email: info.cr.chum@ssss.gouv.qc.ca
CHUM - Hopital Notre-Dame
Status: Active
Contact: Valerie Theberge
Phone: 418-649-5593
Email: jbegin@uresp.ulaval.ca
CHUM-Hotel Dieu de Montreal
Status: Active
Contact: Valerie Theberge
Phone: 418-649-5593
Email: jbegin@uresp.ulaval.ca
CIUSSSEMTL-Hopital Maisonneuve-Rosemont
Status: Temporarily closed to accrual
Contact: Site Public Contact
Phone: 514-252-3400ext3329
Jewish General Hospital
Status: Active
Contact: Site Public Contact
Phone: 514-340-8222ext8248
McGill University Department of Oncology
Status: Active
Contact: Christine Lambert
Phone: 514-934-4400
The Research Institute of the McGill University Health Centre (MUHC)
Status: Active
Contact: Site Public Contact
Phone: 514-934-1934ext48354
Email: evelyn.ortega@muhc.mcgill.ca
Quebec City
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Status: Active
Contact: Site Public Contact
Email: rechclinique@crchuq.ulaval.ca
Sherbrooke
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Status: Active
Contact: Site Public Contact
Phone: 819-820-6480
Email: crcinformation.chus@ssss.gouv.qc.ca

Saskatchewan

Regina
Allan Blair Cancer Centre
Status: Active
Contact: Site Public Contact
Phone: 306-766-2213
Saskatoon
Saskatoon Cancer Centre
Status: Active
Contact: Site Public Contact
Phone: 306-655-2914

Australia

East Bentleigh
Monash Medical Centre Moorabbin Campus
Status: Active
Contact: Site Public Contact
Phone: 61 3 9928 8951
Email: kate.crough@petermac.org
Melbourne
Peter MacCallum Cancer Centre
Status: Active
Contact: Site Public Contact
Phone: 61 3 9656 1521

Ireland

Dublin
Saint Lukes Hospital
Status: Active
Contact: Site Public Contact
Phone: 353 1 4065000
Galway
University College Hospital Galway
Status: Active
Contact: Site Public Contact
Phone: 353 1 8287100
Email: info@cancercontrol.ie

Israel

Tel Hashomer
Chaim Sheba Medical Center
Status: Active
Contact: Site Public Contact
Phone: 972 3 530-5943

Japan

Akashi-city
Hyogo Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 81 78-929-1151
Gunma
Gunma University Hospital
Status: Active
Contact: Site Public Contact
Phone: 81-27-220-7626
Matsuyama
Shikoku Cancer Center
Status: Active
Contact: Site Public Contact
Phone: 089-999-1172
Morioka
Iwate Medical University School of Medicine
Status: Active
Contact: Site Public Contact
Phone: 019-651-5111
Niigata City
Niigata University Medical and Dental Hospital
Status: Active
Contact: Site Public Contact
Phone: 81-025-223-6161
Saitama
Saitama Medical University International Medical Center
Status: Active
Contact: Site Public Contact
Phone: 81-49-276-2028
Sapporo
Hokkaido University Hospital
Status: Active
Contact: Site Public Contact
Email: hassi@med.hokudai.ac.jp
Sendai
Tohoku University School of Medicine
Status: Active
Contact: Site Public Contact
Email: med-som@bureau.tohoku.ac.jp
Tokyo
National Cancer Center Hospital
Status: Active
Contact: Site Public Contact
Phone: 81-3-3542-2511
Email: www-admin@ncc.go.jp

Korea, Republic of

Seoul
Yonsei University Health System-Severance Hospital
Status: Active
Contact: Site Public Contact
Email: ihcc@yuhs.ac

Trial Objectives and Outline

PRIMARY OBJECTIVES:

I. To evaluate whether the addition of chest wall + regional nodal radiation therapy (XRT) after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for invasive breast cancer recurrence-free interval (IBC-RFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

SECONDARY OBJECTIVES:

I. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly prolong overall survival (OS) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

II. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rates of events for local-regional recurrence-free interval (LRRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

III. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for distant recurrence-free interval (DRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

IV. To compare the rates of disease-free survival (DFS)-ductal carcinoma in situ (DCIS) by treatment arm.

V. To compare the rates of second primary cancer by treatment arm.

VI. To compare the effect of adding XRT on the cosmetic outcomes in mastectomy patients who have had reconstruction.

VII. To compare the effect of adding XRT on quality of life including arm problems, lymphedema, pain, and fatigue.

VIII. To evaluate the toxicity associated with each of the radiation therapy regimens.

IX. To determine whether computed tomography (CT)-based conformal methods (intensity-modulated radiation therapy [IMRT] and 3-dimensional conformal radiation therapy [3DCRT]) for chest-wall + regional nodal XRT post mastectomy and regional nodal XRT with breast XRT following breast conserving surgery are feasible in a multi-institutional setting and whether dose-volume analyses can be established to assess treatment adequacy and to develop normal tissue complication probabilities (NTCP) for the likelihood of toxicity.

X. To compare the effect of XRT in patients receiving mastectomy and in patients receiving lumpectomy.

XI. To examine the role of proliferation measures as a prognosticator for patients with residual disease after neoadjuvant chemotherapy.

XII. To develop predictors of the degree of reduction in local regional recurrence (LRR).

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients are assigned to 1 of 2 treatment groups.

GROUP IA: Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3D-CRT once daily (QD) 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.

GROUP IB: Mastectomy patients do not undergo radiation therapy.

ARM II: Patients are assigned to 1 of 2 treatment groups.

GROUP IIA: Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3D-CRT QD 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity QD 5 days a week for 1-1/2 weeks.

GROUP IIB: Mastectomy patients undergo regional nodal radiation therapy using IMRT or 3D-CRT QD 5 days a week for 5 weeks.

All patients also receive systemic therapy as planned (hormonal therapy for patients with hormone-receptor positive breast cancer and trastuzumab or other anti-human epidermal growth factor receptor 2 [HER2] therapy for patients with breast cancer that is HER2-positive).

After completion of study treatment, patients are followed up at 6, 12, 18, and 24 months and then yearly for 8 years.

Trial Phase & Type

Trial Phase

Phase III

Trial Type

Treatment

Lead Organization

Lead Organization
NRG Oncology

Principal Investigator
Eleftherios (Terry) Paul Mamounas

Trial IDs

Primary ID NSABP-B-51
Secondary IDs NCI-2012-03198, NSABP-B-51/RTOG-1304
Clinicaltrials.gov ID NCT01872975